IL134533A0 - Improvements in or relating to the preparation of lactam compounds - Google Patents
Improvements in or relating to the preparation of lactam compoundsInfo
- Publication number
- IL134533A0 IL134533A0 IL13453398A IL13453398A IL134533A0 IL 134533 A0 IL134533 A0 IL 134533A0 IL 13453398 A IL13453398 A IL 13453398A IL 13453398 A IL13453398 A IL 13453398A IL 134533 A0 IL134533 A0 IL 134533A0
- Authority
- IL
- Israel
- Prior art keywords
- compound
- solvent
- apa
- tetrafluoroethane
- isolated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Cephalosporin Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic acid (6-APA), may be prepared by enzymatic conversion of a first compound, for example penicillin-G, in a solvent mixture comprising water and a non-aqueous organic solvent, for example 1,1,1, 2-tetrafluoroethane. The 6-APA can be caused to precipitate, isolated by filtration and optionally derivatized to produce a desired compound. A by-product of the enzymatic conversion, for example phenylacetic acid, can be isolated by solvent extraction, suitably using a solvent which also comprises 1, 1, 1, 2-tetrafluoroethane.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9718740.5A GB9718740D0 (en) | 1997-09-05 | 1997-09-05 | Improvements in or relating to the preparation of a compound |
| PCT/GB1998/002645 WO1999013098A1 (en) | 1997-09-05 | 1998-09-03 | Improvements in or relating to the preparation of lactam compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL134533A0 true IL134533A0 (en) | 2001-04-30 |
Family
ID=10818508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13453398A IL134533A0 (en) | 1997-09-05 | 1998-09-03 | Improvements in or relating to the preparation of lactam compounds |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6383772B1 (en) |
| EP (1) | EP1009849B1 (en) |
| JP (1) | JP2001515729A (en) |
| CN (1) | CN1269838A (en) |
| AT (1) | ATE269906T1 (en) |
| AU (1) | AU751593B2 (en) |
| CA (1) | CA2302443A1 (en) |
| DE (1) | DE69824744T2 (en) |
| ES (1) | ES2224424T3 (en) |
| GB (2) | GB9718740D0 (en) |
| IL (1) | IL134533A0 (en) |
| IN (1) | IN191608B (en) |
| NZ (1) | NZ503159A (en) |
| PL (1) | PL338986A1 (en) |
| WO (1) | WO1999013098A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075801C (en) * | 1999-01-18 | 2001-12-05 | 郝常明 | Process for extracting phenylacetic acid from waste liquid of cracking production of 6-amino-penicillanic acid |
| MXPA03001712A (en) * | 2000-08-28 | 2004-09-10 | Dsm Nv | PROCESS FOR THE PREPARATION OF A bgr;-LACTAM NUCLEUS AND THE APPLICATION THEREOF. |
| US6589422B2 (en) | 2000-12-18 | 2003-07-08 | Ineos Fluor Holdings Limited | Apparatus and method for extracting biomass |
| GB0306267D0 (en) * | 2003-03-19 | 2003-04-23 | Ineos Fluor Ltd | Process |
| WO2006036473A1 (en) * | 2004-09-24 | 2006-04-06 | 3M Innovative Properties Company | Medicinal aerosol formulations and methods of synthesizing ingredients therefor |
| WO2008054609A2 (en) * | 2006-10-04 | 2008-05-08 | The Regents Of The University Of Michigan | Dissolution and precipitation of cocrystals with ionizable components |
| CN101157945B (en) * | 2007-09-13 | 2010-06-02 | 中国海洋大学 | Technique for preparing glycerin ester rich in polyunsaturated fatty acid |
| CN103408419B (en) * | 2013-08-19 | 2014-10-15 | 江苏九九久科技股份有限公司 | Method for treating 7-ADCA (Amino Desacetoxy Cephalosporanic Acid) extract liquor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3530148A (en) | 1967-10-30 | 1970-09-22 | Mitsui Toatsu Chemicals | Process for producing tetraoxane |
| BE727506A (en) | 1968-02-15 | 1969-07-01 | ||
| JPS57501610A (en) * | 1980-10-23 | 1982-09-09 | ||
| NL8301373A (en) | 1983-04-19 | 1984-11-16 | Tno | IMMOBILIZED BIO CATALYSTS. |
| JPS6066981A (en) | 1983-09-12 | 1985-04-17 | アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン | Insoluble penicillin amydase and its production |
| FR2588272B1 (en) * | 1985-10-07 | 1988-12-02 | Gattefosse Ets Sa | PROCESS FOR THE SYNTHESIS OF ORGANIC ACID ESTERS AND ALCOHOLS IN THE HETEROGENEOUS PHASE BY ENZYMATIC CATALYSIS |
| NL8603105A (en) * | 1986-12-05 | 1988-07-01 | Rijkslandbouwhogeschool | METHOD FOR PERFORMING BIOTECHNOLOGICAL PROCESSES USING A MULTI-PHASE SYSTEM IN A LOOP REACTOR |
| IT1252308B (en) | 1990-12-21 | 1995-06-08 | Antibioticos Spa | ENZYMATIC PROCEDURE FOR THE PRODUCTION OF 7- AMINOCEPHALOSPORANIC ACID AND DERIVATIVES |
| US5500352A (en) | 1993-03-24 | 1996-03-19 | Sepracor, Inc. | Membrane filtration process for 6-aminopenicillanic acid |
| ES2105989B1 (en) | 1996-03-15 | 1998-07-01 | Antibioticos Sa | ALTERNATIVE PROCEDURE FOR THE OBTAINING OF 6-AMINO PENICILANIC ACID (6-APA). |
-
1997
- 1997-09-05 GB GBGB9718740.5A patent/GB9718740D0/en not_active Ceased
-
1998
- 1998-09-02 IN IN2610DE1998 patent/IN191608B/en unknown
- 1998-09-03 JP JP2000510883A patent/JP2001515729A/en active Pending
- 1998-09-03 EP EP98940467A patent/EP1009849B1/en not_active Expired - Lifetime
- 1998-09-03 IL IL13453398A patent/IL134533A0/en unknown
- 1998-09-03 AT AT98940467T patent/ATE269906T1/en not_active IP Right Cessation
- 1998-09-03 DE DE69824744T patent/DE69824744T2/en not_active Expired - Fee Related
- 1998-09-03 GB GB9819267A patent/GB2328943B/en not_active Revoked
- 1998-09-03 US US09/486,691 patent/US6383772B1/en not_active Expired - Fee Related
- 1998-09-03 WO PCT/GB1998/002645 patent/WO1999013098A1/en not_active Application Discontinuation
- 1998-09-03 ES ES98940467T patent/ES2224424T3/en not_active Expired - Lifetime
- 1998-09-03 AU AU88788/98A patent/AU751593B2/en not_active Ceased
- 1998-09-03 PL PL98338986A patent/PL338986A1/en unknown
- 1998-09-03 CN CN98808882A patent/CN1269838A/en active Pending
- 1998-09-03 NZ NZ503159A patent/NZ503159A/en unknown
- 1998-09-03 CA CA002302443A patent/CA2302443A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999013098A1 (en) | 1999-03-18 |
| CN1269838A (en) | 2000-10-11 |
| JP2001515729A (en) | 2001-09-25 |
| GB2328943A (en) | 1999-03-10 |
| ATE269906T1 (en) | 2004-07-15 |
| US6383772B1 (en) | 2002-05-07 |
| GB9819267D0 (en) | 1998-10-28 |
| ES2224424T3 (en) | 2005-03-01 |
| AU8878898A (en) | 1999-03-29 |
| GB9718740D0 (en) | 1997-11-12 |
| GB2328943B (en) | 2002-05-22 |
| AU751593B2 (en) | 2002-08-22 |
| IN191608B (en) | 2003-12-06 |
| EP1009849A1 (en) | 2000-06-21 |
| NZ503159A (en) | 2002-07-26 |
| CA2302443A1 (en) | 1999-03-18 |
| PL338986A1 (en) | 2000-12-04 |
| EP1009849B1 (en) | 2004-06-23 |
| DE69824744D1 (en) | 2004-07-29 |
| DE69824744T2 (en) | 2005-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU7777587A (en) | Optically active compounds | |
| IL134533A0 (en) | Improvements in or relating to the preparation of lactam compounds | |
| AU4152897A (en) | Polymeric thickeners for aqueous compositions | |
| KR960702468A (en) | Enantioselective oxazaborolidine catalysts | |
| IL78462A0 (en) | Process for racemizing an optically active n-benzylidene amino-acid amide | |
| PL336385A1 (en) | Improved method of obtaining penicilin by fermentation | |
| ES2001410A6 (en) | Clavam derivatives, preparation and intermediates therefor. | |
| ES8706203A1 (en) | Process for the preparation of arylglycidyl ethers and 3-substituted 1-alkylamino-2-propanols. | |
| IL141284A0 (en) | Process for the production of n-protected azetidine-2-carboxylic acids (azeohs) | |
| WO2001025215A3 (en) | Method for selectively dissociating cyclic carboxylic acid anhydrides | |
| AU7677798A (en) | Process for the preparation of ampicillin | |
| EP1078931A3 (en) | Process for the preparation of vitamin D analogues | |
| WO1999003821A3 (en) | Process for isomerisation of tilidine | |
| AU4958296A (en) | Process for the recovery of ampicillin | |
| AU1935299A (en) | Chloropyrimidine process | |
| MD970270A (en) | Process for obtaining the acid chloride compounds | |
| JO2194B1 (en) | Process for the preparation of vitmain d analogues | |
| AU7581696A (en) | Preparation of chiral 3-hydroxy-2-pyrrolidinone derivatives | |
| UA29641A (en) | Process for preparation of phenothiazine derivative |