IL132786A0 - Hmg-coa reductase inhibitor preparation process - Google Patents

Hmg-coa reductase inhibitor preparation process

Info

Publication number
IL132786A0
IL132786A0 IL13278698A IL13278698A IL132786A0 IL 132786 A0 IL132786 A0 IL 132786A0 IL 13278698 A IL13278698 A IL 13278698A IL 13278698 A IL13278698 A IL 13278698A IL 132786 A0 IL132786 A0 IL 132786A0
Authority
IL
Israel
Prior art keywords
hmg
preparation process
coa reductase
reductase inhibitor
inhibitor preparation
Prior art date
Application number
IL13278698A
Other languages
English (en)
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of IL132786A0 publication Critical patent/IL132786A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13278698A 1997-05-07 1998-05-04 Hmg-coa reductase inhibitor preparation process IL132786A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97303111A EP0877089A1 (de) 1997-05-07 1997-05-07 Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
PCT/EP1998/002616 WO1998050572A1 (en) 1997-05-07 1998-05-04 HMG-CoA REDUCTASE INHIBITOR PREPARATION PROCESS

Publications (1)

Publication Number Publication Date
IL132786A0 true IL132786A0 (en) 2001-03-19

Family

ID=8229319

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13278698A IL132786A0 (en) 1997-05-07 1998-05-04 Hmg-coa reductase inhibitor preparation process

Country Status (7)

Country Link
US (1) US6268186B1 (de)
EP (2) EP0877089A1 (de)
JP (1) JP2002510197A (de)
AU (1) AU7761398A (de)
HU (1) HUP0002103A3 (de)
IL (1) IL132786A0 (de)
WO (1) WO1998050572A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0251582A (ja) * 1988-08-12 1990-02-21 Kyokado Eng Co Ltd 地盤注入用薬液
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
US6372462B2 (en) 1999-10-15 2002-04-16 Medmyco Ltd. Process for producing, methods and compositions of cholesterol lowering agents from higher basidiomycetes mushrooms
IL155194A0 (en) * 2000-10-05 2003-11-23 Biogal Pharmaceutical Co Ltd Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
JP3463881B2 (ja) 2002-08-06 2003-11-05 三共株式会社 プラバスタチン又はその薬理上許容される塩の単離・精製方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
WO2004111255A1 (en) * 2003-06-09 2004-12-23 TEVA Gyógyszergyár Részvénytársaság Ion-exchange filtration of fermentation broth
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
EP1732912B1 (de) 2004-03-30 2008-11-12 Lupin Ltd. Verbessertes verfahren zur herstellung von 4-hydroxypyran-2-onderivaten
US8080560B2 (en) 2004-12-17 2011-12-20 3M Innovative Properties Company Immune response modifier formulations containing oleic acid and methods
US8889154B2 (en) 2005-09-15 2014-11-18 Medicis Pharmaceutical Corporation Packaging for 1-(2-methylpropyl)-1H-imidazo[4,5-c] quinolin-4-amine-containing formulation
WO2008016475A2 (en) 2006-07-31 2008-02-07 3M Innovative Properties Company Immune response modifier compositions and methods
HRP20120184T1 (hr) * 2008-04-02 2012-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Ekstrakcija pravastatina
RU2585234C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Способ получения компактина
RU2585233C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Промышленный способ получения компактина

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294926A (en) * 1979-06-15 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4940727A (en) * 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5989877A (en) * 1995-08-03 1999-11-23 Gist-Brocades B.V. Selective process for the deacylation of acylated compounds
DK0784605T3 (da) * 1995-08-03 2000-07-31 Dsm Nv Selektiv fremgangsmåde til deacyleringen af acylforbindelser

Also Published As

Publication number Publication date
HUP0002103A3 (en) 2001-10-29
AU7761398A (en) 1998-11-27
JP2002510197A (ja) 2002-04-02
EP0980437A1 (de) 2000-02-23
HUP0002103A1 (hu) 2000-10-28
US6268186B1 (en) 2001-07-31
WO1998050572A1 (en) 1998-11-12
EP0877089A1 (de) 1998-11-11

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