IL115591A - Pharmaceutical formulation comprising a growth hormone and valine - Google Patents
Pharmaceutical formulation comprising a growth hormone and valineInfo
- Publication number
- IL115591A IL115591A IL11559195A IL11559195A IL115591A IL 115591 A IL115591 A IL 115591A IL 11559195 A IL11559195 A IL 11559195A IL 11559195 A IL11559195 A IL 11559195A IL 115591 A IL115591 A IL 115591A
- Authority
- IL
- Israel
- Prior art keywords
- valine
- growth hormone
- pharmaceutical formulation
- dissolved
- formulation
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 title abstract 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000004474 valine Substances 0.000 title abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/322,260 US5547696A (en) | 1994-10-13 | 1994-10-13 | Pharmaceutical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL115591A0 IL115591A0 (en) | 1996-01-19 |
| IL115591A true IL115591A (en) | 2000-01-31 |
Family
ID=23254095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11559195A IL115591A (en) | 1994-10-13 | 1995-10-12 | Pharmaceutical formulation comprising a growth hormone and valine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5547696A (de) |
| EP (1) | EP0785795B1 (de) |
| JP (1) | JP4064453B2 (de) |
| KR (1) | KR970706840A (de) |
| AT (1) | ATE211653T1 (de) |
| AU (1) | AU699346B2 (de) |
| DE (1) | DE69524965T2 (de) |
| ES (1) | ES2171555T3 (de) |
| IL (1) | IL115591A (de) |
| PT (1) | PT785795E (de) |
| WO (1) | WO1996011702A1 (de) |
| ZA (1) | ZA958605B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| US6673335B1 (en) | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| ES2179831T3 (es) | 1992-09-29 | 2003-02-01 | Inhale Therapeutic Syst | Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana. |
| NZ281112A (en) | 1994-03-07 | 1998-04-27 | Inhale Therapeutic Syst | Powdered insulin delivered as an aerosol |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| ES2525087T5 (es) | 2000-05-10 | 2018-06-28 | Novartis Ag | Polvos basados en fosfolípidos para administración de fármacos |
| TWI283182B (en) * | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| EP2170268A2 (de) * | 2007-06-25 | 2010-04-07 | Amgen, Inc. | Zusammensetzungen von spezifischen bindungsmitteln für den hepatozyten-wachstumsfaktor |
| CN116421566B (zh) * | 2023-02-16 | 2024-10-22 | 高邮市人民医院 | 一种含聚乙二醇化重组人生长激素的制剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537769A (en) * | 1982-04-06 | 1985-08-27 | American Cyanamid Company | Stabilization of influenza virus vaccine |
| DE3228502A1 (de) * | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
| JPS5967228A (ja) * | 1982-10-07 | 1984-04-16 | Green Cross Corp:The | 寒冷不溶性グロブリンの凍結乾燥方法 |
| SU1232681A1 (ru) * | 1984-11-20 | 1986-05-23 | Научно-Исследовательский Технологический Институт Аминокислот | Штамм @ @ СН-1-продуцент @ -валина |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| US5041378A (en) * | 1987-08-11 | 1991-08-20 | Cetus Corporation | Procaryotic xylose isomerase muteins |
| EP0303746B2 (de) * | 1987-08-21 | 1998-12-02 | Mallinckrodt Group Inc. | Stabilisierung von Wachstumshormonen |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| EP0374120A3 (de) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Zusammensetzung mit kontrollierter Wirkstoffabgabe von Polypeptiden |
| DK0618807T3 (da) * | 1991-12-20 | 2003-03-03 | Novo Nordisk As | Stabiliseret farmaceutisk formulering omfattende human væksthormon og histidin |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| ES2153385T5 (es) * | 1992-07-31 | 2008-09-01 | Genentech, Inc. | Composicion acuosa a base de hormona del crecimiento humana. |
-
1994
- 1994-10-13 US US08/322,260 patent/US5547696A/en not_active Expired - Lifetime
-
1995
- 1995-10-12 IL IL11559195A patent/IL115591A/xx not_active IP Right Cessation
- 1995-10-12 ZA ZA958605A patent/ZA958605B/xx unknown
- 1995-10-13 EP EP95933345A patent/EP0785795B1/de not_active Expired - Lifetime
- 1995-10-13 JP JP51286196A patent/JP4064453B2/ja not_active Expired - Fee Related
- 1995-10-13 DE DE69524965T patent/DE69524965T2/de not_active Expired - Lifetime
- 1995-10-13 AT AT95933345T patent/ATE211653T1/de not_active IP Right Cessation
- 1995-10-13 ES ES95933345T patent/ES2171555T3/es not_active Expired - Lifetime
- 1995-10-13 AU AU36052/95A patent/AU699346B2/en not_active Ceased
- 1995-10-13 PT PT95933345T patent/PT785795E/pt unknown
- 1995-10-13 WO PCT/DK1995/000408 patent/WO1996011702A1/en not_active Ceased
-
1997
- 1997-04-14 KR KR1019970702431A patent/KR970706840A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0785795A1 (de) | 1997-07-30 |
| IL115591A0 (en) | 1996-01-19 |
| DE69524965T2 (de) | 2002-08-14 |
| AU3605295A (en) | 1996-05-06 |
| US5547696A (en) | 1996-08-20 |
| ZA958605B (en) | 1996-05-14 |
| ATE211653T1 (de) | 2002-01-15 |
| PT785795E (pt) | 2002-07-31 |
| JP4064453B2 (ja) | 2008-03-19 |
| WO1996011702A1 (en) | 1996-04-25 |
| ES2171555T3 (es) | 2002-09-16 |
| AU699346B2 (en) | 1998-12-03 |
| KR970706840A (ko) | 1997-12-01 |
| EP0785795B1 (de) | 2002-01-09 |
| JPH10507181A (ja) | 1998-07-14 |
| DE69524965D1 (de) | 2002-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |