IL113757A - Preparation of clavulanic acid - Google Patents
Preparation of clavulanic acidInfo
- Publication number
- IL113757A IL113757A IL113757A IL11375795A IL113757A IL 113757 A IL113757 A IL 113757A IL 113757 A IL113757 A IL 113757A IL 11375795 A IL11375795 A IL 11375795A IL 113757 A IL113757 A IL 113757A
- Authority
- IL
- Israel
- Prior art keywords
- clavulanic acid
- amino
- salt
- alkyl
- ester
- Prior art date
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof which comprises (i) contacting impure clavulanic acid or a salt or ester thereof in an organic solvent, with an amine of the formula R1 NR3 R2 where R1 is a group of the formula R5 N£CH2CH2NH|mCH2CH2 R4 where R4 and R5 are independently hydrogen, alkyl, amino-substituted alkyl or substituted amino-substituted alkyl, and R2 and R3 are independently hydrogen, alkyl, amino- or hydroxy-substituted alkyl or substituted amino-substituted alkyl, and m is zero or an integer 1 to 5; (ii) isolating the amine salt of clavulanic acid formed; (iii) converting the thus formed salt into clavulanic acid or a pharmaceutically acceptable salt or ester thereof. This specification was examined in accordance with regulation 35 of the Patent Regulations, 5728-1968.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929212379A GB9212379D0 (en) | 1992-06-11 | 1992-06-11 | Novel process |
GB929222841A GB9222841D0 (en) | 1992-10-31 | 1992-10-31 | Novel process |
GB929226061A GB9226061D0 (en) | 1992-12-14 | 1992-12-14 | Novel process |
GB929226282A GB9226282D0 (en) | 1992-12-17 | 1992-12-17 | Novel process |
IL105966A IL105966A (en) | 1992-06-11 | 1993-06-09 | Preparation of clavulanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
IL113757A0 IL113757A0 (en) | 1995-08-31 |
IL113757A true IL113757A (en) | 1997-03-18 |
Family
ID=27517131
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL113757A IL113757A (en) | 1992-06-11 | 1993-06-09 | Preparation of clavulanic acid |
IL112751A IL112751A (en) | 1992-06-11 | 1993-06-09 | Preparation and/or purification of clavulanic acid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL112751A IL112751A (en) | 1992-06-11 | 1993-06-09 | Preparation and/or purification of clavulanic acid |
Country Status (1)
Country | Link |
---|---|
IL (2) | IL113757A (en) |
-
1993
- 1993-06-09 IL IL113757A patent/IL113757A/en active IP Right Grant
- 1993-06-09 IL IL112751A patent/IL112751A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL112751A0 (en) | 1995-05-26 |
IL113757A0 (en) | 1995-08-31 |
IL112751A (en) | 1997-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |