IL113757A - Preparation of clavulanic acid - Google Patents

Preparation of clavulanic acid

Info

Publication number
IL113757A
IL113757A IL113757A IL11375795A IL113757A IL 113757 A IL113757 A IL 113757A IL 113757 A IL113757 A IL 113757A IL 11375795 A IL11375795 A IL 11375795A IL 113757 A IL113757 A IL 113757A
Authority
IL
Israel
Prior art keywords
clavulanic acid
amino
salt
alkyl
ester
Prior art date
Application number
IL113757A
Other versions
IL113757A0 (en
Inventor
Michael Allen Cook
Robert Bennett Wilkins
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929212379A external-priority patent/GB9212379D0/en
Priority claimed from GB929222841A external-priority patent/GB9222841D0/en
Priority claimed from GB929226061A external-priority patent/GB9226061D0/en
Priority claimed from GB929226282A external-priority patent/GB9226282D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority claimed from IL105966A external-priority patent/IL105966A/en
Publication of IL113757A0 publication Critical patent/IL113757A0/en
Publication of IL113757A publication Critical patent/IL113757A/en

Links

Landscapes

  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof which comprises (i) contacting impure clavulanic acid or a salt or ester thereof in an organic solvent, with an amine of the formula R1 NR3 R2 where R1 is a group of the formula R5 N£CH2CH2NH|mCH2CH2 R4 where R4 and R5 are independently hydrogen, alkyl, amino-substituted alkyl or substituted amino-substituted alkyl, and R2 and R3 are independently hydrogen, alkyl, amino- or hydroxy-substituted alkyl or substituted amino-substituted alkyl, and m is zero or an integer 1 to 5; (ii) isolating the amine salt of clavulanic acid formed; (iii) converting the thus formed salt into clavulanic acid or a pharmaceutically acceptable salt or ester thereof. This specification was examined in accordance with regulation 35 of the Patent Regulations, 5728-1968.
IL113757A 1992-06-11 1993-06-09 Preparation of clavulanic acid IL113757A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929212379A GB9212379D0 (en) 1992-06-11 1992-06-11 Novel process
GB929222841A GB9222841D0 (en) 1992-10-31 1992-10-31 Novel process
GB929226061A GB9226061D0 (en) 1992-12-14 1992-12-14 Novel process
GB929226282A GB9226282D0 (en) 1992-12-17 1992-12-17 Novel process
IL105966A IL105966A (en) 1992-06-11 1993-06-09 Preparation of clavulanic acid

Publications (2)

Publication Number Publication Date
IL113757A0 IL113757A0 (en) 1995-08-31
IL113757A true IL113757A (en) 1997-03-18

Family

ID=27517131

Family Applications (2)

Application Number Title Priority Date Filing Date
IL113757A IL113757A (en) 1992-06-11 1993-06-09 Preparation of clavulanic acid
IL112751A IL112751A (en) 1992-06-11 1993-06-09 Preparation and/or purification of clavulanic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL112751A IL112751A (en) 1992-06-11 1993-06-09 Preparation and/or purification of clavulanic acid

Country Status (1)

Country Link
IL (2) IL113757A (en)

Also Published As

Publication number Publication date
IL112751A0 (en) 1995-05-26
IL113757A0 (en) 1995-08-31
IL112751A (en) 1997-09-30

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Legal Events

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