IL112771A - Method for the treatment of birds in interleukin 2 - Google Patents
Method for the treatment of birds in interleukin 2Info
- Publication number
- IL112771A IL112771A IL11277190A IL11277190A IL112771A IL 112771 A IL112771 A IL 112771A IL 11277190 A IL11277190 A IL 11277190A IL 11277190 A IL11277190 A IL 11277190A IL 112771 A IL112771 A IL 112771A
- Authority
- IL
- Israel
- Prior art keywords
- avian
- bird
- chicken
- administered
- vaccine
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title claims abstract description 137
- 108010002350 Interleukin-2 Proteins 0.000 title claims abstract description 137
- 238000000034 method Methods 0.000 title claims abstract description 54
- 241000271566 Aves Species 0.000 claims abstract description 77
- 229960005486 vaccine Drugs 0.000 claims abstract description 34
- 241000287828 Gallus gallus Species 0.000 claims abstract description 33
- 235000013330 chicken meat Nutrition 0.000 claims abstract description 30
- 238000011534 incubation Methods 0.000 claims abstract description 21
- 210000004027 cell Anatomy 0.000 claims description 32
- 238000002347 injection Methods 0.000 claims description 22
- 239000007924 injection Substances 0.000 claims description 22
- 241000286209 Phasianidae Species 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- 241000272517 Anseriformes Species 0.000 claims description 6
- 210000001691 amnion Anatomy 0.000 claims description 5
- 210000001325 yolk sac Anatomy 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 7
- 235000013601 eggs Nutrition 0.000 description 59
- 241000894007 species Species 0.000 description 16
- 230000000694 effects Effects 0.000 description 14
- 230000004044 response Effects 0.000 description 14
- 108010062580 Concanavalin A Proteins 0.000 description 12
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 239000003636 conditioned culture medium Substances 0.000 description 10
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 238000000338 in vitro Methods 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 230000004071 biological effect Effects 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000013642 negative control Substances 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 238000004166 bioassay Methods 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 230000009696 proliferative response Effects 0.000 description 5
- 230000009260 cross reactivity Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003226 mitogen Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 210000004989 spleen cell Anatomy 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000288147 Meleagris gallopavo Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000027312 Bursal disease Diseases 0.000 description 1
- 241001379910 Ephemera danica Species 0.000 description 1
- 102100033962 GTP-binding protein RAD Human genes 0.000 description 1
- 108050007570 GTP-binding protein Rad Proteins 0.000 description 1
- 229940124841 Herpesvirus vaccine Drugs 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 102000002067 Protein Subunits Human genes 0.000 description 1
- 108010001267 Protein Subunits Proteins 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 208000021017 Weight Gain Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- -1 igin Species 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000000994 inner shell membrane Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HOVAGTYPODGVJG-VEIUFWFVSA-N methyl alpha-D-mannoside Chemical compound CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O HOVAGTYPODGVJG-VEIUFWFVSA-N 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000993 outer shell membrane Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35752989A | 1989-05-25 | 1989-05-25 | |
| US07/372,681 US5028421A (en) | 1989-05-25 | 1989-06-27 | Method of treating birds |
| US07/469,951 US5106617A (en) | 1989-06-27 | 1990-01-25 | Method of treating immature birds with IL-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL112771A true IL112771A (en) | 1996-09-12 |
Family
ID=27408314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11277190A IL112771A (en) | 1989-05-25 | 1990-05-20 | Method for the treatment of birds in interleukin 2 |
| IL9444590A IL94445A (en) | 1989-05-25 | 1990-05-20 | Method of inducing an immature bird to gain weight |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9444590A IL94445A (en) | 1989-05-25 | 1990-05-20 | Method of inducing an immature bird to gain weight |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0473696B1 (de) |
| JP (1) | JPH04506452A (de) |
| AT (1) | ATE125449T1 (de) |
| AU (1) | AU640381B2 (de) |
| BR (1) | BR9007393A (de) |
| CA (1) | CA2057057A1 (de) |
| DE (1) | DE69021210T2 (de) |
| DK (1) | DK0473696T3 (de) |
| ES (1) | ES2074575T3 (de) |
| IL (2) | IL112771A (de) |
| WO (1) | WO1990014099A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA963309B (en) * | 1995-06-06 | 1996-10-25 | Embrex Inc | Avian immunomodulator product and method of making the same |
| CA2231603C (en) | 1995-10-17 | 2009-04-21 | Wayne State University | Chicken interleukin-15 and uses thereof |
| EP1372699A4 (de) * | 2001-02-26 | 2006-05-24 | Univ Sydney | Verfahren zur verbesserung der wachstumsleistung eines tieres |
-
1990
- 1990-05-20 IL IL11277190A patent/IL112771A/en not_active IP Right Cessation
- 1990-05-20 IL IL9444590A patent/IL94445A/en not_active IP Right Cessation
- 1990-05-22 WO PCT/US1990/002808 patent/WO1990014099A2/en not_active Ceased
- 1990-05-22 DE DE69021210T patent/DE69021210T2/de not_active Expired - Fee Related
- 1990-05-22 AT AT90908821T patent/ATE125449T1/de not_active IP Right Cessation
- 1990-05-22 EP EP90908821A patent/EP0473696B1/de not_active Expired - Lifetime
- 1990-05-22 JP JP2508522A patent/JPH04506452A/ja active Pending
- 1990-05-22 CA CA002057057A patent/CA2057057A1/en not_active Abandoned
- 1990-05-22 ES ES90908821T patent/ES2074575T3/es not_active Expired - Lifetime
- 1990-05-22 AU AU57445/90A patent/AU640381B2/en not_active Ceased
- 1990-05-22 BR BR909007393A patent/BR9007393A/pt not_active Application Discontinuation
- 1990-05-22 DK DK90908821.3T patent/DK0473696T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| AU5744590A (en) | 1990-12-18 |
| EP0473696B1 (de) | 1995-07-26 |
| DK0473696T3 (da) | 1995-12-18 |
| DE69021210D1 (de) | 1995-08-31 |
| EP0473696A1 (de) | 1992-03-11 |
| DE69021210T2 (de) | 1996-01-25 |
| WO1990014099A2 (en) | 1990-11-29 |
| ATE125449T1 (de) | 1995-08-15 |
| JPH04506452A (ja) | 1992-11-12 |
| ES2074575T3 (es) | 1995-09-16 |
| AU640381B2 (en) | 1993-08-26 |
| CA2057057A1 (en) | 1990-11-26 |
| IL94445A (en) | 1996-10-16 |
| BR9007393A (pt) | 1992-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |