IL110784A - Iontophoretic delivery device of an antimigraine drug - Google Patents
Iontophoretic delivery device of an antimigraine drugInfo
- Publication number
- IL110784A IL110784A IL11078494A IL11078494A IL110784A IL 110784 A IL110784 A IL 110784A IL 11078494 A IL11078494 A IL 11078494A IL 11078494 A IL11078494 A IL 11078494A IL 110784 A IL110784 A IL 110784A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- 6alkyl
- hydrogen
- pct
- bivalent
- Prior art date
Links
- 229940124433 antimigraine drug Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PCT No. PCT/EP94/02764 Sec. 371 Date Jan. 26, 1996 Sec. 102(e) Date Jan. 26, 1996 PCT Filed Aug. 19, 1994 PCT Pub. No. WO95/05815 PCT Pub. Date Mar. 2, 1995The present invention relates to the iontophoretic delivery to a patient, more in particular to a migraine patient, of a compound of formula (I) as shown hereinunder. The invention also relates to a device for the iontophoretic delivery of a compound of formula (I), as well as to a composition containing a compound of formula (I), which can be applied in a device for iontophoretic delivery. Said compounds are benzopyranalkylaminoalkyl substituted guanidines having the formula <IMAGE> (I) the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl; R3 is hydrogen or C1-6alkyl; or R2 and R3 taken together form a bivalent radical of formula -(CH2)m- wherein m is 4 or 5; or R1 and R2 taken together form a bivalent radical of formula -CH=CH- or of formula -(CH2)n-, wherein n is 2, 3 or 4; or R3 may represent a bond when R1 and R2 taken together form a bivalent radical of formula -CH=CH-CH=; R4 and R5 each independently are hydrogen or C1-6alkyl; Alk1 is a bivalent C1-3alkanediyl radical; Alk2 is a bivalent C2-15alkanediyl radical; and R6 and R7 each independently are hydrogen, halo, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, hydroxy, C1-6alkyloxy or cyano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202523 | 1993-08-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110784A0 IL110784A0 (en) | 1994-11-11 |
| IL110784A true IL110784A (en) | 1999-05-09 |
Family
ID=8214068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11078494A IL110784A (en) | 1993-08-27 | 1994-08-25 | Iontophoretic delivery device of an antimigraine drug |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5674871A (en) |
| EP (1) | EP0719138B1 (en) |
| JP (1) | JP2921987B2 (en) |
| KR (1) | KR100187632B1 (en) |
| CN (1) | CN1096857C (en) |
| AT (1) | ATE176591T1 (en) |
| AU (1) | AU687876B2 (en) |
| BR (1) | BR9407522A (en) |
| CA (1) | CA2168449A1 (en) |
| CZ (1) | CZ290473B6 (en) |
| DE (1) | DE69416522T2 (en) |
| DK (1) | DK0719138T3 (en) |
| ES (1) | ES2129668T3 (en) |
| FI (1) | FI960887A7 (en) |
| GR (1) | GR3029920T3 (en) |
| HR (1) | HRP940481A2 (en) |
| HU (1) | HUT75062A (en) |
| IL (1) | IL110784A (en) |
| MY (1) | MY111022A (en) |
| NO (1) | NO317628B1 (en) |
| NZ (1) | NZ273304A (en) |
| PH (1) | PH31437A (en) |
| PL (1) | PL176290B1 (en) |
| RU (1) | RU2166315C2 (en) |
| SG (1) | SG50469A1 (en) |
| SI (1) | SI9400333B (en) |
| WO (1) | WO1995005815A1 (en) |
| ZA (1) | ZA946533B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
| RU2290216C2 (en) * | 2001-04-04 | 2006-12-27 | Алза Корпорейшн | Transdermal electric-transport injection device with reservoir provided with anti-microbe compatible composition |
| WO2002089803A1 (en) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition for iontophoresis |
| JP4394444B2 (en) * | 2001-10-24 | 2010-01-06 | パワー ペーパー リミティド | Devices and methods for controlled intradermal delivery of active agents |
| ITMI20021200A1 (en) * | 2002-06-03 | 2003-12-03 | Gafitex S R L | FABRIC SUITABLE FOR EXPLICATING A BARRIER EFFECT AGAINST MAGNETIC AND ELECTROMAGNETIC FIELDS AND / OR METALLOTHERAPY EFFECTS |
| US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
| US20050220439A1 (en) * | 2004-03-19 | 2005-10-06 | Carton Owen A | Interactive multimedia system and method |
| WO2007009462A2 (en) * | 2005-07-15 | 2007-01-25 | Region Hovedstaden V/Glostrup Hospital | Treatment of migraine and headaches |
| GB2430364A (en) * | 2005-09-22 | 2007-03-28 | Carl Ernest Alexander | Soft agar bolus for oral drug delivery |
| EA023147B1 (en) * | 2006-04-13 | 2016-04-29 | Тева Фармасьютикалс Интернешнл Гмбх | Transdermal patch for treating migraine |
| RU2352359C1 (en) * | 2007-10-24 | 2009-04-20 | Общество с ограниченнной ответственностью "НПО Текстильпрогресс Инженерной Академии " (ООО "НПО Текстильпрогресс ИА") | Method of composition creation for medical preparation delivery in organism cavity at diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4028125A1 (en) * | 1990-01-17 | 1991-07-18 | Klimke Markus | Application plaster for regulated dosing of various pharmacons - uses electrical correct for percutaneous transport for local and systematic therapy |
| WO1991015260A1 (en) * | 1990-03-30 | 1991-10-17 | Alza Corporation | Device and method for iontophoretic drug delivery |
| SI9300097B (en) * | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
-
1994
- 1994-07-15 PH PH48643A patent/PH31437A/en unknown
- 1994-08-19 DK DK94926855T patent/DK0719138T3/en active
- 1994-08-19 DE DE69416522T patent/DE69416522T2/en not_active Expired - Fee Related
- 1994-08-19 CN CN94193196A patent/CN1096857C/en not_active Expired - Fee Related
- 1994-08-19 AU AU76542/94A patent/AU687876B2/en not_active Ceased
- 1994-08-19 JP JP7507338A patent/JP2921987B2/en not_active Expired - Fee Related
- 1994-08-19 CA CA002168449A patent/CA2168449A1/en not_active Abandoned
- 1994-08-19 WO PCT/EP1994/002764 patent/WO1995005815A1/en not_active Ceased
- 1994-08-19 ES ES94926855T patent/ES2129668T3/en not_active Expired - Lifetime
- 1994-08-19 EP EP94926855A patent/EP0719138B1/en not_active Expired - Lifetime
- 1994-08-19 CZ CZ1996570A patent/CZ290473B6/en not_active IP Right Cessation
- 1994-08-19 HU HU9600471A patent/HUT75062A/en unknown
- 1994-08-19 RU RU96105930/14A patent/RU2166315C2/en not_active IP Right Cessation
- 1994-08-19 AT AT94926855T patent/ATE176591T1/en not_active IP Right Cessation
- 1994-08-19 PL PL94313255A patent/PL176290B1/en not_active IP Right Cessation
- 1994-08-19 KR KR1019960700410A patent/KR100187632B1/en not_active Expired - Fee Related
- 1994-08-19 SG SG1996002184A patent/SG50469A1/en unknown
- 1994-08-19 BR BR9407522A patent/BR9407522A/en not_active Application Discontinuation
- 1994-08-19 US US08/586,700 patent/US5674871A/en not_active Expired - Fee Related
- 1994-08-19 NZ NZ273304A patent/NZ273304A/en unknown
- 1994-08-25 IL IL11078494A patent/IL110784A/en not_active IP Right Cessation
- 1994-08-25 MY MYPI94002234A patent/MY111022A/en unknown
- 1994-08-26 HR HR93.202.523.2A patent/HRP940481A2/en not_active Application Discontinuation
- 1994-08-26 ZA ZA946533A patent/ZA946533B/en unknown
- 1994-08-26 SI SI9400333A patent/SI9400333B/en not_active IP Right Cessation
-
1996
- 1996-02-26 FI FI960887A patent/FI960887A7/en not_active Application Discontinuation
- 1996-02-26 NO NO19960769A patent/NO317628B1/en unknown
-
1999
- 1999-04-07 GR GR990401012T patent/GR3029920T3/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |