IL109470A0 - Water soluble camptothecin derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Water soluble camptothecin derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109470A0
IL109470A0 IL10947094A IL10947094A IL109470A0 IL 109470 A0 IL109470 A0 IL 109470A0 IL 10947094 A IL10947094 A IL 10947094A IL 10947094 A IL10947094 A IL 10947094A IL 109470 A0 IL109470 A0 IL 109470A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
water soluble
compositions containing
camptothecin derivatives
Prior art date
Application number
IL10947094A
Other languages
English (en)
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of IL109470A0 publication Critical patent/IL109470A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
IL10947094A 1993-04-29 1994-04-28 Water soluble camptothecin derivatives, their preparation and pharmaceutical compositions containing them IL109470A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5458593A 1993-04-29 1993-04-29
US8104293A 1993-06-22 1993-06-22

Publications (1)

Publication Number Publication Date
IL109470A0 true IL109470A0 (en) 1994-07-31

Family

ID=26733234

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10947094A IL109470A0 (en) 1993-04-29 1994-04-28 Water soluble camptothecin derivatives, their preparation and pharmaceutical compositions containing them

Country Status (10)

Country Link
EP (1) EP0696285A1 (de)
JP (1) JPH08509740A (de)
AP (1) AP9400638A0 (de)
AU (1) AU6777194A (de)
CA (1) CA2161681A1 (de)
IL (1) IL109470A0 (de)
IS (1) IS4152A (de)
MY (1) MY141374A (de)
PE (1) PE52894A1 (de)
WO (1) WO1994025466A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
SG103322A1 (en) * 1996-10-30 2004-04-29 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
IN189180B (de) * 1997-07-09 2003-01-04 Chong Kun Dang Corp
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0418099T3 (da) * 1989-09-15 2002-04-02 Res Triangle Inst Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
EP0540099B1 (de) * 1991-10-29 1996-04-17 Glaxo Wellcome Inc. Wasserlösliche Camptothecinderivate
CA2087898A1 (en) * 1992-01-24 1993-07-25 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
IS4152A (is) 1994-10-30
PE52894A1 (es) 1995-01-06
EP0696285A1 (de) 1996-02-14
CA2161681A1 (en) 1994-11-10
AU6777194A (en) 1994-11-21
WO1994025466A1 (en) 1994-11-10
AP9400638A0 (en) 1995-10-28
MY141374A (en) 2010-04-16
JPH08509740A (ja) 1996-10-15

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