IL103271A0 - Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them - Google Patents
Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing themInfo
- Publication number
- IL103271A0 IL103271A0 IL103271A IL10327192A IL103271A0 IL 103271 A0 IL103271 A0 IL 103271A0 IL 103271 A IL103271 A IL 103271A IL 10327192 A IL10327192 A IL 10327192A IL 103271 A0 IL103271 A0 IL 103271A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- benzo
- alkylamino
- alkanoylamino
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
New 1,8-benzo[b]naphthyridine derivative of general formula: <IMAGE> in which R is H or a hydroxyl, amino or alkylamino radical, the alkylamino radical optionally being substituted with amino or hydroxyl, or R is dialkylamino in which the alkyl parts may form, with the nitrogen atom, a 5- or 6-membered heterocycle optionally containing another heteroatom chosen from nitrogen, oxygen or sulphur, or R is cycloalkylamino (3 to 6C), or an alkanoylamino, N-alkyl-N-alkanoylamino or aminoalkylphenylamino radical, R1 and R2, which are identical or different, are in position 2 and 3 and represent H, alkyl, alkenyl (2 to 4C), phenyl or substituted phenyl, or else R1 and R2 are in position 2 and represent alkyl, R3 is H or alkyl, fluoroalkyl, carboxyalkyl, cycloalkyl containing 3 to 6 carbon atoms, fluorophenyl, difluorophenyl, alkyloxy or alkylamino, and R4 is H or F, the alkyl and alkanoyl (1 to 4C) radicals being straight or branched, in its stereoisomeric forms or their mixtures as well as its salts and its hydrated forms. These new derivatives are useful as antimicrobial agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9112058A FR2681865B1 (en) | 1991-10-01 | 1991-10-01 | NOVEL BENZONAPHTYRIDINE-1,8 DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL103271A0 true IL103271A0 (en) | 1993-02-21 |
| IL103271A IL103271A (en) | 1996-03-31 |
Family
ID=9417466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10327192A IL103271A (en) | 1991-10-01 | 1992-09-24 | 8-azetidino-7-fluoro-1,4-dihydro-4-oxo-benzo (1,8) naphthyridine-3-carboxylic acid derivatives their preparation and compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0606382B1 (en) |
| JP (1) | JPH07501047A (en) |
| AT (1) | ATE166054T1 (en) |
| AU (1) | AU665787B2 (en) |
| CA (1) | CA2119755A1 (en) |
| CZ (1) | CZ282257B6 (en) |
| DE (1) | DE69225490D1 (en) |
| FI (1) | FI941517A (en) |
| FR (1) | FR2681865B1 (en) |
| GE (1) | GEP19981300B (en) |
| HU (1) | HU214599B (en) |
| IL (1) | IL103271A (en) |
| MX (1) | MX9205539A (en) |
| NO (1) | NO300327B1 (en) |
| NZ (1) | NZ244518A (en) |
| PL (1) | PL170866B1 (en) |
| RU (1) | RU2105006C1 (en) |
| SK (1) | SK37394A3 (en) |
| TW (1) | TW263510B (en) |
| WO (1) | WO1993007144A1 (en) |
| YU (1) | YU48244B (en) |
| ZA (1) | ZA927455B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2682384B1 (en) * | 1991-10-10 | 1995-04-07 | Bellon Laboratoires | PROCESS FOR THE PREPARATION OF BENZO (B) NAPHTYRIDINES. |
| GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| FR2787452B1 (en) * | 1998-12-21 | 2004-10-22 | Aventis Pharma Sa | NOVEL BENZONAPHTYRIDINE-1,8 DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| PT1140932E (en) | 1998-12-21 | 2004-08-31 | Aventis Pharma Sa | 1,8-BENZONETHYRIDINE DERIVATIVES |
| WO2000063168A1 (en) * | 1999-04-16 | 2000-10-26 | Coelacanth Chemical Corporation | Synthesis of azetidine derivatives |
| US6355631B1 (en) * | 2000-03-03 | 2002-03-12 | Aventis Pharma S.A. | Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation |
| TWI520963B (en) | 2014-12-24 | 2016-02-11 | 國立清華大學 | 1,9-diazaphenalene derivatives and making the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO177302C (en) * | 1989-03-16 | 1995-08-23 | Esteve Labor Dr | Analogous Process for Preparing Therapeutically Active Substituted Azetidinyl Quinolone (Naphthyridone) Carboxylic Acid Derivatives |
| RO108347B1 (en) * | 1989-10-30 | 1994-04-28 | Bellon Labor Sa Roger | DERIVATES OF BENZ(b)- NAPHTYRIDINE-1,8 AND PREPARATION PROCESS THEREFOR |
-
1991
- 1991-10-01 FR FR9112058A patent/FR2681865B1/en not_active Expired - Fee Related
-
1992
- 1992-09-24 IL IL10327192A patent/IL103271A/en not_active IP Right Cessation
- 1992-09-28 NZ NZ244518A patent/NZ244518A/en unknown
- 1992-09-29 WO PCT/FR1992/000901 patent/WO1993007144A1/en active IP Right Grant
- 1992-09-29 CZ CZ94752A patent/CZ282257B6/en unknown
- 1992-09-29 RU RU94019969A patent/RU2105006C1/en active
- 1992-09-29 ZA ZA927455A patent/ZA927455B/en unknown
- 1992-09-29 EP EP92921665A patent/EP0606382B1/en not_active Expired - Lifetime
- 1992-09-29 AU AU27860/92A patent/AU665787B2/en not_active Ceased
- 1992-09-29 TW TW081107683A patent/TW263510B/zh active
- 1992-09-29 JP JP5506650A patent/JPH07501047A/en active Pending
- 1992-09-29 DE DE69225490T patent/DE69225490D1/en not_active Expired - Lifetime
- 1992-09-29 HU HU9400941A patent/HU214599B/en not_active IP Right Cessation
- 1992-09-29 SK SK373-94A patent/SK37394A3/en unknown
- 1992-09-29 PL PL92303093A patent/PL170866B1/en unknown
- 1992-09-29 AT AT92921665T patent/ATE166054T1/en not_active IP Right Cessation
- 1992-09-29 MX MX9205539A patent/MX9205539A/en not_active IP Right Cessation
- 1992-09-29 EP EP92402655A patent/EP0536035A1/en active Pending
- 1992-09-29 CA CA002119755A patent/CA2119755A1/en not_active Abandoned
- 1992-09-29 GE GEAP19922400A patent/GEP19981300B/en unknown
- 1992-10-01 YU YU88192A patent/YU48244B/en unknown
-
1994
- 1994-03-22 NO NO941035A patent/NO300327B1/en unknown
- 1994-03-31 FI FI941517A patent/FI941517A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2105006C1 (en) | 1998-02-20 |
| HUT72463A (en) | 1996-04-29 |
| HU214599B (en) | 1998-04-28 |
| NO300327B1 (en) | 1997-05-12 |
| CZ75294A3 (en) | 1994-07-13 |
| WO1993007144A1 (en) | 1993-04-15 |
| JPH07501047A (en) | 1995-02-02 |
| IL103271A (en) | 1996-03-31 |
| GEP19981300B (en) | 1998-05-01 |
| HU9400941D0 (en) | 1994-06-28 |
| YU48244B (en) | 1997-08-22 |
| FR2681865B1 (en) | 1993-11-19 |
| NZ244518A (en) | 1994-04-27 |
| ZA927455B (en) | 1993-04-07 |
| PL170866B1 (en) | 1997-01-31 |
| ATE166054T1 (en) | 1998-05-15 |
| NO941035L (en) | 1994-03-22 |
| EP0536035A1 (en) | 1993-04-07 |
| MX9205539A (en) | 1993-04-01 |
| AU665787B2 (en) | 1996-01-18 |
| YU88192A (en) | 1995-10-03 |
| AU2786092A (en) | 1993-05-03 |
| SK37394A3 (en) | 1994-12-07 |
| TW263510B (en) | 1995-11-21 |
| NO941035D0 (en) | 1994-03-22 |
| CZ282257B6 (en) | 1997-06-11 |
| CA2119755A1 (en) | 1993-04-15 |
| FI941517A0 (en) | 1994-03-31 |
| EP0606382B1 (en) | 1998-05-13 |
| EP0606382A1 (en) | 1994-07-20 |
| FR2681865A1 (en) | 1993-04-02 |
| DE69225490D1 (en) | 1998-06-18 |
| FI941517A (en) | 1994-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |