IL100097A0 - Pyridyl derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Pyridyl derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL100097A0 IL100097A0 IL100097A IL10009791A IL100097A0 IL 100097 A0 IL100097 A0 IL 100097A0 IL 100097 A IL100097 A IL 100097A IL 10009791 A IL10009791 A IL 10009791A IL 100097 A0 IL100097 A0 IL 100097A0
- Authority
- IL
- Israel
- Prior art keywords
- thromboxane
- addition
- preparation
- pyridyl derivatives
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Paper (AREA)
Abstract
The present invention relates to novel pyridyl derivatives of the general formula <IMAGE> in which R1 to R6, A, X and n are as defined in Claim 1, their enantiomers, their cis- and trans-isomers if R4 and R5 together represent a carbon-carbon bond, and their addition salts, for pharmaceutical use, in particular, their physiologically tolerable addition salts with inorganic or organic bases, if R6 represents a hydroxyl group, which have useful pharmacological properties, in particular antithrombotic effects and effects mediated by thromboxane. In addition, the novel compounds are at the same time thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). In addition, they also have an effect on PGE2 production.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4037112A DE4037112A1 (en) | 1990-11-22 | 1990-11-22 | NEW PYRIDYL DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
IL100097A0 true IL100097A0 (en) | 1992-08-18 |
IL100097A IL100097A (en) | 1995-07-31 |
Family
ID=6418696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10009791A IL100097A (en) | 1990-11-22 | 1991-11-20 | Pyridyl derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0487095B1 (en) |
JP (1) | JPH04275273A (en) |
KR (1) | KR920009799A (en) |
AT (1) | ATE134619T1 (en) |
AU (1) | AU640063B2 (en) |
CA (1) | CA2055950A1 (en) |
DE (2) | DE4037112A1 (en) |
DK (1) | DK0487095T3 (en) |
ES (1) | ES2084756T3 (en) |
FI (1) | FI915484A (en) |
GR (1) | GR3019783T3 (en) |
HU (1) | HU213676B (en) |
IE (1) | IE74248B1 (en) |
IL (1) | IL100097A (en) |
NO (1) | NO175634C (en) |
NZ (1) | NZ240677A (en) |
PT (1) | PT99571B (en) |
RU (1) | RU2028292C1 (en) |
ZA (1) | ZA919205B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4216364A1 (en) * | 1991-12-14 | 1993-11-25 | Thomae Gmbh Dr K | Pyridyl derivs. with antithrombotic properties |
TWI290549B (en) * | 2000-06-02 | 2007-12-01 | Astrazeneca Ab | Process for the preparation of cyclopropyl carboxylic acid ester and derivatives |
DE10225635C1 (en) * | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-benzoylureido-cinnamic acid derivatives, process for their preparation and their use |
FI20055498A0 (en) * | 2005-09-16 | 2005-09-16 | Biotie Therapies Corp | Sulfonamides |
EP2928860A1 (en) * | 2012-12-10 | 2015-10-14 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4518602A (en) * | 1982-10-07 | 1985-05-21 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase |
GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
DE3932403A1 (en) * | 1989-05-12 | 1991-04-11 | Thomae Gmbh Dr K | NEW ARYLSULFONAMIDES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
-
1990
- 1990-11-22 DE DE4037112A patent/DE4037112A1/en not_active Withdrawn
-
1991
- 1991-11-19 AU AU87964/91A patent/AU640063B2/en not_active Ceased
- 1991-11-20 NZ NZ240677A patent/NZ240677A/en unknown
- 1991-11-20 IL IL10009791A patent/IL100097A/en not_active IP Right Cessation
- 1991-11-21 CA CA002055950A patent/CA2055950A1/en not_active Abandoned
- 1991-11-21 IE IE404891A patent/IE74248B1/en not_active IP Right Cessation
- 1991-11-21 EP EP91119889A patent/EP0487095B1/en not_active Expired - Lifetime
- 1991-11-21 KR KR1019910020776A patent/KR920009799A/en active IP Right Grant
- 1991-11-21 FI FI915484A patent/FI915484A/en not_active Application Discontinuation
- 1991-11-21 PT PT99571A patent/PT99571B/en not_active IP Right Cessation
- 1991-11-21 DE DE59107462T patent/DE59107462D1/en not_active Expired - Fee Related
- 1991-11-21 HU HU913644A patent/HU213676B/en not_active IP Right Cessation
- 1991-11-21 DK DK91119889.3T patent/DK0487095T3/en active
- 1991-11-21 NO NO914567A patent/NO175634C/en unknown
- 1991-11-21 RU SU915010111A patent/RU2028292C1/en active
- 1991-11-21 ES ES91119889T patent/ES2084756T3/en not_active Expired - Lifetime
- 1991-11-21 JP JP3305990A patent/JPH04275273A/en active Pending
- 1991-11-21 AT AT91119889T patent/ATE134619T1/en not_active IP Right Cessation
- 1991-11-21 ZA ZA919205A patent/ZA919205B/en unknown
-
1996
- 1996-04-29 GR GR960401163T patent/GR3019783T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE74248B1 (en) | 1997-07-16 |
ES2084756T3 (en) | 1996-05-16 |
KR920009799A (en) | 1992-06-25 |
PT99571B (en) | 1999-04-30 |
GR3019783T3 (en) | 1996-07-31 |
HU213676B (en) | 1997-09-29 |
RU2028292C1 (en) | 1995-02-09 |
EP0487095A1 (en) | 1992-05-27 |
NO175634C (en) | 1994-11-09 |
HU913644D0 (en) | 1992-02-28 |
HUT60472A (en) | 1992-09-28 |
NO914567D0 (en) | 1991-11-21 |
DE4037112A1 (en) | 1992-05-27 |
ZA919205B (en) | 1993-05-21 |
IE914048A1 (en) | 1992-06-03 |
DK0487095T3 (en) | 1996-06-24 |
AU8796491A (en) | 1992-05-28 |
ATE134619T1 (en) | 1996-03-15 |
NO175634B (en) | 1994-08-01 |
NO914567L (en) | 1992-05-25 |
IL100097A (en) | 1995-07-31 |
AU640063B2 (en) | 1993-08-12 |
JPH04275273A (en) | 1992-09-30 |
NZ240677A (en) | 1994-12-22 |
FI915484A0 (en) | 1991-11-21 |
FI915484A (en) | 1992-05-23 |
DE59107462D1 (en) | 1996-04-04 |
PT99571A (en) | 1992-10-30 |
CA2055950A1 (en) | 1992-05-23 |
EP0487095B1 (en) | 1996-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |