IES950207A2 - Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylamines - Google Patents
Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylaminesInfo
- Publication number
- IES950207A2 IES950207A2 IES950207A IES950207A2 IE S950207 A2 IES950207 A2 IE S950207A2 IE S950207 A IES950207 A IE S950207A IE S950207 A2 IES950207 A2 IE S950207A2
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- dimethylpropylamines
- racemic
- pyridyl
- phenyl
- Prior art date
Links
- IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical class C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 3,5-disubstituted benzoic acid Chemical class 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing in essentially pure form the d-isomer of a compound of the formula I <CHEM 1> wherein X is chlorine and n is 0 or 1, or a pharmaceutically acceptable addition salt thereof, comprises reacting the dl-form of a compound formula I with a 3,5-disubstituted benzoic acid as resolving agent and, if desired, converting the compound thus obtained into a pharmaceutically acceptable acid addition salt thereof. These compounds have strong anti-histamine activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES950207 IES950207A2 (en) | 1995-03-23 | 1995-03-23 | Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylamines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES950207 IES950207A2 (en) | 1995-03-23 | 1995-03-23 | Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES64896B2 IES64896B2 (en) | 1995-09-20 |
| IES950207A2 true IES950207A2 (en) | 1995-09-20 |
Family
ID=11040690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES950207 IES950207A2 (en) | 1995-03-23 | 1995-03-23 | Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylamines |
Country Status (1)
| Country | Link |
|---|---|
| IE (1) | IES950207A2 (en) |
-
1995
- 1995-03-23 IE IES950207 patent/IES950207A2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IES64896B2 (en) | 1995-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |