IES20180078A2 - Pharmaceutical raw materials hexafluoroacetone synthesis method - Google Patents

Pharmaceutical raw materials hexafluoroacetone synthesis method

Info

Publication number
IES20180078A2
IES20180078A2 IES20180078A IES20180078A IES20180078A2 IE S20180078 A2 IES20180078 A2 IE S20180078A2 IE S20180078 A IES20180078 A IE S20180078A IE S20180078 A IES20180078 A IE S20180078A IE S20180078 A2 IES20180078 A2 IE S20180078A2
Authority
IE
Ireland
Prior art keywords
hexafluoroacetone
raw materials
synthesis method
solution
pharmaceutical raw
Prior art date
Application number
IES20180078A
Inventor
Yan Yida
Original Assignee
Chengdu Dong Dian Ai Er Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Dong Dian Ai Er Tech Co Ltd filed Critical Chengdu Dong Dian Ai Er Tech Co Ltd
Publication of IES20180078A2 publication Critical patent/IES20180078A2/en
Publication of IES86972B2 publication Critical patent/IES86972B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pharmaceutical raw materials hexafluoroacetone synthesis method, comprises the following steps: 3 mol 2,3-dihydroxy-hexafluoroisopentane and 4-6 mol N-methylpropionamide were added to the reaction vessel, raised the temperature of the solution to 70-80°C for 60-80 min, then added 2-3 mol bismuth molybdate, continued to react for 50-70 min, reduced the temperature to 40-50°C, vacuum distillation, collected the fractions of 80-89°C, washed with m-cresol solution, washed with m-chloroaniline solution, recrystallized in the methoxy toluene solution, and got the finished product hexafluoroacetone.
IES20180078A 2017-04-05 2018-03-27 Pharmaceutical raw materials hexafluoroacetone synthesis method IES86972B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710215443.6A CN108238870A (en) 2017-04-05 2017-04-05 A kind of synthetic method of medical material Hexafluoro acetone

Publications (2)

Publication Number Publication Date
IES20180078A2 true IES20180078A2 (en) 2019-04-03
IES86972B2 IES86972B2 (en) 2019-05-01

Family

ID=58744602

Family Applications (1)

Application Number Title Priority Date Filing Date
IES20180078A IES86972B2 (en) 2017-04-05 2018-03-27 Pharmaceutical raw materials hexafluoroacetone synthesis method

Country Status (4)

Country Link
CN (1) CN108238870A (en)
AU (1) AU2018100416A4 (en)
GB (1) GB201705850D0 (en)
IE (1) IES86972B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113527975A (en) * 2021-07-28 2021-10-22 上海涂固安高科技有限公司 Water-based fluorine-containing coating and preparation method thereof

Also Published As

Publication number Publication date
IES86972B2 (en) 2019-05-01
CN108238870A (en) 2018-07-03
AU2018100416A4 (en) 2018-05-10
GB201705850D0 (en) 2017-05-24

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