IE922401L - An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia - Google Patents

An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia

Info

Publication number
IE922401L
IE922401L IE922401A IE922401A IE922401L IE 922401 L IE922401 L IE 922401L IE 922401 A IE922401 A IE 922401A IE 922401 A IE922401 A IE 922401A IE 922401 L IE922401 L IE 922401L
Authority
IE
Ireland
Prior art keywords
c2h4o
composition
approximately
fibrinolytic
ischemia
Prior art date
Application number
IE922401A
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/045,459 external-priority patent/US4801452A/en
Application filed by Univ Emory filed Critical Univ Emory
Publication of IE922401L publication Critical patent/IE922401L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator

Abstract

"IMPROVED FIBRINOLYTIC COMPOSITION" of the Invention In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound. [CA1297792C]
IE922401A 1986-05-15 1987-05-14 An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia IE922401L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86358286A 1986-05-15 1986-05-15
US07/045,459 US4801452A (en) 1986-05-15 1987-05-07 Fibrinolytic composition

Publications (1)

Publication Number Publication Date
IE922401L true IE922401L (en) 1987-11-15

Family

ID=26722792

Family Applications (4)

Application Number Title Priority Date Filing Date
IE922399A IE922399L (en) 1986-05-15 1987-05-14 An ex vivo tissue perfusion composition and the use thereof
IE922401A IE922401L (en) 1986-05-15 1987-05-14 An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia
IE126187A IE62088B1 (en) 1986-05-15 1987-05-14 Fibrinolytic composition
IE922400A IE922400L (en) 1986-05-15 1987-05-14 Composition comprising an oxygen radical scavenger and a¹surface-active copolymer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE922399A IE922399L (en) 1986-05-15 1987-05-14 An ex vivo tissue perfusion composition and the use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IE126187A IE62088B1 (en) 1986-05-15 1987-05-14 Fibrinolytic composition
IE922400A IE922400L (en) 1986-05-15 1987-05-14 Composition comprising an oxygen radical scavenger and a¹surface-active copolymer

Country Status (6)

Country Link
CA (1) CA1297792C (en)
GR (1) GR870758B (en)
IE (4) IE922399L (en)
NZ (1) NZ220288A (en)
PH (1) PH25909A (en)
PT (1) PT84880B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2120561A4 (en) 2007-02-19 2012-11-21 Plurogen Therapeutics Inc Compositions for treating biofilms and methods for using same
WO2016118644A1 (en) 2015-01-20 2016-07-28 Plurogen Therapeutics, Llc Compositions and methods of treating microbes

Also Published As

Publication number Publication date
IE922400L (en) 1987-11-15
IE62088B1 (en) 1994-12-14
GR870758B (en) 1988-05-24
CA1297792C (en) 1992-03-24
IE922399L (en) 1987-11-15
PT84880A (en) 1987-06-01
PT84880B (en) 1990-02-08
IE871261L (en) 1987-11-15
PH25909A (en) 1991-12-19
NZ220288A (en) 1989-08-29

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Legal Events

Date Code Title Description
FA9A Application withdrawn section 33(1)