IE831646L - Vinca alkaloid compositions. - Google Patents

Vinca alkaloid compositions.

Info

Publication number
IE831646L
IE831646L IE831646A IE164683A IE831646L IE 831646 L IE831646 L IE 831646L IE 831646 A IE831646 A IE 831646A IE 164683 A IE164683 A IE 164683A IE 831646 L IE831646 L IE 831646L
Authority
IE
Ireland
Prior art keywords
vinca
vinca alkaloid
alkaloid compositions
leuraformine
gb2125292a
Prior art date
Application number
IE831646A
Other versions
IE55388B1 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE831646L publication Critical patent/IE831646L/en
Publication of IE55388B1 publication Critical patent/IE55388B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides stable, sterile, ready-to-use formulations of oncolytic vinca dimers comprising an aqueous solution of the vinca dimer (e.g. vincristine, vinblastine, vindesine, 4 min -deoxy-1-formyl-leurosidine or leuraformine) as a pharmaceutically acceptable water-soluble salt, an acetate buffer maintaining the pH between 3.0 and 5.0, a polyol (e.g. lactose, mannitol, sorbitol), and a preservative which is preferably methyl paraben and/or propyl paraben. [GB2125292A]
IE1646/83A 1982-07-19 1983-07-15 Stable pharmaceutical solutions of vinca alkaloids IE55388B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39965482A 1982-07-19 1982-07-19
US47607783A 1983-03-17 1983-03-17

Publications (2)

Publication Number Publication Date
IE831646L true IE831646L (en) 1984-01-19
IE55388B1 IE55388B1 (en) 1990-08-29

Family

ID=27016716

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1646/83A IE55388B1 (en) 1982-07-19 1983-07-15 Stable pharmaceutical solutions of vinca alkaloids

Country Status (16)

Country Link
AU (1) AU553514B2 (en)
BE (1) BE897280A (en)
CH (1) CH654744A5 (en)
DE (1) DE3324964A1 (en)
FR (1) FR2531860B1 (en)
GB (1) GB2125292B (en)
HK (1) HK43087A (en)
HU (1) HU191538B (en)
IE (1) IE55388B1 (en)
IL (1) IL69203A (en)
IT (1) IT1170152B (en)
LU (1) LU84910A1 (en)
NL (1) NL184146C (en)
NZ (1) NZ204868A (en)
PH (1) PH19098A (en)
SE (1) SE463804B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
FR2597750B1 (en) * 1986-04-25 1989-06-02 Pf Medicament STABLE AQUEOUS SOLUTION OF VINCRISTINE SULFATE
FR2623089B1 (en) * 1987-11-13 1990-04-27 Pf Medicament PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION OF NAVELBINE
US4923876A (en) * 1988-04-18 1990-05-08 Cetus Corporation Vinca alkaloid pharmaceutical compositions
HU204995B (en) * 1989-11-07 1992-03-30 Richter Gedeon Vegyeszet Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes
FR2910812B1 (en) 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa LYOPHILIZED INJECTABLE PHARMACEUTICAL COMPOSITIONS OF HEMI-SYNTHETIC STABLE VINCA ALKALOID DERIVATIVES AT AMBIENT TEMPERATURE
EP3777861A1 (en) * 2015-08-01 2021-02-17 Sun Pharmaceutical Industries Ltd Dosage form of vinca alkaloid drug

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3749784A (en) * 1972-05-03 1973-07-31 Lilly Co Eli Psoriasis treatment
GB2020180B (en) * 1978-05-08 1982-08-25 Nelson Res & Dev Ophthalmic compositions containingcolchicine or vinblastinr
US4208414A (en) * 1978-06-05 1980-06-17 Eli Lilly And Company Vinblastine in rheumatoid arthritis
US4259242A (en) * 1978-10-10 1981-03-31 Eli Lilly And Company Method of preparing vindesine sulfate
HU181940B (en) * 1979-11-02 1983-11-28 Richter Gedeon Vegyeszet Process for producing solutions of vincane derivatives for parentheral application
OA06421A (en) * 1980-06-10 1981-09-30 Omnium Chimique Sa Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.

Also Published As

Publication number Publication date
NL184146B (en) 1988-12-01
AU553514B2 (en) 1986-07-17
NL8302552A (en) 1984-02-16
GB2125292B (en) 1986-06-04
LU84910A1 (en) 1985-04-17
NZ204868A (en) 1986-10-08
PH19098A (en) 1986-01-02
IT1170152B (en) 1987-06-03
IL69203A (en) 1986-03-31
FR2531860A1 (en) 1984-02-24
NL184146C (en) 1989-05-01
HK43087A (en) 1987-06-05
GB2125292A (en) 1984-03-07
DE3324964A1 (en) 1984-01-19
AU1689183A (en) 1984-01-26
HU191538B (en) 1987-03-30
IE55388B1 (en) 1990-08-29
IT8321644A0 (en) 1983-06-15
SE463804B (en) 1991-01-28
SE8304009L (en) 1984-01-20
SE8304009D0 (en) 1983-07-15
FR2531860B1 (en) 1986-09-26
DE3324964C2 (en) 1991-03-14
BE897280A (en) 1984-01-13
GB8319146D0 (en) 1983-08-17
IL69203A0 (en) 1983-11-30
CH654744A5 (en) 1986-03-14

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Legal Events

Date Code Title Description
MK9A Patent expired