IE810967L - Enzyme inhibitor - Google Patents
Enzyme inhibitorInfo
- Publication number
- IE810967L IE810967L IE810967A IE96781A IE810967L IE 810967 L IE810967 L IE 810967L IE 810967 A IE810967 A IE 810967A IE 96781 A IE96781 A IE 96781A IE 810967 L IE810967 L IE 810967L
- Authority
- IE
- Ireland
- Prior art keywords
- lysyl
- hydrogen
- cyclopentanecarbonyl
- dehydroproline
- phenylalanyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inhibitors of angiotensin converting enzyme which are physiologically tolerated salts of compounds of the general formula (I) in which R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert- butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L- glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl, A is phenylalanyl, glycyl, alanyl, tryptophyl, tyrosyl, isoleucyl, leucyl, histidyl or valyl, where the alpha- amino group of these radicals is bonded in the form of an amide bond to the radical R having a meaning other than hydrogen, and phenylalanyl is racemic if R is benzoyl, R1 is hydrogen or methyl, R2 -COOH, L-proline, L-3,4- dehydroproline, D,L-3,4-dehydroproline, L-3- hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4- carboxylic acid or L-5-oxoproline, where the imino group in these radicals is bonded to the adjacent group, Kat is the cation of a base, and n is zero or 1, where R1 is methyl if n is zero. <IMAGE>
[AT390796B]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/156,749 US4692437A (en) | 1978-09-11 | 1980-06-05 | Anti-hypertensive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE810967L true IE810967L (en) | 1981-12-05 |
| IE51739B1 IE51739B1 (en) | 1987-03-18 |
Family
ID=22560916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE967/81A IE51739B1 (en) | 1980-06-05 | 1981-04-30 | Anti-hypertensive agents |
Country Status (6)
| Country | Link |
|---|---|
| KR (1) | KR830005115A (en) |
| AT (1) | AT390796B (en) |
| DD (1) | DD159426A5 (en) |
| ES (1) | ES8203332A2 (en) |
| IE (1) | IE51739B1 (en) |
| PL (1) | PL231471A3 (en) |
-
1981
- 1981-04-28 ES ES501730A patent/ES8203332A2/en not_active Expired
- 1981-04-30 KR KR1019810001495A patent/KR830005115A/en unknown
- 1981-04-30 IE IE967/81A patent/IE51739B1/en not_active IP Right Cessation
- 1981-05-08 AT AT0205181A patent/AT390796B/en not_active IP Right Cessation
- 1981-06-03 PL PL23147181A patent/PL231471A3/xx unknown
- 1981-06-04 DD DD81230574A patent/DD159426A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL231471A3 (en) | 1982-03-01 |
| AT390796B (en) | 1990-06-25 |
| DD159426A5 (en) | 1983-03-09 |
| ES501730A0 (en) | 1982-04-01 |
| IE51739B1 (en) | 1987-03-18 |
| ES8203332A2 (en) | 1982-04-01 |
| ATA205181A (en) | 1989-12-15 |
| KR830005115A (en) | 1983-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |