IE790126L - Heterocycle-substituted guanidine derivatives - Google Patents

Heterocycle-substituted guanidine derivatives

Info

Publication number
IE790126L
IE790126L IE790126A IE12679A IE790126L IE 790126 L IE790126 L IE 790126L IE 790126 A IE790126 A IE 790126A IE 12679 A IE12679 A IE 12679A IE 790126 L IE790126 L IE 790126L
Authority
IE
Ireland
Prior art keywords
carbon atoms
heterocycle
alkyl
guanidine derivatives
hydrogen
Prior art date
Application number
IE790126A
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE790126L publication Critical patent/IE790126L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Abstract

Compounds of formula I, <IMAGE> wherein R1, R2 and R3 are, independently, hydrogen, halogen or alkyl of 1 to 4 carbon atoms, and either R4 and R6 are independently hydrogen, alkyl or hydroxyalkyl, each of 1 to 4 carbon atoms, or alkoxyalkyl with a maximum of 6 carbon atoms, or R4 and R6 together signify dimethylene or trimethylene, R5 and R7 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, and X is sulphur, oxygen, imino, or (C1-4) alkylimino, are useful as antihypertensive agents. [GB2013192A]
IE790126A 1978-01-25 1979-01-30 Heterocycle-substituted guanidine derivatives IE790126L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH79978 1978-01-25

Publications (1)

Publication Number Publication Date
IE790126L true IE790126L (en) 1979-07-25

Family

ID=4195448

Family Applications (1)

Application Number Title Priority Date Filing Date
IE790126A IE790126L (en) 1978-01-25 1979-01-30 Heterocycle-substituted guanidine derivatives

Country Status (12)

Country Link
JP (1) JPS54112859A (en)
AU (1) AU4359279A (en)
BE (1) BE873658A (en)
DE (1) DE2901362A1 (en)
FR (1) FR2415636A1 (en)
GB (1) GB2013192A (en)
IE (1) IE790126L (en)
IL (1) IL56486A0 (en)
IT (1) IT7947732A0 (en)
NL (1) NL7900444A (en)
SE (1) SE7900459L (en)
ZA (1) ZA79315B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070026811A (en) 2004-06-16 2007-03-08 와이어쓰 Diphenylimidazopyrimidine and -imidazole amines as inhibitors of beta-secretase
EP1756087B1 (en) 2004-06-16 2009-10-07 Wyeth Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
WO2006076284A2 (en) 2005-01-14 2006-07-20 Wyeth AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE
KR20070107062A (en) 2005-02-01 2007-11-06 와이어쓰 AMINO-PYRIDINES AS INHIBITORS OF beta;-SECRETASE
CN101146769A (en) 2005-02-14 2008-03-19 惠氏公司 Azolylacylguanidines as beta-secretase inhibitors
WO2006088694A1 (en) 2005-02-14 2006-08-24 Wyeth SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS
AU2006266167A1 (en) 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200738683A (en) 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
JP2009509957A (en) 2005-09-26 2009-03-12 ワイス Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as β-secretase inhibitors
WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
CL2008000791A1 (en) 2007-03-23 2008-05-30 Wyeth Corp COMPOUNDS DERIVED FROM 2-AMINO-5- (4-DIFLUOROMETOXI-FENIL) -5-FENIL-IMIDAZOLIDIN-4-ONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH EXCESSIVE BACE ACTIVITY, SUCH AS ILLNESS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298112A (en) * 1969-02-20 1972-11-29 Wander Ag Dr A Phenyl acetyl guanidine derivatives

Also Published As

Publication number Publication date
GB2013192A (en) 1979-08-08
NL7900444A (en) 1979-07-27
JPS54112859A (en) 1979-09-04
FR2415636A1 (en) 1979-08-24
BE873658A (en) 1979-07-23
AU4359279A (en) 1979-08-02
SE7900459L (en) 1979-07-26
ZA79315B (en) 1980-09-24
IT7947732A0 (en) 1979-01-23
IL56486A0 (en) 1979-03-12
DE2901362A1 (en) 1979-07-26

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