IE45686L - 7-acylamino - 3 - (sulfomethylheterocyclic - thiomethyl)- 3¹- cephem -4- carboxylic acids. - Google Patents

7-acylamino - 3 - (sulfomethylheterocyclic - thiomethyl)- 3¹- cephem -4- carboxylic acids.

Info

Publication number
IE45686L
IE45686L IE771912A IE191277A IE45686L IE 45686 L IE45686 L IE 45686L IE 771912 A IE771912 A IE 771912A IE 191277 A IE191277 A IE 191277A IE 45686 L IE45686 L IE 45686L
Authority
IE
Ireland
Prior art keywords
acylamino
cephem
carboxylic acids
sulfomethylheterocyclic
thiomethyl
Prior art date
Application number
IE771912A
Other versions
IE45686B1 (en
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/726,378 external-priority patent/US4079134A/en
Priority claimed from US05/726,377 external-priority patent/US4083975A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IE45686L publication Critical patent/IE45686L/en
Publication of IE45686B1 publication Critical patent/IE45686B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel 7-acylamino-3-(sulphomethylthiadiazolylthiomethyl)- or -(sulphomethyltriazolylthiomethyl)-3-cephem-4-carboxylic acids exhibit antibacterial activity against gram-positive and gram-negative bacteria. They are prepared by reacting a corresponding 7-amino- or 7-acylamino-3-acetoxymethyl-cephalosporanic acid with a corresponding sulphomethylthiadiazole-thiol or sulphomethyltriazole-thiol. If a 7-amino-3-acetoxymethyl-cephalosporanic acid is employed, the product is subsequently N-acylated. [GB1591990A]
IE1912/77A 1976-09-24 1977-09-19 7-acylamino-3-(sulfomethylheterocyclicthiomethyl)-3-cephem-4-carboxylic acids IE45686B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/726,378 US4079134A (en) 1976-09-24 1976-09-24 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acids
US05/726,377 US4083975A (en) 1976-09-24 1976-09-24 7-Acylamino-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Publications (2)

Publication Number Publication Date
IE45686L true IE45686L (en) 1978-03-24
IE45686B1 IE45686B1 (en) 1982-10-20

Family

ID=27111308

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1912/77A IE45686B1 (en) 1976-09-24 1977-09-19 7-acylamino-3-(sulfomethylheterocyclicthiomethyl)-3-cephem-4-carboxylic acids

Country Status (9)

Country Link
JP (1) JPS5340796A (en)
CH (1) CH633557A5 (en)
DE (1) DE2742726A1 (en)
DK (1) DK417777A (en)
FR (2) FR2365571A1 (en)
GB (1) GB1591990A (en)
IE (1) IE45686B1 (en)
LU (1) LU78164A1 (en)
NL (1) NL7710439A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6140291A (en) * 1984-07-31 1986-02-26 Shionogi & Co Ltd Hydroxyalkylthiocephalosporin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1201621A (en) * 1967-05-18 1970-08-12 Agfa Gevaert Nv Process for stabilizing developed photographic images

Also Published As

Publication number Publication date
NL7710439A (en) 1978-03-29
CH633557A5 (en) 1982-12-15
DK417777A (en) 1978-03-25
FR2365571A1 (en) 1978-04-21
GB1591990A (en) 1981-07-01
FR2365571B1 (en) 1983-02-25
LU78164A1 (en) 1978-01-24
DE2742726A1 (en) 1978-03-30
FR2392014A1 (en) 1978-12-22
IE45686B1 (en) 1982-10-20
JPS6156237B2 (en) 1986-12-01
JPS5340796A (en) 1978-04-13

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