IE43821L - Prostaglandins - Google Patents
ProstaglandinsInfo
- Publication number
- IE43821L IE43821L IE760120A IE12076A IE43821L IE 43821 L IE43821 L IE 43821L IE 760120 A IE760120 A IE 760120A IE 12076 A IE12076 A IE 12076A IE 43821 L IE43821 L IE 43821L
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- hydrogen
- symbol
- carbon atoms
- alkyl
- Prior art date
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000001262 anti-secretory effect Effects 0.000 abstract 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 abstract 1
- 230000003182 bronchodilatating effect Effects 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003529 luteolytic effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel prostaglandin analogues of the general formula: (I) wherein the ring P represents one of the groups: (a) (b) (c) the symbol A represents -CH2-CH2 - or cis-CH=CH-; the symbol B represents-CH2 -CH2 - or trans-CH=CH-; R is hydrogen, alkyl of 1 to 6 carbon atoms, or a cation; R1 is alkyl of 1 to 6 carbon atoms, R2 represents a straight chain alkyl radical selected from methyl, ethyl, propyl, butyl, pentyl and hexyl; R3 is hydrogen or methyl; R4 is hydrogen or methyl; and R5 is hydroxy or R4 and R5 taken together represent an oxo group are disclosed, together with processes for their preparation. The new compounds have luteolytic, antihypertensive, bronchodilating and anti secretory activity.
[CA1076569A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3248/75A GB1538871A (en) | 1975-01-24 | 1975-01-24 | Prostaglandins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43821L true IE43821L (en) | 1976-07-24 |
| IE43821B1 IE43821B1 (en) | 1981-06-03 |
Family
ID=9754749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE120/76A IE43821B1 (en) | 1975-01-24 | 1976-01-22 | Prostaglandins |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6024098B2 (en) |
| AR (1) | AR212328A1 (en) |
| AT (1) | AT351186B (en) |
| BE (1) | BE837865A (en) |
| CA (1) | CA1076569A (en) |
| CH (1) | CH609682A5 (en) |
| CS (1) | CS187333B2 (en) |
| DD (1) | DD122517A5 (en) |
| DE (1) | DE2601646A1 (en) |
| DK (1) | DK27376A (en) |
| FI (1) | FI64578C (en) |
| FR (1) | FR2298322A1 (en) |
| GB (1) | GB1538871A (en) |
| GR (1) | GR58537B (en) |
| HU (1) | HU174185B (en) |
| IE (1) | IE43821B1 (en) |
| IL (1) | IL48870A (en) |
| LU (1) | LU74240A1 (en) |
| NL (1) | NL185203C (en) |
| NO (1) | NO147714C (en) |
| NZ (1) | NZ179816A (en) |
| PH (1) | PH14040A (en) |
| PT (1) | PT64737B (en) |
| RO (1) | RO71901A (en) |
| SE (1) | SE446726B (en) |
| SU (1) | SU607550A3 (en) |
| YU (1) | YU40805B (en) |
| ZA (1) | ZA7681B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4064350A (en) * | 1976-11-22 | 1977-12-20 | G. D. Searle & Co. | 15,16-Dihydroxyprostaglandins |
| US4194055A (en) * | 1976-03-03 | 1980-03-18 | American Cyanamid Company | 15,16-dioxy prostenoic acids and esters |
| IT1162731B (en) * | 1979-04-10 | 1987-04-01 | Lepetit Spa | 16-METHYL-16-METHOXY-5,6-DIHYDRO-PROSTA-GLANDINE OF THE E1 SERIES WITH ANTI-SECRETORY ACTIVITY |
| JPS56162014A (en) * | 1980-05-16 | 1981-12-12 | Nippon Denso Co Ltd | Measuring device for flow rate of gas |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1392716A (en) * | 1971-05-11 | 1975-04-30 | Ici Ltd | Moulding |
| US4304907A (en) * | 1972-05-10 | 1981-12-08 | The Upjohn Company | Bicyclo lactone intermediates for prostaglandin analogs |
-
1975
- 1975-01-24 GB GB3248/75A patent/GB1538871A/en not_active Expired
-
1976
- 1976-01-05 FI FI760002A patent/FI64578C/en not_active IP Right Cessation
- 1976-01-07 ZA ZA00760081A patent/ZA7681B/en unknown
- 1976-01-09 GR GR49742A patent/GR58537B/en unknown
- 1976-01-15 YU YU111/76A patent/YU40805B/en unknown
- 1976-01-16 CS CS76305A patent/CS187333B2/en unknown
- 1976-01-17 DE DE19762601646 patent/DE2601646A1/en active Granted
- 1976-01-19 IL IL48870A patent/IL48870A/en unknown
- 1976-01-21 RO RO7684563A patent/RO71901A/en unknown
- 1976-01-21 AT AT36776A patent/AT351186B/en not_active IP Right Cessation
- 1976-01-22 FR FR7601707A patent/FR2298322A1/en active Granted
- 1976-01-22 IE IE120/76A patent/IE43821B1/en unknown
- 1976-01-22 PH PH18006A patent/PH14040A/en unknown
- 1976-01-22 DD DD190915A patent/DD122517A5/xx unknown
- 1976-01-23 CH CH83176A patent/CH609682A5/en not_active IP Right Cessation
- 1976-01-23 JP JP51006567A patent/JPS6024098B2/en not_active Expired
- 1976-01-23 AR AR262009A patent/AR212328A1/en active
- 1976-01-23 BE BE163765A patent/BE837865A/en not_active IP Right Cessation
- 1976-01-23 PT PT64737A patent/PT64737B/en unknown
- 1976-01-23 CA CA244,132A patent/CA1076569A/en not_active Expired
- 1976-01-23 SU SU762311606A patent/SU607550A3/en active
- 1976-01-23 HU HU76LE788A patent/HU174185B/en not_active IP Right Cessation
- 1976-01-23 LU LU74240A patent/LU74240A1/xx unknown
- 1976-01-23 DK DK27376*#A patent/DK27376A/en not_active Application Discontinuation
- 1976-01-23 NO NO760214A patent/NO147714C/en unknown
- 1976-01-23 NZ NZ179816A patent/NZ179816A/en unknown
- 1976-01-23 NL NLAANVRAGE7600696,A patent/NL185203C/en not_active IP Right Cessation
- 1976-01-23 SE SE7600729A patent/SE446726B/en not_active IP Right Cessation
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