IE42290L - 4-aminoquinoline derivatives - Google Patents

4-aminoquinoline derivatives

Info

Publication number
IE42290L
IE42290L IE752810A IE281075A IE42290L IE 42290 L IE42290 L IE 42290L IE 752810 A IE752810 A IE 752810A IE 281075 A IE281075 A IE 281075A IE 42290 L IE42290 L IE 42290L
Authority
IE
Ireland
Prior art keywords
rnh
compounds
jan
halogen
substituted
Prior art date
Application number
IE752810A
Other versions
IE42290B1 (en
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of IE42290L publication Critical patent/IE42290L/en
Publication of IE42290B1 publication Critical patent/IE42290B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1474296 4-Aminoquinoline derivatives JOHN WYETH & BRO Ltd 23 Jan 1976 [23 Jan 1975] 2924/75 Addition to 1416872 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein X is halogen or CF 3 ; Z is H, halogen, CF 3 , OH, NO 2 , R, RO, RNH or (R) 2 N, where R is C 1-6 alkyl; R<SP>1</SP> is H or R; and R<SP>2</SP> is RNH-A or (R) 2 N-A (A being C 1-6 alkylene), or piperidyl (optionally 1-substituted by aryl-A- or R); or NR<SP>1</SP>R<SP>2</SP> is RNH- or (R) 2 N- substituted piperidine. In examples, these compounds are prepared by reacting the corresponding acid chloride with HNH<SP>1</SP>R<SP>2</SP>. Therapeutic compositions having antiinflammatory activity, and in certain eases antihypertensive or blood platelet aggregation inhibiting activity, comprise compounds of the above formula, and may be administered (e.g.) orally or parenterally. [GB1474296A]
IE2810/75A 1975-01-23 1975-12-23 4-aminoquinoline derivatives IE42290B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB292475A GB1474296A (en) 1975-01-23 1975-01-23 4-aminoquinoline derivatives

Publications (2)

Publication Number Publication Date
IE42290L true IE42290L (en) 1976-07-23
IE42290B1 IE42290B1 (en) 1980-07-16

Family

ID=9748630

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2810/75A IE42290B1 (en) 1975-01-23 1975-12-23 4-aminoquinoline derivatives

Country Status (8)

Country Link
JP (1) JPS6015620B2 (en)
BE (1) BE837698A (en)
CA (1) CA1067080A (en)
CH (2) CH586682A5 (en)
DE (1) DE2559104A1 (en)
FR (1) FR2298330A2 (en)
GB (1) GB1474296A (en)
IE (1) IE42290B1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573186A (en) * 1977-09-14 1980-08-20 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
SE448091B (en) * 1977-12-15 1987-01-19 Roussel Uclaf NEW 2 - / (4-QUINOLINYL) -AMINO / -5-FLUOROBENOIC ACID DERIVATIVES, PROCEDURES FOR PREPARING IT, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES
PH22302A (en) * 1985-02-11 1988-07-22 Fujisawa Pharmaceutical Co Piperidine compounds
PL310889A1 (en) * 1993-03-29 1996-01-08 Zeneca Ltd Heterocyclic derivatives as inhibitors of thrombocytes aggregation
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1416872A (en) * 1972-03-10 1975-12-10 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
CH585221A5 (en) * 1972-07-28 1977-02-28 Synthelabo

Also Published As

Publication number Publication date
GB1474296A (en) 1977-05-18
FR2298330A2 (en) 1976-08-20
JPS5195080A (en) 1976-08-20
CH586681A5 (en) 1977-04-15
IE42290B1 (en) 1980-07-16
FR2298330B2 (en) 1982-08-27
BE837698A (en) 1976-07-19
DE2559104A1 (en) 1976-07-29
CA1067080A (en) 1979-11-27
CH586682A5 (en) 1977-04-15
JPS6015620B2 (en) 1985-04-20

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