IE40430L - Hypolipidemic alkenesulphonamides - Google Patents

Hypolipidemic alkenesulphonamides

Info

Publication number
IE40430L
IE40430L IE742515A IE251574A IE40430L IE 40430 L IE40430 L IE 40430L IE 742515 A IE742515 A IE 742515A IE 251574 A IE251574 A IE 251574A IE 40430 L IE40430 L IE 40430L
Authority
IE
Ireland
Prior art keywords
group
carbon atoms
alkyl group
alkyl
phenyl
Prior art date
Application number
IE742515A
Other versions
IE40430B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE40430L publication Critical patent/IE40430L/en
Publication of IE40430B1 publication Critical patent/IE40430B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1473200 Phenylalkenesulphonylureas PFIZER Inc 5 Dec 1974 [5 Dec 1973] 52751/74 Heading C2C The invention comprises novel compounds (I) and (II) and the salts thereof, wherein X is a hydrogen, fluorine, chlorine or bromine atom, a trifluoromethyl group, an alkyl group having one to four carbon atoms or an alkoxy group having from one to four carbon atoms, each of A and B, which may be the same or different, is a hydrogen atom or a methyl, ethyl or phenyl group, Z is a pyrrolidino, morpholino, thiomorpholino, 1,2,5,6-tetrahydropyridino, 1,2,3,4-tetrahydroisoquinolino, azacycloheptan - 1 - yl, azacyclooctan - 1 - yl, 3 - azabicyclo[3.2.2]nonan- 3 - yl, piperidino, 4 - hydroxypiperidino, 4- methoxypiperidino, 4-carboxypiperidino, 4-phenylpiperidino, alkylpiperidino having one to three carbon atoms in the alkyl group, (phenylalkyl) piperidino, having from one to five carbon atoms in the alkyl group, homopiperidino or ([substituted phenyl]alkyl)piperidino group having from one to five carbon atoms in the alkyl group, the said substituted phenyl group being substituted by a hydroxy group, an alkyl group having from one to four carbon atoms or an akoxy group having from one to four carbon atoms, and each of R<SP>1</SP> and R<SP>2</SP>, which may be the same or different, is a hydrogen atom or an alkyl group having from one to ten carbon atoms, an alkenyl group having from three to six carbon atoms, a cycloalkyl group having from three to seven carbon atoms, a phenylalkyl group having one or two carbon atoms in the alkyl group, a carboxyalkyl group having from one to seven carbon atoms in the alkyl group, an alkoxycarbonylalkyl group having one or two carbon atoms in the alkoxy group and having from one to seven carbon atoms in the alkyl group, or a bicyclo[2.2.1]hept-2-en-5-ylmethyl, 7-oxabicyclo[2.2.1]heptan-2-ylmethyl, bicyclo[2.2.1]heptan- 2 - ylmethyl, or phenyl group, or a phenyl group substituted by a fluorine, chlorine or bromine atom, or a nitro group, an alkyl group having from one to four carbon atoms or an alkoxy group having from one to four carbon atoms, provided that when both A and B are hydrogen atoms and either R<SP>1</SP> or R<SP>2</SP> is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, phenyl or substituted phenyl group the other R<SP>1</SP> or R<SP>2</SP> is other than a hydrogen atom or an alkyl group. They are made by standard methods. Pharmaceutical preparations having hypolipidemic action contain (I) and/or (II) (the provisos not applying) as active ingredient. Administration is orally or parenterally. [GB1473200A]
IE2515/74A 1973-12-05 1974-12-05 Hypolipidemic alkenesulphonamides IE40430B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42208873A 1973-12-05 1973-12-05

Publications (2)

Publication Number Publication Date
IE40430L true IE40430L (en) 1975-06-05
IE40430B1 IE40430B1 (en) 1979-05-23

Family

ID=23673328

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2515/74A IE40430B1 (en) 1973-12-05 1974-12-05 Hypolipidemic alkenesulphonamides

Country Status (18)

Country Link
JP (1) JPS50111046A (en)
AR (2) AR208187A1 (en)
AU (1) AU7575774A (en)
BE (1) BE822874A (en)
CA (1) CA1042909A (en)
DD (1) DD115491A5 (en)
DE (1) DE2456947A1 (en)
DK (1) DK144270C (en)
ES (1) ES432573A1 (en)
FI (1) FI351574A (en)
FR (1) FR2253513B1 (en)
GB (1) GB1473200A (en)
IE (1) IE40430B1 (en)
IL (1) IL46116A0 (en)
LU (1) LU71425A1 (en)
NL (1) NL7415796A (en)
NO (1) NO744383L (en)
ZA (1) ZA747728B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330603A1 (en) * 1983-08-25 1985-03-21 Hoechst Ag, 6230 Frankfurt NEW 2-AMINO-ALKENYL-SULFONYL-UREAS
US5216026A (en) * 1990-07-17 1993-06-01 Eli Lilly And Company Antitumor compositions and methods of treatment
JP4634694B2 (en) 2001-03-23 2011-02-16 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド Fatty alcohol drug complex
WO2002076402A2 (en) * 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
WO2019043610A1 (en) * 2017-08-31 2019-03-07 Cadila Healthcare Limited Novel substituted sulfonylurea derivatives
JP7488267B2 (en) * 2019-01-14 2024-05-21 ザイダス・ライフサイエンシーズ・リミテッド Novel substituted sulfonylurea derivatives

Also Published As

Publication number Publication date
BE822874A (en) 1975-06-03
JPS50111046A (en) 1975-09-01
GB1473200A (en) 1977-05-11
DD115491A5 (en) 1975-10-05
DK629974A (en) 1975-07-21
NL7415796A (en) 1975-06-09
FI351574A (en) 1975-06-06
FR2253513A1 (en) 1975-07-04
NO744383L (en) 1975-06-30
IE40430B1 (en) 1979-05-23
CA1042909A (en) 1978-11-21
AR211918A1 (en) 1978-04-14
ES432573A1 (en) 1976-11-01
LU71425A1 (en) 1975-08-20
DE2456947A1 (en) 1975-06-12
DK144270C (en) 1982-07-12
AR208187A1 (en) 1976-12-09
DK144270B (en) 1982-02-01
IL46116A0 (en) 1975-02-10
FR2253513B1 (en) 1978-07-28
ZA747728B (en) 1976-02-25
AU7575774A (en) 1976-05-27

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