IE40329L - Tetrahydroquinoline derivatives. - Google Patents

Tetrahydroquinoline derivatives.

Info

Publication number
IE40329L
IE40329L IE742561A IE256174A IE40329L IE 40329 L IE40329 L IE 40329L IE 742561 A IE742561 A IE 742561A IE 256174 A IE256174 A IE 256174A IE 40329 L IE40329 L IE 40329L
Authority
IE
Ireland
Prior art keywords
dimethoxyanilino
formula
oxotetrahydroquinoline
prepared
compound
Prior art date
Application number
IE742561A
Other versions
IE40329B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE40329L publication Critical patent/IE40329L/en
Publication of IE40329B1 publication Critical patent/IE40329B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1454039 Substituted 4-oxotetrahydroquinoline 1-carboxylates PFIZER Inc 13 Sept 1974 [26 Dec 1973] 40126/74 Heading C2C The invention comprises compounds of Formula I wherein R, R 1 and R 2 are the same or different and are C 1-4 alkyl groups which may be prepared by acylation of a compound of Formula II with an appropriate agent, e.g. alkylchloroformate. Ethyl - 3 - [3,4 - dimethoxyanilino] - 2 - butenoate is prepared by reaction of 4-animoveratrole with ethylacetoacetate and is hydrogenated to obtain ethyl - 3 - [3,4 - dimethoxyanilino]- butanoate which on treatment under reflux with methanolic aqueous sodium hydroxide is hydrolysed to 3-[3,4-dimethoxyanilino]butanoic acid which is cyclized by heating with polyphosphoric acid to obtain 6,7-dimethyoxy-2-methyl- 4-oxotetrahydroquinoline. Pharmaceutical compositions having analgesic and tranquillizing activity for oral or parenteral application comprise a compound of Formula I together with a pharmaceutically acceptable carrier. [GB1454039A]
IE2561/74A 1973-12-26 1974-12-12 Alkyl 6,7-dialkoyz-2-methyl-4-oxo-1-carboxylates IE40329B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42844173A 1973-12-26 1973-12-26

Publications (2)

Publication Number Publication Date
IE40329L true IE40329L (en) 1975-06-26
IE40329B1 IE40329B1 (en) 1979-05-09

Family

ID=23698907

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2561/74A IE40329B1 (en) 1973-12-26 1974-12-12 Alkyl 6,7-dialkoyz-2-methyl-4-oxo-1-carboxylates

Country Status (21)

Country Link
JP (1) JPS582937B2 (en)
AR (1) AR205807A1 (en)
BE (1) BE823811A (en)
CA (1) CA1035360A (en)
DD (1) DD117454A5 (en)
DE (1) DE2461050C2 (en)
DK (1) DK138889B (en)
ES (1) ES433305A1 (en)
FI (1) FI368374A (en)
FR (1) FR2255906B1 (en)
GB (1) GB1454039A (en)
HU (1) HU169380B (en)
IE (1) IE40329B1 (en)
IL (1) IL46232A0 (en)
LU (1) LU71558A1 (en)
NL (1) NL7416666A (en)
NO (1) NO744670L (en)
RO (1) RO64270A (en)
SE (1) SE421417B (en)
SU (1) SU538663A3 (en)
ZA (1) ZA748171B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978064A (en) * 1975-11-04 1976-08-31 Pfizer Inc. 3-Aminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid esters and intermediates leading thereto

Also Published As

Publication number Publication date
DE2461050A1 (en) 1975-07-17
ZA748171B (en) 1976-01-28
AR205807A1 (en) 1976-06-07
NO744670L (en) 1975-07-21
DK138889B (en) 1978-11-13
GB1454039A (en) 1976-10-27
DE2461050C2 (en) 1983-12-29
DD117454A5 (en) 1976-01-12
FR2255906B1 (en) 1978-06-30
FI368374A (en) 1975-06-27
LU71558A1 (en) 1975-08-20
NL7416666A (en) 1975-06-30
CA1035360A (en) 1978-07-25
SE7415497L (en) 1975-06-27
DK138889C (en) 1979-04-30
JPS582937B2 (en) 1983-01-19
DK653874A (en) 1975-08-25
SU538663A3 (en) 1976-12-05
ES433305A1 (en) 1977-03-01
IL46232A0 (en) 1975-03-13
AU7658174A (en) 1976-06-24
JPS50105672A (en) 1975-08-20
RO64270A (en) 1979-05-15
FR2255906A1 (en) 1975-07-25
IE40329B1 (en) 1979-05-09
HU169380B (en) 1976-11-28
SE421417B (en) 1981-12-21
BE823811A (en) 1975-06-24

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