IE37741B1 - Cell vaccine production - Google Patents
Cell vaccine productionInfo
- Publication number
- IE37741B1 IE37741B1 IE89873A IE89873A IE37741B1 IE 37741 B1 IE37741 B1 IE 37741B1 IE 89873 A IE89873 A IE 89873A IE 89873 A IE89873 A IE 89873A IE 37741 B1 IE37741 B1 IE 37741B1
- Authority
- IE
- Ireland
- Prior art keywords
- plates
- cells
- tank
- inches
- june
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18461—Methods of inactivation or attenuation
- C12N2760/18464—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
1393654 Making viral vaccines MERCK & CO INC 11 June 1973 [14 June 1972] 27636/73 Heading A5B [Also in Divisions Bl and C6] In a process for the production of cells and/ or vaccines cells are grown and/or infected with virus in a rotary multiplate propagator which comprises a cylindrical tank 2 and a plurality of plates 19 mounted normally to the axis of the cylindrical tank and rotatable thereabout, the plate and tank diameters being in the ratio 0.8:1 to 0.9:1. Preferably the surface area to volume ratio of the apparatus lies between 5.5:1 and 6.0:1. The tank may be of stainless steel, and the plates of titanium, and typical diameters are 7“ inches and 6 inches or 6 inches and 5.4 inches respectively. Drive to the shaft 20 on which the plates are mounted includes a magnetic coupling 25, 26 and the tank is provided with inlet and outlet connections for supply and egress of air or air/CO 2 mixture, culture medium and product or spent liquor. Coating of the plates with cells is effected with the apparatus placed with its axis vertical and the apparatus may be inverted to ensure coating of both sides of the plates. Cell growth or infection of cells grown on the plates is carried out with the apparatus horizontal, about half full of liquid medium and with the plates rotating e.g. at about 1/5 r.p.m. Reference is made and examples given relating to production of viral vaccines such as mumps, measles, rubella, Marek's, influenza, parainfluenza, varicella, trachoma, and respiratory syncytia and cells such as WI-38, chick embryo and duck embryo cells.
[GB1393654A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26282572A | 1972-06-14 | 1972-06-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE37741L IE37741L (en) | 1973-12-14 |
IE37741B1 true IE37741B1 (en) | 1977-09-28 |
Family
ID=22999223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE89873A IE37741B1 (en) | 1972-06-14 | 1973-06-06 | Cell vaccine production |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS4955524A (en) |
BR (1) | BR7304428D0 (en) |
ES (1) | ES415570A1 (en) |
GB (1) | GB1393654A (en) |
IE (1) | IE37741B1 (en) |
NL (1) | NL7307143A (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2624047C3 (en) * | 1976-05-28 | 1980-07-03 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Mass culture of cells and chamber system to carry them out |
AU6156780A (en) * | 1979-08-24 | 1981-04-09 | G.D. Searle & Co. | Stack plate culture |
US8206973B2 (en) | 2003-09-04 | 2012-06-26 | Gotohti.Com Inc | Automated biological growth and dispensing system |
CA2439645C (en) * | 2003-09-04 | 2014-03-18 | Hygiene-Technik Inc. | Automated biological growth and dispensing system |
DE102010005415B4 (en) * | 2010-01-22 | 2015-07-16 | Zellwerk Gmbh | Method and device for the dynamic expansion and / or differentiation of suspended primary cells or stem cells of human and animal origin |
SG11201807903TA (en) | 2016-03-14 | 2018-10-30 | Ravindrakumar Dhirubhai Patel | A bioreactor system and method thereof |
-
1973
- 1973-05-22 NL NL7307143A patent/NL7307143A/xx not_active Application Discontinuation
- 1973-06-05 ES ES415570A patent/ES415570A1/en not_active Expired
- 1973-06-06 IE IE89873A patent/IE37741B1/en unknown
- 1973-06-11 GB GB2763673A patent/GB1393654A/en not_active Expired
- 1973-06-13 BR BR442873A patent/BR7304428D0/en unknown
- 1973-06-14 JP JP6645573A patent/JPS4955524A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR7304428D0 (en) | 1974-08-15 |
GB1393654A (en) | 1975-05-07 |
NL7307143A (en) | 1973-12-18 |
JPS4955524A (en) | 1974-05-29 |
ES415570A1 (en) | 1976-06-16 |
IE37741L (en) | 1973-12-14 |
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