IE37596L - 21-substituted 3ó-hydroxy pregnanes. - Google Patents

21-substituted 3ó-hydroxy pregnanes.

Info

Publication number
IE37596L
IE37596L IE730709A IE70973A IE37596L IE 37596 L IE37596 L IE 37596L IE 730709 A IE730709 A IE 730709A IE 70973 A IE70973 A IE 70973A IE 37596 L IE37596 L IE 37596L
Authority
IE
Ireland
Prior art keywords
alpha
substituted
hydroxy
additionally
pregnanes
Prior art date
Application number
IE730709A
Other versions
IE37596B1 (en
Original Assignee
Glaxo Labotatories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Labotatories Ltd filed Critical Glaxo Labotatories Ltd
Publication of IE37596L publication Critical patent/IE37596L/en
Publication of IE37596B1 publication Critical patent/IE37596B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)

Abstract

3 alpha -Hydroxy-5 alpha ,ss-pregnan- and -19-norpregnan-20-ones which have in position 21 a substituent selected from cyano, azido and cycloamino and which can additionally be substituted in position 11 by another oxo group and can have in positions 2 alpha , 2ss, 3ss and 16 other substituents defined in Claims 1, 5 and 8, and which can additionally contain a double bond in the 1,2 and/or 4,5 position, have anaesthetic effects and provide short induction times. They are prepared by reacting a corresponding steroid which has in position 21 an easily eliminated radical with a compound which supplies cyanide or azide ions or with an appropriate cyclic amine. [GB1430942A]
IE709/73A 1972-05-05 1973-05-04 21-substituted 3alpha-hydroxy pregnanes IE37596B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2114272A GB1430942A (en) 1972-05-05 1972-05-05 21-substituted 3alpha-hydroxy pregnanes

Publications (2)

Publication Number Publication Date
IE37596L true IE37596L (en) 1973-11-05
IE37596B1 IE37596B1 (en) 1977-08-31

Family

ID=10157915

Family Applications (1)

Application Number Title Priority Date Filing Date
IE709/73A IE37596B1 (en) 1972-05-05 1973-05-04 21-substituted 3alpha-hydroxy pregnanes

Country Status (16)

Country Link
JP (1) JPS4961150A (en)
AT (1) AT355232B (en)
AU (1) AU475168B2 (en)
BE (1) BE799102A (en)
CA (1) CA1013341A (en)
CH (1) CH617710A5 (en)
DE (1) DE2322532A1 (en)
ES (1) ES414411A1 (en)
FR (1) FR2183792B1 (en)
GB (1) GB1430942A (en)
IE (1) IE37596B1 (en)
IL (1) IL42196A (en)
LU (1) LU67546A1 (en)
NL (1) NL7306234A (en)
SE (1) SE400771B (en)
ZA (1) ZA733035B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
NZ282939A (en) * 1994-02-14 1998-08-26 Cocensys Inc Androstanes and pregnanes for allosteric modulation of gaba receptors
US5939545A (en) * 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
GR1003861B (en) * 2000-12-29 2002-04-11 Novel gabaa modulating neurosteroids
JP4915427B2 (en) * 2009-03-30 2012-04-11 ブラザー工業株式会社 Liquid supply joint, liquid discharge head and recording apparatus using the same
ES2738526T3 (en) 2011-10-14 2020-01-23 Sage Therapeutics Inc Compounds 19-norpregnano 3,3-disubstituted, compositions and uses thereof
WO2013112605A2 (en) 2012-01-23 2013-08-01 Sage Therapeutics, Inc. Neuroactive steroid formulations and methods of treating cns disorders
IL275725B (en) 2012-08-21 2022-08-01 Sage Therapeutics Inc Methods of treating epilepsy or status epilepticus
HRP20200995T1 (en) 2013-04-17 2020-11-27 Sage Therapeutics, Inc. 19-nor neuroactive steroids for methods of treatment
HRP20190232T1 (en) 2013-04-17 2019-03-22 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
SMT202100229T1 (en) 2013-07-19 2021-05-07 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
SMT202100048T1 (en) 2013-08-23 2021-03-15 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (en) 2014-09-08 2017-06-16 Sage Therapeutics Inc Neuroactive steroids and formulations, and their uses
AU2015331749A1 (en) 2014-10-16 2017-05-04 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
JP6742308B2 (en) 2014-10-16 2020-08-19 セージ セラピューティクス， インコーポレイテッド Compositions and methods for treating CNS disorders
ES2793237T3 (en) 2014-11-27 2020-11-13 Sage Therapeutics Inc Compositions and methods for treating CNS disorders
SI3250210T1 (en) 2015-01-26 2021-07-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
US10329320B2 (en) 2015-02-20 2019-06-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
SG11201807785VA (en) 2016-03-08 2018-10-30 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
CN109689673B (en) 2016-07-11 2023-03-14 萨奇治疗股份有限公司 C17, C20 and C21 substituted neuroactive steroids and methods of use thereof
AU2017296295B2 (en) 2016-07-11 2022-02-24 Sage Therapeutics, Inc. C7, C12, and C16 substituted neuroactive steroids and their methods of use
CN114206900A (en) 2019-05-31 2022-03-18 萨奇治疗股份有限公司 Neuroactive steroids and compositions thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1346292A (en) * 1962-09-14 1963-12-20 Roussel Uclaf New process for the preparation of 21-amino steroids
US3144446A (en) * 1963-12-20 1964-08-11 Upjohn Co Mono and bis nu-(3alpha, 17alpha-dihydroxy-11, 20-dioxo-5beta-pregnan-21-yl) quaternary ammonium salts of triethylenediamine

Also Published As

Publication number Publication date
JPS4961150A (en) 1974-06-13
IE37596B1 (en) 1977-08-31
DE2322532A1 (en) 1973-11-22
CA1013341A (en) 1977-07-05
CH617710A5 (en) 1980-06-13
FR2183792A1 (en) 1973-12-21
IL42196A (en) 1978-10-31
GB1430942A (en) 1976-04-07
AU475168B2 (en) 1976-08-12
ES414411A1 (en) 1976-02-01
NL7306234A (en) 1973-11-07
ATA395173A (en) 1979-07-15
LU67546A1 (en) 1973-07-13
ZA733035B (en) 1974-04-24
FR2183792B1 (en) 1977-07-15
AT355232B (en) 1980-02-25
BE799102A (en) 1973-11-05
AU5528473A (en) 1974-11-07
IL42196A0 (en) 1973-07-30
SE400771B (en) 1978-04-10

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