IE36406B1 - Pregna-4,6-dieno-(3,2-c) pyrazoles - Google Patents

Pregna-4,6-dieno-(3,2-c) pyrazoles

Info

Publication number
IE36406B1
IE36406B1 IE78872A IE78872A IE36406B1 IE 36406 B1 IE36406 B1 IE 36406B1 IE 78872 A IE78872 A IE 78872A IE 78872 A IE78872 A IE 78872A IE 36406 B1 IE36406 B1 IE 36406B1
Authority
IE
Ireland
Prior art keywords
pregna
dieno
pyridyl
dimethyl
reacting
Prior art date
Application number
IE78872A
Other versions
IE36406L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE36406L publication Critical patent/IE36406L/en
Publication of IE36406B1 publication Critical patent/IE36406B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

1359108 Pregna-4,6-dieno-[3,2-c]pyrazoles MERCK & CO Inc 24 July 1972 [30 July 1971] 34515/72 Headings C2U and C2C The novel 2<SP>1</SP>-(4-pyridyl)-6,16α-dimethyl-20- oxo - 11#,17α,21 - trihydroxy - pregna - 4,6- dieno[3,2-c]-pyrazole is prepared by reacting 4- hydrazino-pyridine with 2-hydroxymethylene- 6,16α - dimethyl - 11# - hydroxy - 17,20 : 20,21- bismethylenedioxy - pregna - 4,6 - dien - 3 - one to produce the novel 2<SP>1</SP>-(4-pyridyl)-6,16a-dimethyl - 11# - hydroxy - 17,20 : 20,21 - bismethylenedioxy - pregna - 4,6 - dieno[3,2-c]- pyrazole and then reacting this with an acidic hydrolysing agent. 4 - Hydrazino - pyridine hydrochloride is prepared by reacting 4-chloropyridine with benzoyl hydrazine to give an N-(4-pyridyl)benzhydrazide of m.p. 225-231‹ C. and then hydrolysing this with hydrochloric acid. The novel trihydroxy-steroid is an antiinflammatory agent, and it may be made up into pharmaceutical compositions with suitable carriers. [GB1359108A]
IE78872A 1971-07-30 1972-06-07 Pregna-4,6-dieno-(3,2-c) pyrazoles IE36406B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16780271A 1971-07-30 1971-07-30

Publications (2)

Publication Number Publication Date
IE36406L IE36406L (en) 1973-01-30
IE36406B1 true IE36406B1 (en) 1976-10-27

Family

ID=22608892

Family Applications (1)

Application Number Title Priority Date Filing Date
IE78872A IE36406B1 (en) 1971-07-30 1972-06-07 Pregna-4,6-dieno-(3,2-c) pyrazoles

Country Status (8)

Country Link
JP (1) JPS544957B1 (en)
AU (1) AU462875B2 (en)
BE (1) BE786884A (en)
CH (1) CH581669A5 (en)
FR (1) FR2148037B1 (en)
GB (1) GB1359108A (en)
IE (1) IE36406B1 (en)
ZA (1) ZA723885B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7307072A (en) * 1972-06-09 1973-12-11

Also Published As

Publication number Publication date
FR2148037A1 (en) 1973-03-11
JPS544957B1 (en) 1979-03-12
AU462875B2 (en) 1975-06-24
CH581669A5 (en) 1976-11-15
FR2148037B1 (en) 1975-08-08
GB1359108A (en) 1974-07-10
IE36406L (en) 1973-01-30
DE2237218B2 (en) 1977-01-20
BE786884A (en) 1973-01-29
DE2237218A1 (en) 1973-02-08
AU4329872A (en) 1973-12-13
ZA723885B (en) 1974-01-30

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