IE35780L - Hydroxocobalamin-amino acid derivative - Google Patents
Hydroxocobalamin-amino acid derivativeInfo
- Publication number
- IE35780L IE35780L IE136971A IE136971A IE35780L IE 35780 L IE35780 L IE 35780L IE 136971 A IE136971 A IE 136971A IE 136971 A IE136971 A IE 136971A IE 35780 L IE35780 L IE 35780L
- Authority
- IE
- Ireland
- Prior art keywords
- hydroxocobalamin
- amino acid
- derivative
- oct
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
- C09B43/32—Preparation of azo dyes from other azo compounds by reacting carboxylic or sulfonic groups, or derivatives thereof, with amines; by reacting keto-groups with amines
- C09B43/38—Preparation of azo dyes from other azo compounds by reacting carboxylic or sulfonic groups, or derivatives thereof, with amines; by reacting keto-groups with amines by reacting two or more ortho-hydroxy naphthoic acid dyes with polyamines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1345327 Hydroxocobalamin derivatives J BOIGE 28 Oct 1971 [28 Oct 1970 13 May 1971] 51242/70 and 14784/71 Heading C2V A derivative of hydroxocobalamin comprises a complex in which the hydroxyl group of the hydroxocobalamin is blocked by the amino group of an amino acid of formula where n is 1 or 2 and when n is 1 then R is hydrogen, methyl, and when n is 2 then R is hydrogen. The derivative is prepared by reacting the hydroxocobalamin with the amino acid in aqueous solution at ambient temperature, the pH being maintained at between 6À2 and 8À6. When the reaction is complete, crystallization is induced by adding a water-miscible organic liquid which does not dissolve hydroxocobalamin, e.g. acetone. The amino acid may be glycine, alphaalanine, beta-alanine, aspartic acid or glutamic acid. Examples are given. A pharmaceutical composition comprises the above-described derivative together with suitable diluents or carriers. (From GB1345327 A) [FR2111895A1]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5124270 | 1970-10-28 | ||
GB1478471 | 1971-05-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE35780L true IE35780L (en) | 1972-04-28 |
IE35780B1 IE35780B1 (en) | 1976-05-26 |
Family
ID=26250793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1369/71A IE35780B1 (en) | 1970-10-28 | 1971-10-28 | Hydroxocobalamin derivatives |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE774108A (en) |
CH (1) | CH535248A (en) |
ES (1) | ES396350A1 (en) |
FR (1) | FR2111895B1 (en) |
GB (1) | GB1345327A (en) |
IE (1) | IE35780B1 (en) |
LU (1) | LU64101A1 (en) |
NL (1) | NL7114810A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
US5807832A (en) * | 1987-06-09 | 1998-09-15 | Biotech Australia Pty Limited | Oral delivery of biologically active substances bound to vitamin B12 |
EP0531497B1 (en) * | 1991-04-02 | 1997-08-13 | Biotech Australia Pty. Limited | Oral delivery systems for microparticles |
CA2266412A1 (en) * | 1996-09-18 | 1998-03-26 | William J. Sarill | Compositions containing cobalamin and amino acids |
-
1971
- 1971-10-18 LU LU64101A patent/LU64101A1/xx unknown
- 1971-10-18 BE BE774108A patent/BE774108A/en unknown
- 1971-10-25 ES ES396350A patent/ES396350A1/en not_active Expired
- 1971-10-27 FR FR7138657A patent/FR2111895B1/fr not_active Expired
- 1971-10-27 CH CH1566771A patent/CH535248A/en not_active IP Right Cessation
- 1971-10-27 NL NL7114810A patent/NL7114810A/xx unknown
- 1971-10-28 GB GB5124270A patent/GB1345327A/en not_active Expired
- 1971-10-28 IE IE1369/71A patent/IE35780B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
LU64101A1 (en) | 1973-05-03 |
BE774108A (en) | 1972-04-18 |
FR2111895A1 (en) | 1972-06-09 |
CH535248A (en) | 1973-03-31 |
NL7114810A (en) | 1972-05-03 |
IE35780B1 (en) | 1976-05-26 |
FR2111895B1 (en) | 1975-10-10 |
ES396350A1 (en) | 1974-05-01 |
GB1345327A (en) | 1974-01-30 |
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