IE35777B1 - Improvements in or relating to the preparation of azetidin-2-one derivatives - Google Patents

Improvements in or relating to the preparation of azetidin-2-one derivatives

Info

Publication number
IE35777B1
IE35777B1 IE136071A IE136071A IE35777B1 IE 35777 B1 IE35777 B1 IE 35777B1 IE 136071 A IE136071 A IE 136071A IE 136071 A IE136071 A IE 136071A IE 35777 B1 IE35777 B1 IE 35777B1
Authority
IE
Ireland
Prior art keywords
radical
azetidin
relating
derivatives
preparation
Prior art date
Application number
IE136071A
Other versions
IE35777L (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2888571A external-priority patent/GB1355330A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE35777L publication Critical patent/IE35777L/en
Publication of IE35777B1 publication Critical patent/IE35777B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Process for eliminating a radical of formula -CR=CMe2 (R = acyl or a carboxylic acid radical opt. in the form of an amide, ester or thioester), from an azetidin-2-one carrying the radical on the ring N atom, and replacing it with H, comprises reacting the azetidinone with a reagent capable of oxidising addition to the double bond of the radical (pref. OsO4 or KMnO4). The products are useful in the synthesis of bicyclic cpds. (cf DT-1935970) esp. penam, cepham and cephems, having antibacterial or other pharmacological activity. [FR2114596A5]
IE136071A 1970-11-12 1971-10-27 Improvements in or relating to the preparation of azetidin-2-one derivatives IE35777B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2888571A GB1355330A (en) 1970-11-12 1970-11-12 Preparation of azetidin-2-one derivatives
GB2888571 1971-06-19

Publications (2)

Publication Number Publication Date
IE35777L IE35777L (en) 1972-05-12
IE35777B1 true IE35777B1 (en) 1976-05-26

Family

ID=26259613

Family Applications (1)

Application Number Title Priority Date Filing Date
IE136071A IE35777B1 (en) 1970-11-12 1971-10-27 Improvements in or relating to the preparation of azetidin-2-one derivatives

Country Status (8)

Country Link
BE (1) BE775297A (en)
CA (1) CA946390A (en)
CH (1) CH566980A5 (en)
DE (1) DE2156352A1 (en)
ES (1) ES396816A1 (en)
FR (1) FR2114596A5 (en)
IE (1) IE35777B1 (en)
NL (1) NL7115539A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021676B1 (en) * 1979-06-08 1983-09-14 Takeda Chemical Industries, Ltd. 3-methoxy-2-oxoazetidine derivatives and their production
DE3231060A1 (en) * 1982-08-20 1984-02-23 Bayer Ag, 5090 Leverkusen 7-OXO-4-OXA-DIAZABICYCLO- (3.2.0) -HEPT-2-EN DERIVATIVES UNSUBSTITUTED IN 6-POSITION, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF SS-LACTAANTIBI

Also Published As

Publication number Publication date
CH566980A5 (en) 1975-09-30
NL7115539A (en) 1972-05-16
BE775297A (en) 1972-05-12
ES396816A1 (en) 1974-12-16
FR2114596A5 (en) 1972-06-30
DE2156352A1 (en) 1972-05-18
CA946390A (en) 1974-04-30
IE35777L (en) 1972-05-12

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