IE20100196A1 - A glass ceramical biomaterial - Google Patents

A glass ceramical biomaterial

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Publication number
IE20100196A1
IE20100196A1 IE20100196A IE20100196A IE20100196A1 IE 20100196 A1 IE20100196 A1 IE 20100196A1 IE 20100196 A IE20100196 A IE 20100196A IE 20100196 A IE20100196 A IE 20100196A IE 20100196 A1 IE20100196 A1 IE 20100196A1
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IE
Ireland
Prior art keywords
biomaterial
crystalline
silicate
strontium
molar percentage
Prior art date
Application number
IE20100196A
Inventor
Daniel Boyd
Mark Looney
Original Assignee
Cork Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cork Inst Technology filed Critical Cork Inst Technology
Priority to IE20100196A priority Critical patent/IE20100196A1/en
Priority to PCT/EP2011/055039 priority patent/WO2011121087A1/en
Publication of IE20100196A1 publication Critical patent/IE20100196A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C10/00—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
    • C03C10/0009—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition containing silica as main constituent
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/062—Glass compositions containing silica with less than 40% silica by weight
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C03C3/078—Glass compositions containing silica with 40% to 90% silica, by weight containing an oxide of a divalent metal, e.g. an oxide of zinc
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Geochemistry & Mineralogy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Ceramic Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Glass Compositions (AREA)

Abstract

A glass ceramic biomaterial (1) comprises SrO, ZnO, CaO, SiO2 and Na2O. The biomaterial (1) has a crystalline atomic structure. The biomaterial (1) is provided in the form of a porous foam. the biomaterial (1) with the crystalline atomic structure is degradable for release of bioactive Sr2+ ions and for release of bioactive Zn2+ ions. The Sr2+ ions may assist with bone regeneration, and the Zn2+ ions may provide an anti-bacterial function. <Figure 1>

Description

This invention relates to a glass ceramic biomaterial.
Statements of Invention ΟΡΪΛ at PtiSUC WSPECTHW « hit 0./3+). ...
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According to the invention there is provided a glass ceramic biomaterial having a crystalline atomic structure, at least part of the biomaterial being degradable for release of bioactive ions.
The structure of the biomaterial enables the biomaterial to be employed in load bearing applications without an additional binding agent and/or cement and/or binding gel being required. The biomaterial may also be employed in non load bearing applications.
By releasing bioactive ions, the biomaterial may assist in promoting a therapeutic response in a body tissue and/or in a body bone and/or in a body part.
In one embodiment of the invention the biomaterial comprises strontium (Sr). Strontium is particularly effective in promoting bone regeneration in bone tissue. Preferably the biomaterial comprises SrO. Ideally the molar percentage of SrO is between 10% and 40%. Most preferably the biomaterial is degradable for release of Sr21 ions.
In another embodiment the biomaterial comprises zinc (Zn). Zinc is particularly effective as an anti-bacterial agent to minimise infection. Preferably the biomaterial PO55EE /Ε 10 0 196 comprises ZnO. Ideally the molar percentage of ZnO is between 0.1% and 30%. Most preferably the biomaterial is degradable for release of Zn2+ ions.
En one case the biomaterial comprises calcium (Ca). Preferably the biomaterial 5 comprises CaO. Ideally the molar percentage of CaO is between 0.1% and 20%.
In another case the biomaterial comprises silicon (Si). Preferably the biomaterial comprises S1O2. Ideally the molar percentage of S1O2 is between 33% and 60%.
In one embodiment the biomaterial comprises sodium (Na). Preferably the biomaterial comprises Na2O. Ideally the molar percentage of NajO is between 0.1% and 40%.
The biomaterial may comprise crystalline strontium zinc silicate. The biomaterial may comprise crystalline sodium calcium silicate. In one case the biomaterial comprises a blend of crystalline strontium zinc silicate and crystalline sodium calcium silicate.
The biomaterial may comprise crystalline sodium zinc silicate. The biomaterial may comprise crystalline calcium silicate. In one case the biomaterial comprises a blend of crystalline sodium zinc silicate and crystalline calcium silicate.
The biomaterial may comprise crystalline strontium silicate. The biomaterial may comprise crystalline sodium silicate. In one case biomaterial comprises a blend of crystalline calcium silicate and crystalline strontium silicate and crystalline sodium silicate. In another case the biomaterial comprises a blend of crystalline strontium zinc silicate and crystalline strontium silicate and crystalline sodium zinc silicate. In a further case the biomaterial comprises a blend of crystalline strontium silicate and crystalline sodium zinc silicate.
IE 100196 P055IE In another embodiment the crystallisation temperature is between 400° C and 900° C. Preferably the crystallisation temperature is between 500° C and 800° C.
In one case the biomaterial comprises a foam. Preferably at least part of the 5 biomaterial is porous. The porous biomaterial may assist in promoting tissue ingrowth.
The invention also provides in another aspect the use of a glass ceramic biomaterial of die invention for prophylactic treatment at a bone tissue fracture site.
In a further aspect of the invention there is provided the use of a glass ceramic biomaterial of the invention as a bone tissue autograft extender.
The invention also provides in another aspect the use of a glass ceramic biomaterial of the invention as a radiopacifier and/or as a coating for a heart tissue.
Brief Description of the Drawings The invention will be more clearly understood from the following description of some embodiments thereof, given by way of example only, with reference to the accompanying drawings, in which: Fig. 1 is an X-ray tomography image of a glass ceramic biomaterial according to the invention, Fig. 2 is a graph illustrating the phase transformation of the glass ceramic biomaterial of Fig. 1, IE 10 0 19 6 PO55IE Fig. 3 is an X-ray tomography image of four cross sections of the glass ceramic biomaterial of Fig. I, Figs. 3(a) to 3(d) are graphs illustrating the phase transformation of four other glass 5 ceramic biomaterials according to the invention, Fig. 4 is a graph illustrating ion release for the glass ceramic biomaterial of Fig. 1 and three of the glass ceramic biomaterials of Figs. 3(a) to 3(d), and Fig. 5 is an image of the glass ceramic biomaterial of Fig. 1 with a precipitate apatite bioactive coating.
Detailed Description Referring to the drawings, and initially to Figs. 1 to 3 thereof, there is illustrated a glass ceramic biomaterial 1 according to the invention.
The biomaterial 1 comprises strontium (Sr), zinc (Zn), calcium (Ca), silicon (Si), and sodium (Na). In particular the biomaterial 1 comprises SrO, ZnO, CaO, S1O2 and Na2O. In this case the biomaterial 1 consists of SrO, ZnO, CaO, S1O2 and Na2O and is free of any further binding agents and/or cements and/or binding gels. The molar percentage of SrO may be between 10% and 40%. The molar percentage of ZnO may be between 0.1% and 30%. The molar percentage of CaO may be between 0.1% and 20%. The molar percentage of S1O2 may be between 33% and 60%. The molar percentage of Na2O may be between 0.1% and 40%. In this case the molar percentage of SrO is 20%, the molar percentage of ZnO is 20%, the molar percentage of CaO is 10%, the molar percentage of S1O2 is 40%, and the molar percentage of Na2O is 10%. /f 100 1 9β P0S5E The biomaterial 1 has a crystalline atomic structure. In this case the biomaterial 1 comprises a blend of crystalline strontium zinc silicate and crystalline sodium calcium silicate. The biomaterial 1 is provided in the form of a porous foam.
The crystallisation temperature of the biomaterial 1 may be between 400° C and 900° C, and preferably is between 500° C and 800° C. In this case the crystallisation temperature ofthe biomaterial 1 is 713° C.
Fig. 2 illustrates the phase transformation of the basic glass composition into the 10 biomaterial 1 at the first crystallization point (Tpi). During processing, the basic glass composition converts from an amorphous glass into the blend of crystalline strontium zinc silicate and crystalline sodium calcium silicate at the first crystallization point (Tpi), as illustrated in Fig. 2. This conversion radically alters the structural characteristics and properties of the biomaterial 1 in comparison to the basic glass composition.
Surprisingly the biomaterial 1 with the crystalline atomic structure is degradable for release of bioactive ions. In this case the biomaterial 1 is degradable for release of Sr2+ ions and for release of Zn2+ ions. Fig. 4 illustrates the Zn2+ ion release at 7 days and at 30 days maturation under Ph3 and Ph7. It would have been expected that the processing of the basic glass composition would have resulted in a stable inert glass ceramic, and it would have been expected that the resulting atomic structure would not have enabled any ion release. Contrary to what would have been conventionally expected, it has been found unexpectedly that the processing of the basic glass composition results in the biomaterial 1 with the crystalline atomic structure which provides for degradation and release of constituent ions, as illustrated in Fig. 4.
The glass based biomaterial 1 releases ions which may lead to a therapeutic response for example in a bone prosthesis in a human body. The Sr2* ions may assist with bone regeneration, and the Zn2+ ions may provide an anti-bacterial function. The IE 100 7 96 PO55IE biomaterial 1 offers the controlled release of ions which are known to inhibit bacterial colonisation of implants and synergistically release ions which promote osteoblastic bone formation at the expense of osteoclastic bone resorption. The biomaterial 1 offers a synergy of antibacterial and regenerative ion release. In the biomaterial 1, the Zn2+ ions are released at levels appropriate to inhibit infection in vivo.
The bioactive glass of the invention comprises Calcium-Strontium-Zinc-Silicate.
The glass releases controlled amounts of therapeutic Zn2+ and Sri+ ions when placed in normal and extreme physiological conditions. The bioactive glass is suited to utilize as a bone replacement material. The level of Zn2+ and Sr2-1· ions released from the bioactive glass material achieve clinical benefits and therapeutic effects including bone formation in the range of 2.45 to 6.5 parts per million (ppm), and antibacterial efficacy of 3-7 ppm respectively.
The crystalline atomic structure of the biomaterial 1 is a function of the composition of the biomaterial 1, the processing temperature to produce the biomaterial 1, and the length of time which the biomaterial 1 is processed at this temperature. The invention provides a glass ceramics construct with a synergistic composition of Sr2+ and Zn2+ in which the crystalline atomic structure may be chosen to alter the material properties of the biomaterial 1.
The biomaterial 1 is provided in the form of a solid, load-bearing structure. No further binding agents and/or cements and/or binding gels are required with the 25 biomaterial 1. The biomaterial 1 has the ability to bear loads normal to physiological loading in the skeleton. The biomaterial 1 may also be deployed as a non loadbearing element Fig. 1 illustrates an X-ray tomography (XRT) image of the foam biomaterial 1. The porous nature of the biomaterial 1 facilitates tissue in-growth.
IE 10 0 1 96 The glass ceramic biomaterial 1 may be deployed as a fully reticulated foam, a bulk biomaterial or a coating. The biomaferial 1 is suitable for the following fields of use: load-bearing and non load-bearing dental, craniofacial, maxillofacial and/or orthopaedic applications. infection may be an ongoing clinical concern, both immediate to introduction of biomaterials in the body and for the long term viability of the in vivo construct. The biomaterial 1 offers an antibacterial solution to reduce infection at the post-operative stage, whilst also offering full porosity for bone in-growth, and load bearing capabilities for increased scope of applications. In respect of patients who suffer from metabolic hone diseases such as osteoporosis, the invention provides for controlled release of therapeutic agents, such as Sr2+, from a load bearing construct either foam, bulk or coating. The inclusion of Sr2* in synergy with Zn2+ also offers significant advantages in bone regeneration as a function of controlled ion release to mediate specific regenerative responses in bone tissue in a material capable of forming a direct bond with bone while retaining bone bonding capabilities, as illustrated in Fig. 5. Fig. 5 illustrates a surface image of the biomaterial 1 immerged in simulated body fluid (SBF) for 7 days showing a precipitate apatite bioactive coating.
The biomaterial 1 has numerous advantages from a material and surgical applications standpoint, for example the capability to release ions, applicability to non loadbearing applications as well as applicability to load-bearing applications, capability of being deployed as a reticulated foam, and being a fully crystalline material, The biomaterial 1 may be employed in a variety of applications, for example for controlled drug delivery, and/or for drug delivery in combination with a hydrogel, and/or for stem cell tissue engineering, and/or as a component in a toothpaste for sensitivity control, and/or as a component in a bone cement for improved radiopacity, Ρ055ΒΕ IE 10 0 19 6 P055IL· and/or as a component in a bone cement for improved biocompatibility and/or antibacterial efficacy, and/or as a component of a composite biomaterial for tissue engineering, and/or as a coating on a medical device.
The biomaterial 1 may be used for prophylactic treatment at a bone tissue fracture site, such as the neck of a femur or a vertebra. The biomaterial 1 may be used as a bone tissue autograft extender. The biomaterial 1 may be used as a radiopacifier and/or as a coating for a heart tissue.
The biomaterial 1 may be provided in a variety of shapes, for example as a rod, and/or a plate, and/or a prosthetic bone shape.
Fig. 3 illustrates the XRT montage of the biomaterial 1 of the invention illustrating the interconnected pore structure through multiple cross sections of the biomaterial 1.
In a second embodiment of the invention, the biomaterial comprises SrO, ZnO, CaO, S1O2 and Na2O. In this case the molar percentage of SrO is 20%, the molar percentage of ZnO is 10%, the molar percentage of CaO is 10%, the molar percentage of S1O2 is 40%, and the molar percentage of Na2O is 20%.
In this case the biomaterial comprises a blend of crystalline sodium zinc silicate and crystalline calcium silicate.
In this case the crystallisation temperature of the biomaterial is 577° C.
In a third embodiment of the invention, the biomaterial comprises SrO, CaO, S1O2 and Na2O. In this case the molar percentage of SrO is 20%, the molar percentage of ZnO is 0%, the molar percentage of CaO is 10%, the molar percentage of S1O2 is 40%, and the molar percentage of Na2O is 30%.
IE 10 0 19 6 PO55E In this case the biomaterial comprises a blend of crystalline calcium silicate and crystalline strontium silicate and ciystalline sodium silicate.
In this case the crystallisation temperature of the biomaterial is 525° C.
In a fourth embodiment of the invention, the biomaterial comprises SrO, ZnO, SiO? and Na2O. In this case the molar percentage of SrO is 30%, the molar percentage of ZnO is 20%, the molar percentage of CaO is 0%, the molar percentage of S1O2 is 40%, and the molar percentage of Na?O is 10%.
In this case the biomaterial comprises a blend of crystalline strontium zinc silicate and crystalline strontium silicate and crystalline sodium zinc silicate.
In this case the crystallisation temperature of the biomaterial is 668° C.
In a fifth embodiment of the invention, the biomaterial comprises SrO, ZnO, SiO? and Na?O. In this case the molar percentage of SrO is 30%, the molar percentage of ZnO is 10%, the molar percentage of CaO is 0%, the molar percentage of SiO2 is 40%, and the molar percentage of Na2O is 20%.
In this case the biomaterial comprises a blend of crystalline strontium silicate and crystalline sodium zinc silicate.
In this case the crystallisation temperature of the biomaterial is 567° C.
The following table lists the glass compositions in mol. fractions.
Glass designation SiO 2 ZnO CaO SrO Na2O First embodiment 0.4 0.2 0.1 0.2 0.1 fc 10 0 7 96 ίο P055IE Second embodiment 0.4 0.1 0.1 0.2 0.2 Third embodiment 0.4 0 0.1 0.2 0.3 Fourth embodiment 0.4 0.2 0 0.3 0.1 Fifth embodiment 0.4 0.1 0 0.3 0.2 The following table lists the glass compositions with the crystalline compounds formed at Tpi. Tpi is the first crystallization point, which is the temperature at which the glass converts fully to a crystalline ceramic.
Glass-Ceramic Designate TPi(°C) Crystalline Compound Formed at Tpi First embodiment 713 Strontium Zinc Silicate Sodium Calcium Silicate Second embodiment 577 Sodium Zinc Silicate Calcium Silicate Third embodiment 525 Calcium Silicate Strontium Silicate Sodium Silicate Fourth embodiment 668 Strontium Zinc Silicate Strontium Silicate Sodium Zinc Silicate Fifth embodiment 567 Strontium Silicate Sodium Zinc Silicate Figs. 3(a) to 3(d) illustrate an XRD trace for each biomaterial 2, 3,4,5 after processing at the respective Tpl. fe 100196 P055IE The invention is not limited to the embodiments hereinbefore described, with reference to the accompanying drawings, which may be varied in construction and detail.

Claims (34)

Claims
1. A glass ceramic biomaterial having a crystalline atomic structure, at least part of the biomaterial being degradable for release of bioactive ions.
2. A biomaterial as claimed in claim 1 wherein the biomaterial comprises strontium (Sr).
3. A biomaterial as claimed in claim 2 wherein the biomaterial comprises SrO.
4. A biomaterial as claimed in claim 3 wherein the molar percentage of SrO is between 10% and 40%.
5. A biomaterial as claimed in any of claims 2 to 4 wherein the biomaterial is 15 degradable for release of Sr 2 * ions.
6. A biomaterial as claimed in any of claims 1 to 5 wherein the biomaterial comprises zinc (Zn). 20
7. A biomaterial as claimed in claim 6 wherein the biomaterial comprises ZnO.
8. A biomaterial as claimed in claim 7 wherein the molar percentage of ZnO is between 0.1% and 30%. 25
9. A biomaterial as claimed in any of claims 6 to 8 wherein the biomaterial is degradable for release of Zn 2 * ions.
10. A biomaterial as claimed in any of claims 1 to 9 wherein the biomaterial comprises calcium (Ca). ΙΕ ί Ο Ο ί 9 g PO55E
11. A biomaterial as claimed in claim 10 wherein the biomaterial comprises CaO.
12. A biomaterial as claimed in claim 11 wherein the molar percentage of CaO is between 0.1% and 20%.
13. A biomaterial as claimed in any of claims 1 to 12 wherein the biomaterial comprises silicon (Si).
14. A biomaterial as claimed in claim 13 wherein the biomaterial comprises S1O2.
15. A biomaterial as claimed in claim 14 wherein the molar percentage of S1O2 is between 33% and 60%.
16. A biomaterial as claimed in any of claims 1 to 15 wherein the biomaterial 15 comprises sodium (Na).
17. A biomaterial as claimed in claim 16 wherein the biomaterial comprises Na 2 O. 20
18. A biomaterial as claimed in claim 17 wherein the molar percentage of Na2<) is between 0.1% and 40%.
19. A biomaterial as claimed in any of claims 1 to 18 wherein the biomaterial comprises crystalline strontium zinc silicate.
20. A biomaterial as claimed in any of claims 1 to 19 wherein the biomaterial comprises crystalline sodium calcium silicate. IE 100196 P055IE
21. A biomaterial as claimed in claims 19 and 20 wherein the biomaterial comprises a blend of crystalline strontium zinc silicate and crystalline sodium calcium silicate. 5
22. A biomaterial as claimed in any of claims 1 to 21 wherein the biomaterial comprises crystalline sodium zinc silicate.
23. A biomaterial as claimed in any of claims 1 to 22 wherein the biomaterial comprises crystalline calcium silicate.
24. A biomaterial as claimed in claims 22 and 23 wherein the biomaterial comprises a blend of crystalline sodium zinc silicate and crystalline calcium silicate. 15 25. A biomaterial as claimed in any of claims 1 to 24 wherein the biomaterial comprises crystalline strontium silicate. 26. A biomaterial as claimed in any of claims 1 to 25 wherein tiie biomaterial comprises crystalline sodium silicate. 27. A biomaterial as claimed in claims 23,25 and 26 wherein the biomaterial comprises a blend of crystalline calcium silicate and crystalline strontium silicate and crystalline sodium silicate.
25. 28. A biomaterial as claimed in claims 19,25 and 22 wherein the biomaterial comprises a blend of crystalline strontium zinc silicate and crystalline strontium silicate and crystalline sodium zinc silicate. IE 10 0 7 9 6 PO55IE
26. 29. A biomaterial as claimed in claims 25 and 22 wherein the biomaterial comprises a blend of ciystalline strontium silicate and crystalline sodium zinc silicate. 5
27. 30. A biomaterial as claimed in any of claims 1 to 29 wherein the crystallisation temperature is between 400° C and 900° C.
28. 31. A biomaterial as claimed in claim 30 wherein the crystallisation temperature is between 500° C and 800° C.
29. 32. A biomaterial as claimed in any of claims 1 to 31 wherein the biomaterial comprises a foam.
30. 33. A biomaterial as claimed in any of claims 1 to 32 wherein at least part of the 15 biomaterial is porous.
31. 34. A glass ceramic biomaterial substantially as hereinbefore described with reference to the accompanying drawings. 20
32. 35. Use of a glass ceramic biomaterial as claimed in any of claims 1 to 34 for prophylactic treatment at a bone tissue fracture site.
33. 36. Use of a glass ceramic biomaterial as claimed in any of claims 1 to 34 as a bone tissue autograft extender.
34. 37. Use of a glass ceramic biomaterial as claimed in any of claims 1 to 34 as a radiopacifier and/or as a coating for a heart tissue.
IE20100196A 2010-04-01 2010-04-01 A glass ceramical biomaterial IE20100196A1 (en)

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IE20100196A IE20100196A1 (en) 2010-04-01 2010-04-01 A glass ceramical biomaterial
PCT/EP2011/055039 WO2011121087A1 (en) 2010-04-01 2011-03-31 A glass ceramic biomaterial

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CN102380127A (en) * 2011-11-09 2012-03-21 同济大学 Preparation method and application of antibacterial glass coating of antibacterial bone fracture plate
US20140050765A1 (en) * 2012-08-14 2014-02-20 Bio2 Technologies, Inc. Devices and Methods for Tissue Engineering
US20150369803A1 (en) * 2013-01-31 2015-12-24 Dina Katsir Low fluorescence utensils
WO2018014120A1 (en) 2016-07-20 2018-01-25 Mark Robert Towler Glasses, cements and uses thereof
CN112441742A (en) * 2019-08-30 2021-03-05 江苏启灏医疗科技有限公司 Bioactive glass, nasal cavity stent composite material and application thereof
CN114137008B (en) * 2021-11-30 2024-03-01 重庆登康口腔护理用品股份有限公司 Method for detecting bioactive ceramic active ingredients in toothpaste

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DE102004026432A1 (en) * 2004-05-29 2005-12-22 Schott Ag Glass compositions as antimicrobial additive for dental materials and their use
WO2008104964A2 (en) * 2007-02-26 2008-09-04 University Of Limerick A synthetic bone graft
WO2010003191A1 (en) * 2008-07-10 2010-01-14 The University Of Sydney Biocompatible material and uses thereof

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