HUT71270A - Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride - Google Patents
Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chlorideInfo
- Publication number
- HUT71270A HUT71270A HU9500490A HU9500490A HUT71270A HU T71270 A HUT71270 A HU T71270A HU 9500490 A HU9500490 A HU 9500490A HU 9500490 A HU9500490 A HU 9500490A HU T71270 A HUT71270 A HU T71270A
- Authority
- HU
- Hungary
- Prior art keywords
- dichloro
- fluoronicotinic acid
- improved process
- synthesis
- fluoronicotinoyl chloride
- Prior art date
Links
- AATVXELAYCLVTJ-UHFFFAOYSA-N 2,6-dichloro-5-fluoropyridine-3-carbonyl chloride Chemical compound FC1=CC(C(Cl)=O)=C(Cl)N=C1Cl AATVXELAYCLVTJ-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- GCRNGPNGNJSZCC-UHFFFAOYSA-N tert-butyl 3-amino-3a,4,6,6a-tetrahydro-1h-pyrrolo[3,4-c]pyrazole-5-carboxylate Chemical compound N1N=C(N)C2CN(C(=O)OC(C)(C)C)CC21 GCRNGPNGNJSZCC-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- -1 2,6-dihydroxy-5-fluoronicotinic acid ester Chemical class 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/932,452 US5204478A (en) | 1992-08-20 | 1992-08-20 | Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9500490D0 HU9500490D0 (en) | 1995-04-28 |
| HUT71270A true HUT71270A (en) | 1995-11-28 |
| HU214908B HU214908B (hu) | 1998-07-28 |
Family
ID=25462348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9500490A HU214908B (hu) | 1992-08-20 | 1993-07-19 | Eljárás 2,6-diklór-5-fluor-nikotinsav és 2,6-diklór-5-fluor-nikotinoil-klorid szintézisére |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5204478A (hu) |
| EP (1) | EP0655998B1 (hu) |
| JP (1) | JP3287845B2 (hu) |
| KR (1) | KR100281313B1 (hu) |
| AT (1) | ATE151754T1 (hu) |
| AU (1) | AU668412B2 (hu) |
| CA (1) | CA2141046C (hu) |
| CZ (1) | CZ286204B6 (hu) |
| DE (1) | DE69309935T2 (hu) |
| HU (1) | HU214908B (hu) |
| MX (1) | MX9305053A (hu) |
| NZ (1) | NZ254628A (hu) |
| RU (1) | RU2114831C1 (hu) |
| SK (1) | SK280982B6 (hu) |
| WO (1) | WO1994004501A1 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739342A (en) * | 1997-03-03 | 1998-04-14 | Abbott Laboratories | Process for the preparation of nicotinic acids |
| US20030129292A1 (en) * | 1998-04-02 | 2003-07-10 | Lipton | Tomato paste and sauce and process for preparation |
| JP4147190B2 (ja) * | 2001-10-15 | 2008-09-10 | エルジー・ライフ・サイエンシーズ・リミテッド | β−ケトエステル化合物の製造方法 |
| US6624307B1 (en) * | 2002-03-28 | 2003-09-23 | Isp Investments Inc. | Process for producing 2,6-dihydroxy-3,4-dialkylpyridines |
| JP4765623B2 (ja) * | 2003-05-09 | 2011-09-07 | 旭硝子株式会社 | ２−クロロ−５−フルオロ−３−置換ピリジンまたはその塩の製造方法 |
| CN113735785B (zh) * | 2020-05-28 | 2023-10-13 | 南京桦冠生物技术有限公司 | 3,6-二氯吡嗪-2-甲腈的制备方法 |
| CN114181139B (zh) * | 2021-12-27 | 2023-12-08 | 四川仁安药业有限责任公司 | 一种5-卤代烟酸的合成方法 |
| CN114591225B (zh) * | 2022-03-02 | 2024-02-06 | 河南阿尔法医药科技有限公司 | 一种可规模化生产2,6-二溴-4-甲基吡啶的方法 |
| CN117263854A (zh) * | 2023-09-15 | 2023-12-22 | 山东友聚医药科技有限公司 | 一种2,5,6-三氯烟酸的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH428763A (de) * | 1960-05-04 | 1967-01-31 | Glaxo Group Ltd | Verfahren zur Herstellung von Enhalogeniden von Grisantrion-(3,2',4') |
| EP0160578B1 (en) * | 1984-02-17 | 1989-11-23 | Daiichi Seiyaku Co., Ltd. | 1,8-naphthyridine derivatives |
| EP0333020A3 (en) * | 1988-03-18 | 1991-03-20 | Abbott Laboratories | Process for the preparation of substituted pyridines |
-
1992
- 1992-08-20 US US07/932,452 patent/US5204478A/en not_active Expired - Lifetime
-
1993
- 1993-07-19 HU HU9500490A patent/HU214908B/hu not_active IP Right Cessation
- 1993-07-19 KR KR1019950700627A patent/KR100281313B1/ko not_active Expired - Fee Related
- 1993-07-19 RU RU95108386A patent/RU2114831C1/ru not_active IP Right Cessation
- 1993-07-19 DE DE69309935T patent/DE69309935T2/de not_active Expired - Fee Related
- 1993-07-19 NZ NZ254628A patent/NZ254628A/en unknown
- 1993-07-19 CZ CZ1995388A patent/CZ286204B6/cs not_active IP Right Cessation
- 1993-07-19 AU AU46823/93A patent/AU668412B2/en not_active Ceased
- 1993-07-19 SK SK232-95A patent/SK280982B6/sk unknown
- 1993-07-19 JP JP50625794A patent/JP3287845B2/ja not_active Expired - Fee Related
- 1993-07-19 EP EP93917246A patent/EP0655998B1/en not_active Expired - Lifetime
- 1993-07-19 AT AT93917246T patent/ATE151754T1/de not_active IP Right Cessation
- 1993-07-19 CA CA002141046A patent/CA2141046C/en not_active Expired - Fee Related
- 1993-07-19 WO PCT/US1993/006727 patent/WO1994004501A1/en not_active Ceased
- 1993-08-19 MX MX9305053A patent/MX9305053A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK23295A3 (en) | 1995-07-11 |
| CA2141046C (en) | 2004-03-23 |
| DE69309935T2 (de) | 1997-10-23 |
| KR950702965A (ko) | 1995-08-23 |
| SK280982B6 (sk) | 2000-10-09 |
| RU95108386A (ru) | 1997-03-20 |
| EP0655998B1 (en) | 1997-04-16 |
| WO1994004501A1 (en) | 1994-03-03 |
| US5204478A (en) | 1993-04-20 |
| HU9500490D0 (en) | 1995-04-28 |
| ATE151754T1 (de) | 1997-05-15 |
| EP0655998A1 (en) | 1995-06-07 |
| DE69309935D1 (de) | 1997-05-22 |
| HU214908B (hu) | 1998-07-28 |
| KR100281313B1 (ko) | 2001-02-01 |
| CZ38895A3 (en) | 1995-12-13 |
| MX9305053A (es) | 1994-02-28 |
| AU4682393A (en) | 1994-03-15 |
| JPH08500358A (ja) | 1996-01-16 |
| NZ254628A (en) | 1996-01-26 |
| JP3287845B2 (ja) | 2002-06-04 |
| AU668412B2 (en) | 1996-05-02 |
| RU2114831C1 (ru) | 1998-07-10 |
| CA2141046A1 (en) | 1994-03-03 |
| CZ286204B6 (cs) | 2000-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |