HUT63418A - 2-(2-substituted pyrrholidinyl-thio)carbapeneme derivatives and medical preparatives containing them as active substance - Google Patents

2-(2-substituted pyrrholidinyl-thio)carbapeneme derivatives and medical preparatives containing them as active substance

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Publication number
HUT63418A
HUT63418A HU939300647A HU9300647A HUT63418A HU T63418 A HUT63418 A HU T63418A HU 939300647 A HU939300647 A HU 939300647A HU 9300647 A HU9300647 A HU 9300647A HU T63418 A HUT63418 A HU T63418A
Authority
HU
Hungary
Prior art keywords
opt
substd
pyrrholidinyl
thio
substituted
Prior art date
Application number
HU939300647A
Other languages
Hungarian (hu)
Other versions
HU9300647D0 (en
Inventor
Susumu Nakagawa
Norizaku Ohtake
Shigemitsu Okada
Ryosuke Ushijima
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Priority claimed from PCT/JP1992/000864 external-priority patent/WO1993001192A1/en
Publication of HU9300647D0 publication Critical patent/HU9300647D0/en
Publication of HUT63418A publication Critical patent/HUT63418A/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Carbapenem derivs. of formula (I) and their salts and esters are new: R1 = H or Me; R2 = H or a negative charge; R3 = H or lower alkyl; R4-R6 = H, CN, SO2Me, opt. substd. lower alkyl, opt. substd. carbamoyl or XNR7R8, at least one being XNR7R8; R7 and R8 = H or opt. substd. lower alkyl, or NR7R8 is an opt. substd. 3- to 8-membered ring, opt. contg. another N, O or S heteroatom, opt. with a quaternary N atom; X = opt. substd. lower alkylene; Y = lower alkylene or a single bond. - 26 Cpds. (I) are specifically claimed including: (1R,5S,6S)-2-((2S,4S)-2-((Z)- 3-amino-1-propenyl) -4-pyrrolidinylthio)- 6-((R)-1-hydroxyethyl)- 1-methyl-1-carba-2-penem- 3-carboxylic acid (Ia).
HU939300647A 1991-07-09 1992-07-07 2-(2-substituted pyrrholidinyl-thio)carbapeneme derivatives and medical preparatives containing them as active substance HUT63418A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19476791 1991-07-09
JP34959191 1991-12-07
PCT/JP1992/000864 WO1993001192A1 (en) 1991-07-09 1992-07-07 2-(2-substituted pyrrolidinylthio)carbapenem derivatives

Publications (2)

Publication Number Publication Date
HU9300647D0 HU9300647D0 (en) 1993-05-28
HUT63418A true HUT63418A (en) 1993-08-30

Family

ID=27306902

Family Applications (1)

Application Number Title Priority Date Filing Date
HU939300647A HUT63418A (en) 1991-07-09 1992-07-07 2-(2-substituted pyrrholidinyl-thio)carbapeneme derivatives and medical preparatives containing them as active substance

Country Status (1)

Country Link
HU (1) HUT63418A (en)

Also Published As

Publication number Publication date
HU9300647D0 (en) 1993-05-28

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary prot. due to refusal