HUT62871A - Process for producing 2-chlorothiazole derivatives - Google Patents

Process for producing 2-chlorothiazole derivatives

Info

Publication number
HUT62871A
HUT62871A HU340291A HU340291A HUT62871A HU T62871 A HUT62871 A HU T62871A HU 340291 A HU340291 A HU 340291A HU 340291 A HU340291 A HU 340291A HU T62871 A HUT62871 A HU T62871A
Authority
HU
Hungary
Prior art keywords
formula
methyl
iii
give
thiazole
Prior art date
Application number
HU340291A
Other languages
Hungarian (hu)
Other versions
HU215840B (en
HU913402D0 (en
Inventor
Endre Palosi
Dezsoe Korbonits
Leventene Molnar
Gyoergyne Szvoboda
Gergely Heja
Pal Kiss
Csaba Goenczi
Ferencne Morasz
Laszlo Ledniczky
Kardos Erzsebet Szabone
Peter Gyoery
Erzsebet Szalay
Ferenc Sperber
Csaba Huszar
Gyoergy Mihalovics
Attila Nemeth
Mihaly Suetoe
Karoly Gyuere
Istvan Bone
Karoly Ban
Ildiko Buttkai
Arpad Koevari
Sandor Garaczy
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to HU3402/91A priority Critical patent/HU215840B/en
Publication of HU913402D0 publication Critical patent/HU913402D0/en
Priority to HR1125/92A priority patent/HRP921128B1/en
Priority to IL103586A priority patent/IL103586A/en
Priority to IS3937A priority patent/IS1688B/en
Priority to SK501-94A priority patent/SK279665B6/en
Priority to EP92118606A priority patent/EP0546306B1/en
Priority to DE69219154T priority patent/DE69219154T2/en
Priority to CA002121488A priority patent/CA2121488A1/en
Priority to HU9401262A priority patent/HU217079B/en
Priority to JP50829893A priority patent/JP3190959B2/en
Priority to YU95292A priority patent/YU95292A/en
Priority to EP92923097A priority patent/EP0619815B1/en
Priority to AT92923097T priority patent/ATE151761T1/en
Priority to PCT/HU1992/000042 priority patent/WO1993009107A1/en
Priority to ES92923097T priority patent/ES2100365T3/en
Priority to UA94005498A priority patent/UA34443C2/en
Priority to RU94022467A priority patent/RU2103264C1/en
Priority to PL92303342A priority patent/PL172013B1/en
Priority to AU29123/92A priority patent/AU664868B2/en
Priority to SI9200292A priority patent/SI9200292B/en
Priority to CZ941034A priority patent/CZ283402B6/en
Priority to US08/232,207 priority patent/US5648498A/en
Priority to KR1019940701422A priority patent/KR100218131B1/en
Priority to DK92923097.7T priority patent/DK0619815T3/en
Publication of HUT62871A publication Critical patent/HUT62871A/en
Priority to NO940004A priority patent/NO304650B1/en
Priority to FI941996A priority patent/FI105476B/en
Priority to US08/464,308 priority patent/US5534644A/en
Priority to GR970401480T priority patent/GR3023842T3/en
Priority to HK93397A priority patent/HK93397A/en
Priority to LVP-98-68A priority patent/LV12130B/en
Publication of HU215840B publication Critical patent/HU215840B/en

Links

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  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Prepn. of 4-methyl-5-(2-chloroalkyl)-thiazole derivs. of formula (I) and their acid addn. salts comprises reacting a 3-thiocyanato-5-chloro- 2-alkanone of formula (II) either: with HCl gas in an organic solvent to give a 2-chloro-4-methyl-5-(2-chloroalky l)-thiazole of formula (III), or; with an aq. mineral acid to give a 2-hydroxy-4-methyl- 5-(2-chloroalkyl)-thiazole of formula (IV) which is treated with a halogenating agent to give (III); followed by hydrogenation of (III) in the presence of a metal catalyst in an organic solvent. In formulae R = 1-5C alkyl, 2-substd. by Cl. Intermediates (II) are new.
HU3402/91A 1991-10-30 1991-10-30 Process for producing 2-chlorothiazole derivatives HU215840B (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
HU3402/91A HU215840B (en) 1991-10-30 1991-10-30 Process for producing 2-chlorothiazole derivatives
HR1125/92A HRP921128B1 (en) 1991-10-30 1992-10-29 Novel process for the preparation of 4-methyl-5(2-chloroethyl)-thiazole and analogues thereof
IL103586A IL103586A (en) 1991-10-30 1992-10-29 Process for the preparation of 4-methyl-5- (2-chloroethyl)-thiazole and analogues thereof
IS3937A IS1688B (en) 1991-10-30 1992-10-29 A novel process for the preparation of 4-methyl-5- (2-chloroethyl) thiazole and its analogues and novel intermediates in the preparation of the compounds
DK92923097.7T DK0619815T3 (en) 1991-10-30 1992-10-30 Process for the preparation of 4-methyl-5- (2-chloroethyl) -thiazole and analogs thereof
ES92923097T ES2100365T3 (en) 1991-10-30 1992-10-30 PROCEDURE TO PREPARE 4-METHYL-5- (2-CHLOROETHYL) -TIAZOL AND ITS ANALOGS.
PL92303342A PL172013B1 (en) 1991-10-30 1992-10-30 Method of obtaining 4-methyl-5-(2-chloroalkyl)-thiazoles
DE69219154T DE69219154T2 (en) 1991-10-30 1992-10-30 METHOD FOR PRODUCING 4-METHYL-5- (2-CHLORETHYL) THIAZOL AND ITS ANALOGS
CA002121488A CA2121488A1 (en) 1991-10-30 1992-10-30 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
HU9401262A HU217079B (en) 1991-10-30 1992-10-30 New process for producing 5-(2-chloroalkyl)-thiazole derivatives
JP50829893A JP3190959B2 (en) 1991-10-30 1992-10-30 Novel process for producing 4-methyl-5- (2-chloroethyl) -thiazole and its homologues
YU95292A YU95292A (en) 1991-10-30 1992-10-30 A NEW PROCEDURE FOR THE PREPARATION OF 4-METHYL-5 - (- 2-CHLORO-ETHYL) -THIAZOLE AND ITS ANALOGS
EP92923097A EP0619815B1 (en) 1991-10-30 1992-10-30 Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
AT92923097T ATE151761T1 (en) 1991-10-30 1992-10-30 METHOD FOR PRODUCING 4-METHYL-5-(2-CHLORETHYL)-THIAZOLE AND ANALOGUES THEREOF
PCT/HU1992/000042 WO1993009107A1 (en) 1991-10-30 1992-10-30 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
SK501-94A SK279665B6 (en) 1991-10-30 1992-10-30 Process for the preparation of 4-methyl-5-(2-chloroalkyl)thiazole
UA94005498A UA34443C2 (en) 1991-10-30 1992-10-30 Process for the preparation of the thiazole derivatives or acid addition salts thereof, 3-thiocyanato-5-chloro-2-alkanone and a process for its preparation
RU94022467A RU2103264C1 (en) 1991-10-30 1992-10-30 Method for producing derivatives of thiazole or their acid additive salts, 5-chloro-3-thiocyanate-2-alkanone and method for its production
EP92118606A EP0546306B1 (en) 1991-10-30 1992-10-30 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation
AU29123/92A AU664868B2 (en) 1991-10-30 1992-10-30 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
SI9200292A SI9200292B (en) 1991-10-30 1992-10-30 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues derivatives
CZ941034A CZ283402B6 (en) 1991-10-30 1992-10-30 Process for preparing 4-methyl-5-(2-chloroalkyl)thiazole derivative and 4-thiocyanato-5-chloro-2-alkanone employed as intermediate during said process
US08/232,207 US5648498A (en) 1991-10-30 1992-10-30 Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
KR1019940701422A KR100218131B1 (en) 1991-10-30 1992-10-30 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
NO940004A NO304650B1 (en) 1991-10-30 1994-04-28 New Process for Preparation of 4-Methyl-5- (2-Chloroethyl) Thiazole and Analogs thereof
FI941996A FI105476B (en) 1991-10-30 1994-04-29 New Process for Preparation of 4-Methyl-5- (2-chloroethyl) -thiazole and its Analogs
US08/464,308 US5534644A (en) 1991-10-30 1995-06-05 Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
GR970401480T GR3023842T3 (en) 1991-10-30 1997-06-19 Novel process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof.
HK93397A HK93397A (en) 1991-10-30 1997-06-26 Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
LVP-98-68A LV12130B (en) 1991-10-30 1998-04-16 5-(2-chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU3402/91A HU215840B (en) 1991-10-30 1991-10-30 Process for producing 2-chlorothiazole derivatives

Publications (3)

Publication Number Publication Date
HU913402D0 HU913402D0 (en) 1992-01-28
HUT62871A true HUT62871A (en) 1993-06-28
HU215840B HU215840B (en) 1999-04-28

Family

ID=10963903

Family Applications (1)

Application Number Title Priority Date Filing Date
HU3402/91A HU215840B (en) 1991-10-30 1991-10-30 Process for producing 2-chlorothiazole derivatives

Country Status (1)

Country Link
HU (1) HU215840B (en)

Also Published As

Publication number Publication date
HU215840B (en) 1999-04-28
HU913402D0 (en) 1992-01-28

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Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: AKTIEBOLAGET ASTRA, SE

HMM4 Cancellation of final prot. due to non-payment of fee