HUT58054A - Process for producing tetralins, chromans and similar compounds for treating asthma - Google Patents

Process for producing tetralins, chromans and similar compounds for treating asthma

Info

Publication number
HUT58054A
HUT58054A HU876043A HU604387A HUT58054A HU T58054 A HUT58054 A HU T58054A HU 876043 A HU876043 A HU 876043A HU 604387 A HU604387 A HU 604387A HU T58054 A HUT58054 A HU T58054A
Authority
HU
Hungary
Prior art keywords
alkyl
isoxazolyl
benzo
tetralins
chromans
Prior art date
Application number
HU876043A
Other languages
Hungarian (hu)
Other versions
HU209292B (en
Inventor
James Frederick Eggler
Anthony Marfat
Lawrence S Melvin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to HU876043A priority Critical patent/HU209292B/en
Priority claimed from PCT/US1987/002734 external-priority patent/WO1989003681A1/en
Publication of HUT58054A publication Critical patent/HUT58054A/en
Publication of HU209292B publication Critical patent/HU209292B/en

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bicyclic cpds. of formula (I) and their salts are new: where n = 0 or 1; X = CH2, O, S, SO, SO2, NH or 1-4C alkylamino; X1 = CH2, O, S, SO or SO2; Y + Y1 = O, or Y = H and Y1 = OH or in-vivo hydrolysable acyloxy; Z = CH2, CHMe, CH2CH2 or CH2CH2CH2; Z1 = CH or N; R = 2-, 3- or 4-pyridyl, 2-, 3- or 4-quinolyl, 1-, 3- or 4-isoquinolyl, 3- or 4-pyridazinyl, 3- or 4-cinnolinyl, 1-phthalazinyl, 2- or 4-pyrimidinyl, 2- or 4-quinazolinyl, 2-pyrazinyl, 2-quinozalinyl, 1-, or 2- or 3-indolizinyl, 2-, 4- or 5-oxazolyl, 2-benzoxazolyl, 3-4- or 5- isoxazolyl, 5-benzo(c)isoxazolyl, 3-benzo(d)isoxazolyl, 2-, 4- or 5-thiazolyl, 2-benzothiazolyl, 3-, 4- or 5-isothiazolyl, 5-benzo(c)isothiazolyl, 1-R1-2-, -4- or -5-imidazolyl, 1-R1-2-benzimidazolyl, 1-R1-3-, -4- or 5-pyrazolyl, 2-R1-3(2H)-indazolyl or 1-R1-3(1H)-indazolyl, all opt. mono- or disubstd. on C atoms by Br, Cl, F, 1-4C alkyl, CF3, OH, CH2OH and/or 1-4C alkoxy or an adjacent C atoms by (CH2)3, (CH2)4, CH2OCH2 or OCH2O; R1 = 1-4C alkyl; R1 = 1-8C alkyl, 3-8C cycloalkyl, 7-10C bicycloalkyl, 4-10C cycloalkylalkyl or 8-11C bicycloalkylalkyl, all opt. mono- or disubstd. by F, 1-4C alkyl, 1-4C alkoxy, COOH and/or 2-5C alkoxycarbonyl.
HU876043A 1987-10-19 1987-10-19 Process for producing tetralins, chromans and similar compounds for treating asthma HU209292B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU876043A HU209292B (en) 1987-10-19 1987-10-19 Process for producing tetralins, chromans and similar compounds for treating asthma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1987/002734 WO1989003681A1 (en) 1987-10-19 1987-10-19 Substituted tetralins, chromans and related compounds in the treatment of asthma
HU876043A HU209292B (en) 1987-10-19 1987-10-19 Process for producing tetralins, chromans and similar compounds for treating asthma

Publications (2)

Publication Number Publication Date
HUT58054A true HUT58054A (en) 1992-01-28
HU209292B HU209292B (en) 1994-04-28

Family

ID=26317862

Family Applications (1)

Application Number Title Priority Date Filing Date
HU876043A HU209292B (en) 1987-10-19 1987-10-19 Process for producing tetralins, chromans and similar compounds for treating asthma

Country Status (1)

Country Link
HU (1) HU209292B (en)

Also Published As

Publication number Publication date
HU209292B (en) 1994-04-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee