HUT54388A - Process for producing new analogues of stimulator hormone for growth hormone secretion (grf) - Google Patents

Process for producing new analogues of stimulator hormone for growth hormone secretion (grf)

Info

Publication number
HUT54388A
HUT54388A HU893660A HU366089A HUT54388A HU T54388 A HUT54388 A HU T54388A HU 893660 A HU893660 A HU 893660A HU 366089 A HU366089 A HU 366089A HU T54388 A HUT54388 A HU T54388A
Authority
HU
Hungary
Prior art keywords
arg
ala
ser
grf
ile
Prior art date
Application number
HU893660A
Other languages
Hungarian (hu)
Other versions
HU205953B (en
Inventor
Magdolna Kovacs
Judit Horvath
Sandor Vigh
Imre Mezoe
Istvan Teplan
Balazs Szoeke
Janos Seproedi
Zsolt Vadasz
Edit Hegedues
Gabor Makara
Gyoergy Rappay
Original Assignee
Mta Kutatas Es Szervezetelemzo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mta Kutatas Es Szervezetelemzo filed Critical Mta Kutatas Es Szervezetelemzo
Priority to HU366089A priority Critical patent/HU205953B/en
Priority to US07/400,587 priority patent/US5023322A/en
Publication of HUT54388A publication Critical patent/HUT54388A/en
Publication of HU205953B publication Critical patent/HU205953B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel analogues of growth hormone secretion stimulating hormones (GRF) used in human medicine or as active ingredients in compsn. for animal husbandry are prepd. by customary synthetic prepn. methods in peptide chemistry. These hormones are peptides or peptide salts of formula (I). - H-Tyr-R2-As-Ala-Ile-Phe- Thr-Asn-Ser-Tyr-R11-Lys--Leu-Leu-Gln-Asp-Ile -R27-R28-Arg-Gaba-Y. - -R2= Ala. D-Ala; R11= Arg, D-Arg; R13= Val, Ile; R15= Gly, Leu, Phe, chemical bond; R27= Met, Nle; R28= Ser, D-Ser, Asn; Y= -OH, or -NH2 gp., provided that when R4 is Arg. R13 is Val. R15 is Gly, R27 is Nle, R28 is Ser; and Y is -OH or -NH2 gp. then R may only be D-Ala. (1pp Dwg.No.0/0)
HU366089A 1988-08-31 1989-07-19 Process for producing new analogues of growth hormon secretion stimulating hormon and pharmaceutical and veterinaryc compositions containing them as active components HU205953B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU366089A HU205953B (en) 1989-07-19 1989-07-19 Process for producing new analogues of growth hormon secretion stimulating hormon and pharmaceutical and veterinaryc compositions containing them as active components
US07/400,587 US5023322A (en) 1988-08-31 1989-08-30 Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU366089A HU205953B (en) 1989-07-19 1989-07-19 Process for producing new analogues of growth hormon secretion stimulating hormon and pharmaceutical and veterinaryc compositions containing them as active components

Publications (2)

Publication Number Publication Date
HUT54388A true HUT54388A (en) 1991-02-28
HU205953B HU205953B (en) 1992-07-28

Family

ID=10964957

Family Applications (1)

Application Number Title Priority Date Filing Date
HU366089A HU205953B (en) 1988-08-31 1989-07-19 Process for producing new analogues of growth hormon secretion stimulating hormon and pharmaceutical and veterinaryc compositions containing them as active components

Country Status (1)

Country Link
HU (1) HU205953B (en)

Also Published As

Publication number Publication date
HU205953B (en) 1992-07-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee