HUT50185A - New process for production of 6-/(hexahydro-1h-azephin-1-il)-methilen-amin/-penicillin acid /mecillinam/ - Google Patents
New process for production of 6-/(hexahydro-1h-azephin-1-il)-methilen-amin/-penicillin acid /mecillinam/Info
- Publication number
- HUT50185A HUT50185A HU157888A HU157888A HUT50185A HU T50185 A HUT50185 A HU T50185A HU 157888 A HU157888 A HU 157888A HU 157888 A HU157888 A HU 157888A HU T50185 A HUT50185 A HU T50185A
- Authority
- HU
- Hungary
- Prior art keywords
- acid
- mecillinam
- methilen
- azephin
- amin
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
By a novel method 6(7 hexa:hydro-1H-azepine -1-yl)-methylene-amino) penicillanic-acid (mecillinam) is prepd. from 6-amino-penicillanic-acid and N-formyl-hexa-methylene -ammino-di:methyl-sulphate complex in the presence of a tertiary, pref. tri:ethyl-amine. The reaction medium is a bi-polar aprotic solvent as acetonitrile or mixt. of an aprotic solvent and a polar or protic solvent. A catalyst is used. The reaction mix is concentrated in vacuo and the prod. is isolated from its acetone soln. by the addn. of p-toluene-sulphonic-acid of pref. 10 vol.%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU157888A HU201079B (en) | 1988-03-30 | 1988-03-30 | New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU157888A HU201079B (en) | 1988-03-30 | 1988-03-30 | New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam) |
Publications (2)
Publication Number | Publication Date |
---|---|
HUT50185A true HUT50185A (en) | 1989-12-28 |
HU201079B HU201079B (en) | 1990-09-28 |
Family
ID=10955120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU157888A HU201079B (en) | 1988-03-30 | 1988-03-30 | New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam) |
Country Status (1)
Country | Link |
---|---|
HU (1) | HU201079B (en) |
-
1988
- 1988-03-30 HU HU157888A patent/HU201079B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU201079B (en) | 1990-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HMM4 | Cancellation of final prot. due to non-payment of fee |