HUT50185A - New process for production of 6-/(hexahydro-1h-azephin-1-il)-methilen-amin/-penicillin acid /mecillinam/ - Google Patents

New process for production of 6-/(hexahydro-1h-azephin-1-il)-methilen-amin/-penicillin acid /mecillinam/

Info

Publication number
HUT50185A
HUT50185A HU157888A HU157888A HUT50185A HU T50185 A HUT50185 A HU T50185A HU 157888 A HU157888 A HU 157888A HU 157888 A HU157888 A HU 157888A HU T50185 A HUT50185 A HU T50185A
Authority
HU
Hungary
Prior art keywords
acid
mecillinam
methilen
azephin
amin
Prior art date
Application number
HU157888A
Other languages
Hungarian (hu)
Other versions
HU201079B (en
Inventor
Miklos Mihok
Maria Kiss
Sandor Balint
Sandorne Toth
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Priority to HU157888A priority Critical patent/HU201079B/en
Publication of HUT50185A publication Critical patent/HUT50185A/en
Publication of HU201079B publication Critical patent/HU201079B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

By a novel method 6(7 hexa:hydro-1H-azepine -1-yl)-methylene-amino) penicillanic-acid (mecillinam) is prepd. from 6-amino-penicillanic-acid and N-formyl-hexa-methylene -ammino-di:methyl-sulphate complex in the presence of a tertiary, pref. tri:ethyl-amine. The reaction medium is a bi-polar aprotic solvent as acetonitrile or mixt. of an aprotic solvent and a polar or protic solvent. A catalyst is used. The reaction mix is concentrated in vacuo and the prod. is isolated from its acetone soln. by the addn. of p-toluene-sulphonic-acid of pref. 10 vol.%.
HU157888A 1988-03-30 1988-03-30 New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam) HU201079B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU157888A HU201079B (en) 1988-03-30 1988-03-30 New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU157888A HU201079B (en) 1988-03-30 1988-03-30 New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam)

Publications (2)

Publication Number Publication Date
HUT50185A true HUT50185A (en) 1989-12-28
HU201079B HU201079B (en) 1990-09-28

Family

ID=10955120

Family Applications (1)

Application Number Title Priority Date Filing Date
HU157888A HU201079B (en) 1988-03-30 1988-03-30 New process for producing 6-((hexahydro-1h-azepin-1-yl)-methylenamino)-penicillanic acid (mecillinam)

Country Status (1)

Country Link
HU (1) HU201079B (en)

Also Published As

Publication number Publication date
HU201079B (en) 1990-09-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee