HUT46893A - Process for production of optically clean 5-/-/-1-prophil-2-6'-pipecoloxilidid-hydrochlorid
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Process for production of optically clean 5-/-/-1-prophil-2-6'-pipecoloxilidid-hydrochlorid
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Publication number
HUT46893A
HUT46893AHU271187AHU271187AHUT46893AHU T46893 AHUT46893 AHU T46893AHU 271187 AHU271187 AHU 271187AHU 271187 AHU271187 AHU 271187AHU T46893 AHUT46893 AHU T46893A
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Application filed by Astra Laekemedel AbfiledCriticalAstra Laekemedel Ab
Priority to HU271187ApriorityCriticalpatent/HU198689B/en
Publication of HUT46893ApublicationCriticalpatent/HUT46893A/en
Publication of HU198689BpublicationCriticalpatent/HU198689B/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
5-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate (I) is new. Pref. (I) is optically pure, esp. it contains less than 0.5 wt.% of the R-(+) enantiomer. 5-(-)-1-propyl-2',6'- pipecoloxylidide hydrochloride (II) is dissolved in water (pref. 1-3 times by wt. of (II)) then acetone, heated to 45 deg. C to b.pt. added to ppte. (I) Pref. the acetone added is 5-15, esp. 10, times the vol. of water used to make the soln.
HU271187A1987-06-151987-06-15Process for producing optically pure s-/-/-1-propyl-2'6'-pipekoloxilidiol-gidrokhloride-monohydrate and pharmaceutical compositions containing them
HU198689B
(en)