HUT46882A - Process for producing 3-bromo-/2s/-methyl-propionic acid
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Process for producing 3-bromo-/2s/-methyl-propionic acid
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Publication number
HUT46882A
HUT46882AHU251487AHU251487AHUT46882AHU T46882 AHUT46882 AHU T46882AHU 251487 AHU251487 AHU 251487AHU 251487 AHU251487 AHU 251487AHU T46882 AHUT46882 AHU T46882A
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Application filed by Egyt Gyogyszervegyeszeti GyarfiledCriticalEgyt Gyogyszervegyeszeti Gyar
Priority to HU251487ApriorityCriticalpatent/HU197716B/en
Publication of HUT46882ApublicationCriticalpatent/HUT46882A/en
Publication of HU197716BpublicationCriticalpatent/HU197716B/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Optically active 3-bromo-(2S) methyl-propionic acid is prepd. by resolution of racemic 3-bromo-2-methyl-propionic acid. The racemic cpd. is dissolved in a neutral solvent and (R)-3-(3'-4'-dimethoxy -phenyl) -2-methyl-2-amino- propionitrile is added as a resolving agent. The resulting diastereomer is sepd. by crystallisation and opt. recrystallised from a neutral organic solvent Finally 3-bromo-(2S)-methyl-propionic-acid is liberated by an acid from the diastereomer in an aq. medium. The resolving agent may be reused.
HU251487A1987-06-021987-06-02Process for production of 3-brome-/2s/-methil prophion acid
HU197716B
(en)