HUT37620A - Process for production of derivatives of aril or heteroane-/7-aril or heteroane/-pirasolo/1,5-a/-pirimidin-3-il/-methanon and medical preparatives containing such compounds - Google Patents

Process for production of derivatives of aril or heteroane-/7-aril or heteroane/-pirasolo/1,5-a/-pirimidin-3-il/-methanon and medical preparatives containing such compounds

Info

Publication number
HUT37620A
HUT37620A HU842438A HU243884A HUT37620A HU T37620 A HUT37620 A HU T37620A HU 842438 A HU842438 A HU 842438A HU 243884 A HU243884 A HU 243884A HU T37620 A HUT37620 A HU T37620A
Authority
HU
Hungary
Prior art keywords
heteroane
aril
compounds
pirasolo
pirimidin
Prior art date
Application number
HU842438A
Other languages
Hungarian (hu)
Inventor
John P Dusza
Jay D Albright
Andrew S Tomcufcik
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of HUT37620A publication Critical patent/HUT37620A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Aryl and heteroaryl [7-(aryl and heteroaryl)-pyrazolo[1,5-a[pyrimidin-3-yl]methanones which are new compounds active as anxiolytic, anticonvulsant, sedative-hypnotic and skeletal muscle relaxant agents in mammals and the novel process of making these compounds.
HU842438A 1983-06-23 1984-06-22 Process for production of derivatives of aril or heteroane-/7-aril or heteroane/-pirasolo/1,5-a/-pirimidin-3-il/-methanon and medical preparatives containing such compounds HUT37620A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50696683A 1983-06-23 1983-06-23

Publications (1)

Publication Number Publication Date
HUT37620A true HUT37620A (en) 1986-01-23

Family

ID=24016730

Family Applications (1)

Application Number Title Priority Date Filing Date
HU842438A HUT37620A (en) 1983-06-23 1984-06-22 Process for production of derivatives of aril or heteroane-/7-aril or heteroane/-pirasolo/1,5-a/-pirimidin-3-il/-methanon and medical preparatives containing such compounds

Country Status (17)

Country Link
EP (1) EP0129847B1 (en)
JP (1) JPS6019788A (en)
KR (1) KR900001886B1 (en)
AT (1) ATE53391T1 (en)
AU (1) AU568656B2 (en)
CA (1) CA1233174A (en)
DD (1) DD228257A5 (en)
DE (2) DE3422844A1 (en)
DK (1) DK307184A (en)
ES (1) ES533654A0 (en)
HK (1) HK91592A (en)
HU (1) HUT37620A (en)
IE (1) IE58012B1 (en)
IL (1) IL72208A (en)
NZ (1) NZ208554A (en)
PH (1) PH21523A (en)
ZA (1) ZA844776B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
DE19975048I2 (en) * 1985-05-13 2001-06-13 American Cyanamid Co 7- (3-disubstituted amino) phenyl pyrazolo 1,5-a-pyrimidine
JPS61223072A (en) * 1986-02-21 1986-10-03 Canon Inc Ink-jet recording method
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
US4847256A (en) * 1986-10-16 1989-07-11 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
FI864570A0 (en) * 1986-11-11 1986-11-11 Farmos Oy THERAPEUTIC ANVAENDBAR FOERENING.
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
HUP0202698A3 (en) * 1999-09-02 2004-12-28 Neurocrine Biosciences Inc Polymorphs of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
WO2004110454A1 (en) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. COMPOSITION FOR TREATMENT FOR OR PREVENTION OF DISEASE NECESSITATING ADMINISTRATION OF ADENOSINE A2a RECEPTOR AGONIST
ES2222813B1 (en) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N- (3- (3-SUBSTITUTES-PIRAZOLO (1,5-A) PIRIMIDIN-7-IL) -PENYL) -SULPHONAMIDS AND RELATED COMPOSITIONS AND METHODS
ES2222814B1 (en) * 2003-07-24 2005-12-01 Ferrer Internacional, S.A. 3-NITRO-PIRAZOLO (1,5-A) PYRIMIDINS 7-REPLACED AND RELATED COMPOSITIONS AND METHODS.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (en) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp NEW PYRAZOLO (1.5A) PYRIMIDINES AND THEIR PREPARATION PROCESS
US4093617A (en) * 1974-11-12 1978-06-06 Icn Pharmaceuticals, Inc. 3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
ZA803591B (en) * 1979-07-09 1981-06-24 American Cyanamid Co Substituted pyrazolo(1,5-a)pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents

Also Published As

Publication number Publication date
IE58012B1 (en) 1993-06-16
IL72208A (en) 1987-11-30
AU2977084A (en) 1985-01-03
AU568656B2 (en) 1988-01-07
CA1233174A (en) 1988-02-23
NZ208554A (en) 1987-06-30
DK307184A (en) 1984-12-24
JPS6019788A (en) 1985-01-31
KR900001886B1 (en) 1990-03-26
ZA844776B (en) 1985-02-27
EP0129847A2 (en) 1985-01-02
ATE53391T1 (en) 1990-06-15
PH21523A (en) 1987-11-16
EP0129847B1 (en) 1990-06-06
HK91592A (en) 1992-11-27
ES8505958A1 (en) 1985-07-01
DE3422844A1 (en) 1985-01-17
DE3482419D1 (en) 1990-07-12
ES533654A0 (en) 1985-07-01
KR850000443A (en) 1985-02-27
JPH0531551B2 (en) 1993-05-12
IE841580L (en) 1984-12-23
IL72208A0 (en) 1984-10-31
EP0129847A3 (en) 1987-05-20
DD228257A5 (en) 1985-10-09
DK307184D0 (en) 1984-06-22

Similar Documents

Publication Publication Date Title
GB2196627B (en) Intermediate 1,2,4-triazolo 1,5-a pyrimidine-2-sulfonyl chloridess
HUT37620A (en) Process for production of derivatives of aril or heteroane-/7-aril or heteroane/-pirasolo/1,5-a/-pirimidin-3-il/-methanon and medical preparatives containing such compounds
MY104861A (en) Bis-aza-bicyclic anxiolytic agents.
HU182153B (en) Process for preparing substituted pyrazolo/1,5-a/pyrimidine derivatives
PH21579A (en) (3-amino-1h-pyrazol-4-yl) (aryl) methanones and process for the preparation of the same
IL73495A0 (en) Method of preparing 1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonyl chlorides
DK231686D0 (en) OXADIAZOLYLIMIDAZOBENZODIAZEPINE COMPOUND, PHARMACEUTICAL PREPARATION CONTAINING SAME, PROCEDURE FOR PREPARING THE COMPOUND AND PROCEDURE FOR TREATING A CENTRAL SYSTEM SYSTEM
PL244194A1 (en) Process for preparing novel derivatives of /1,2,4/triazolo/4,3-a/quinoxaline
GB2016002B (en) Amino derivatives of pyrazolo(1,5-a)s triazine
FI830949L (en) FRAME FOR SUSPENSION OF 1H-PYRAZOLO / 1,5-A / PYRIMIDINE
IL78791A (en) 7-substituted-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-4h-imidazo(1,5-a)-(1,4)-benzodiazepines,pharmaceutical compositions containing them and method of preparing them
CY2003B1 (en) Anticonvulsant triazolo(4,5-C) pyridine derivatives
CA2171003A1 (en) Process for preparing n-(2,6-dichloro-3-methylphenyl)-5-7-dihalo[1,2,4]triazolo[1,5a]pyrimidine-2-sulfonamide by cyclization and halo-dehydroxylation
ATA416882A (en) METHOD FOR PRODUCING NEW SPIRO DERIVATIVES OF THE PYRAZOLO (1,5-D) (1,2,4) TRIAZINE RING SYSTEM
DE3266879D1 (en) Production of 4-chloro-7-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)-7h-pyrrolo(2,3-d) pyrimidine compounds
HU910067D0 (en) Process for the production of 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo (1.5-a)pyrimidines