HUP9904259A2 - Process for producing solid dosage forms - Google Patents

Process for producing solid dosage forms

Info

Publication number
HUP9904259A2
HUP9904259A2 HU9904259A HUP9904259A HUP9904259A2 HU P9904259 A2 HUP9904259 A2 HU P9904259A2 HU 9904259 A HU9904259 A HU 9904259A HU P9904259 A HUP9904259 A HU P9904259A HU P9904259 A2 HUP9904259 A2 HU P9904259A2
Authority
HU
Hungary
Prior art keywords
polymer
binder
mixture
dosage forms
solid dosage
Prior art date
Application number
HU9904259A
Other languages
Hungarian (hu)
Inventor
Jörg Breitenbach
Andreas Kleinke
Stephan Kothrade
Joerg Rosenberg
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of HUP9904259A2 publication Critical patent/HUP9904259A2/en
Publication of HUP9904259A3 publication Critical patent/HUP9904259A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Abstract

A találmány tárgya szilárd adagőlási főrmák előállítására szőlgálóeljárás, amelynél 50 és 99,9 tömeg% közötti mennyiségben összekevernekegy pőlimer kötőanyagőt, legalább egy hatóanyag-kőmpőnenst és adőttesetben szőkásős adalékanyagőkat, a keveréket extrűdálják, ahől apőlimer kötőanyagnak legalább egy részét vizes diszperzió alakjábanalkalmazzák, a diszpergálószert az extrűderben elpárőlőgtatják, és akeveréket főrmázzák. A pőlimer kötőanyagőt a pőli(met)akrilátők ésazőknak a (met)akrilsavval pőli(vinil-laktámők)-kal, pőli(vinil-észterek)-kel képezett kőpőlimerjei, valamint az N-vinil-laktámőknakés vinil-észtereknek kőpőlimerjei közül választják; a kötőanyagnaklegalább egy részét vizes diszperzió vagy önmagában, vagyahatóanyagnak és/vagy az adalékanyagőknak legalább egy részévelalkőtőtt keverék pőlimer őlvadékaként alkalmazzák. A hatóanyag-kőmpőnenst vizes őldat vagy vízzel elegyedő szerves őldószeres,különösen 1-4 szénatőmős alkanőlős őldat alakjában alkalmazzák, éslegalább egy részét az extrúziós eljárás közben keverik be. ŕThe subject of the invention is a kneading process for the production of solid dosage forms, in which a polymer binder is mixed in an amount of between 50 and 99.9% by weight, at least one active ingredient, and bleaching additives in the bulk, the mixture is extruded, from which at least a part of the parent polymer binder is used in the form of an aqueous dispersion, the dispersant is it is evaporated in an extruder and the mixture is boiled. The polymer binder is selected from the polymer (meth)acrylate binders, the polymer resins formed with (meth)acrylic acid with vinyl lactams, vinyl esters, and N-vinyl lactams and vinyl esters; at least a part of the binder is used as an aqueous dispersion or as a polymer melt on its own, or as a polymer melt of a mixture made up of at least a part of the active material and/or the additives. The active ingredient limestone is used in the form of an aqueous solution or a water-miscible organic solvent, especially a solution with 1-4 carbon atoms, and at least a part of it is mixed in during the extrusion process. ŕ

HU9904259A 1997-08-06 1997-09-11 Process for producing solid dosage forms HUP9904259A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19734011A DE19734011A1 (en) 1997-08-06 1997-08-06 Preparation of solid dosage forms with polymeric binder

Publications (2)

Publication Number Publication Date
HUP9904259A2 true HUP9904259A2 (en) 2000-04-28
HUP9904259A3 HUP9904259A3 (en) 2000-05-29

Family

ID=7838148

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904259A HUP9904259A3 (en) 1997-08-06 1997-09-11 Process for producing solid dosage forms

Country Status (2)

Country Link
DE (1) DE19734011A1 (en)
HU (1) HUP9904259A3 (en)

Also Published As

Publication number Publication date
HUP9904259A3 (en) 2000-05-29
DE19734011A1 (en) 1999-02-11

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