HUP9904227A2 - Use of macrocyclic 3,4-bis(3,3'-indolyl)pyrroline-2,5-dione derivatives for the manufacture of pharmaceutical compositions treating htlv-1 infections - Google Patents

Use of macrocyclic 3,4-bis(3,3'-indolyl)pyrroline-2,5-dione derivatives for the manufacture of pharmaceutical compositions treating htlv-1 infections

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Publication number
HUP9904227A2
HUP9904227A2 HU9904227A HUP9904227A HUP9904227A2 HU P9904227 A2 HUP9904227 A2 HU P9904227A2 HU 9904227 A HU9904227 A HU 9904227A HU P9904227 A HUP9904227 A HU P9904227A HU P9904227 A2 HUP9904227 A2 HU P9904227A2
Authority
HU
Hungary
Prior art keywords
cell
pyrroline
macrocyclic
indolyl
infections
Prior art date
Application number
HU9904227A
Other languages
Hungarian (hu)
Inventor
Michael R. Jirousek
Lawrence E. Stramm
Douglas K. Ways
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/917,517 external-priority patent/US5962446A/en
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9904227A2 publication Critical patent/HUP9904227A2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Inhibiting human T cell lymphotrophic virus type I replication in an infected cell comprises contacting the cell with an inhibitor of the ~b-isozyme of protein kinase C (PKC). Also claimed are inhibiting the effects of Tax 1 viral protein activity in a cell, treating human T cell lymphotropic virus (HTLV) type 1 and adult T cell leukaemia or a chronic neurodegenerative disorder associated with HTLV infection, comprising contacting the cell with an inhibitor of the ~b-isozyme of PKC.
HU9904227A 1997-08-26 1997-08-28 Use of macrocyclic 3,4-bis(3,3'-indolyl)pyrroline-2,5-dione derivatives for the manufacture of pharmaceutical compositions treating htlv-1 infections HUP9904227A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/917,517 US5962446A (en) 1996-08-30 1997-08-26 Therapetutic treatment for human T cell lymphotrophic virus type 1 infection

Publications (1)

Publication Number Publication Date
HUP9904227A2 true HUP9904227A2 (en) 2000-05-28

Family

ID=25438902

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904227A HUP9904227A2 (en) 1997-08-26 1997-08-28 Use of macrocyclic 3,4-bis(3,3'-indolyl)pyrroline-2,5-dione derivatives for the manufacture of pharmaceutical compositions treating htlv-1 infections

Country Status (1)

Country Link
HU (1) HUP9904227A2 (en)

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