HUP9904108A2 - Process for the preparation of nizatidine - Google Patents

Process for the preparation of nizatidine

Info

Publication number
HUP9904108A2
HUP9904108A2 HU9904108A HUP9904108A HUP9904108A2 HU P9904108 A2 HUP9904108 A2 HU P9904108A2 HU 9904108 A HU9904108 A HU 9904108A HU P9904108 A HUP9904108 A HU P9904108A HU P9904108 A2 HUP9904108 A2 HU P9904108A2
Authority
HU
Hungary
Prior art keywords
methyl
formula
nizatidine
preparation
salt
Prior art date
Application number
HU9904108A
Other languages
Hungarian (hu)
Inventor
Philip Cornwall
Original Assignee
Knoll Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Aktiengesellschaft filed Critical Knoll Aktiengesellschaft
Publication of HUP9904108A2 publication Critical patent/HUP9904108A2/en
Publication of HUP9904108A3 publication Critical patent/HUP9904108A3/en

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation of nizatidine, i.e. N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, of formula (I) (or its salt) involves reaction of 2-nitromethylene-imidazolidine of formula (II) with a 4-(substituted methyl)-2-dimethylaminomethyl-imidazole of formula (III) (or its salt) in the presence of methylamine and an inert diluent. X = leaving group, preferably halo, mesyloxy or tosyloxy.
HU9904108A 1997-05-17 1997-08-29 Process for the preparation of nizatidine HUP9904108A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9710005.1A GB9710005D0 (en) 1997-05-17 1997-05-17 Chemical process

Publications (2)

Publication Number Publication Date
HUP9904108A2 true HUP9904108A2 (en) 2000-05-28
HUP9904108A3 HUP9904108A3 (en) 2001-11-28

Family

ID=10812457

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904108A HUP9904108A3 (en) 1997-05-17 1997-08-29 Process for the preparation of nizatidine

Country Status (2)

Country Link
GB (1) GB9710005D0 (en)
HU (1) HUP9904108A3 (en)

Also Published As

Publication number Publication date
GB9710005D0 (en) 1997-07-09
HUP9904108A3 (en) 2001-11-28

Similar Documents

Publication Publication Date Title
DK271287A (en) TRANS-6- (2- (3- OR 4-CARBOXAMIDO-SUBSTITUTED PYRROL-1-YL) ALKYL) -4-HYDROXYPYRAN-2-ONES, THEIR PREPARATION AND PHARMACEUTICAL USE
PL300235A1 (en) 5-{2-[4-(1,2-benzoisothiazolyl-3)-1-piperozinyl] ethyl}-6-chloro-1,3-dihydro-2h-indolone-2 hydrochloride monohydrate
PL323780A1 (en) Substituted compounds: (sulphinic, sulphonic, sylphonylaamino sulphinylamino) n-[(aminoiminomethyl)-phenylalkyl]-azaheterocyclic amides
HK1008328A1 (en) Endothelin antagonists
NO965084D0 (en) N- [3- (3-cyanopyrazolo [1,5-aÅpyrimidin-7-yl) fenylÅ -N-ethyl-acetamide
SG44989A1 (en) Crystalline hydrochloride of (R)-(-)-2-{N-[4-(1,1-dioxid-3-oxo-2,3-dihydro-benzisothiazol-2-yl)-butyl]-aminomethyl}-chroman
WO1988004657A3 (en) TRANS-6-[2-[2-(SUBSTITUTED-PHENYL)-3- (or 4-) HETEROARYL-5-SUBSTITUTED-1H-PYRROL-1-YL]-ETHYL]TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONE INHIBITORS OF CHOLESTEROL BIOSYNTHESIS
CA2085802A1 (en) 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds useful for the preparation of 5-(substituted methyl) -2,3-pyridinedicarboxylic acids
EP1609790A3 (en) Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
GB9718903D0 (en) Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CA2288637A1 (en) Process for the preparation of 2-[(2-thienyl)-ethylamino-(2-halogenophe nyl)-acetonitriles
DK1026170T3 (en) Erythromycin derivatives, processes for their preparation and their use as drugs
BR9100221A (en) COMPOUND; METHOD FOR TREATING HYPERTENSION, CONGESTIVE HEART FAILURE OR GLAUCOMA IN A MAMMALIAN; AND PHARMACEUTICAL COMPOSITION
HUP9904108A2 (en) Process for the preparation of nizatidine
EG24052A (en) Novel processes for the preparation of (r)-a (2,3-demethoxyphenyl-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethapnol
ZA200002514B (en) Process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine.
NZ334460A (en) Process for the preparation of nizatidine
AU690381B2 (en) Method for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted) benzene compounds
WO1989008098A3 (en) Lipophilic polyamines useful for treating hypercholesterolemia
MY130559A (en) Process for the manufacture of form 1 ranitidine hydrochloride
GR3035215T3 (en) Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole
EP1116720A4 (en) Processes for the preparation of isochromanones and intermediates for the preparation thereof
CA2198536A1 (en) Method of reducing tissue damage associated with ischemia
ES497737A0 (en) PROCEDURE FOR OBTAINING N- (2 - ((5 - ((DIMETHYLAMI-NO) METHYL) FURFURIL) THIO) ETHYL) -N'- METHYL -2- NITRO-1,1- ETHENO- DIAMINE
TR200200949T2 (en) Polymorphic N- [3 - [[2- (3,4-dimethoxyphenyl) ethyl] amino] propyl] -4-nitro benzamide hydrochloride