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Publication of HUP9904108A2publicationCriticalpatent/HUP9904108A2/en
Publication of HUP9904108A3publicationCriticalpatent/HUP9904108A3/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Preparation of nizatidine, i.e. N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, of formula (I) (or its salt) involves reaction of 2-nitromethylene-imidazolidine of formula (II) with a 4-(substituted methyl)-2-dimethylaminomethyl-imidazole of formula (III) (or its salt) in the presence of methylamine and an inert diluent. X = leaving group, preferably halo, mesyloxy or tosyloxy.
HU9904108A1997-05-171997-08-29Process for the preparation of nizatidine
HUP9904108A3
(en)