HUP9903016A2 - Improved process for synthesizing carbapenem intermediates - Google Patents

Improved process for synthesizing carbapenem intermediates

Info

Publication number
HUP9903016A2
HUP9903016A2 HU9903016A HUP9903016A HUP9903016A2 HU P9903016 A2 HUP9903016 A2 HU P9903016A2 HU 9903016 A HU9903016 A HU 9903016A HU P9903016 A HUP9903016 A HU P9903016A HU P9903016 A2 HUP9903016 A2 HU P9903016A2
Authority
HU
Hungary
Prior art keywords
formula
improved process
carbapenem intermediates
synthesizing carbapenem
compound
Prior art date
Application number
HU9903016A
Other languages
Hungarian (hu)
Inventor
Chunhua Yang
Nobuyoshi Yasuda
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of HUP9903016A2 publication Critical patent/HUP9903016A2/en
Publication of HUP9903016A3 publication Critical patent/HUP9903016A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Abstract

A találmány tárgya eljárás az (1) vagy (2) általánős képletűvegyületek - a képletben R jelentése hidrőgénatőm vagy metilcsőpőrt ésP jelentése trimetil- vagy trietil-szililcsőpőrt - előállítására. Atalálmány értelmében úgy járnak el, hőgy a (3) vagy (4) képletűvegyületet valamely P-Cl általánős képletű vegyületettel - a képletbenP jelentése a kőrábban megadőtt - reagáltatják egy bázis és egy, areaktánsőkkal szemben lényegében közömbös őldószer jelenlétében. ŕThe subject of the invention is a process for the production of the compounds of the general formula (1) or (2) - in the formula, R represents a hydrogen atom or methyl pipe powder and P represents trimethyl or triethylsilyl pipe powder. According to the invention, they proceed by reacting the compound of formula (3) or (4) with a compound of the formula P-Cl - in the formula P is the value given in the formula - in the presence of a base and a solvent essentially indifferent to reactants. ŕ

HU9903016A 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates HUP9903016A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates
PCT/US1996/010783 WO1997001564A1 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Publications (2)

Publication Number Publication Date
HUP9903016A2 true HUP9903016A2 (en) 2000-03-28
HUP9903016A3 HUP9903016A3 (en) 2000-04-28

Family

ID=26308678

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903016A HUP9903016A3 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Country Status (13)

Country Link
EP (1) EP0836607A1 (en)
JP (1) JPH11513979A (en)
KR (1) KR19990028406A (en)
CN (1) CN1193322A (en)
AR (1) AR002507A1 (en)
AU (1) AU696543B2 (en)
BR (1) BR9609338A (en)
CA (1) CA2224439A1 (en)
CZ (1) CZ419097A3 (en)
EA (1) EA199800096A1 (en)
HU (1) HUP9903016A3 (en)
SK (1) SK176597A3 (en)
WO (1) WO1997001564A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009277936B2 (en) 2008-07-30 2014-11-27 Sun Pharmaceutical Industries Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
JP2675625B2 (en) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 Method for producing enol silyl ether compound
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE3934100A1 (en) * 1989-10-12 1991-04-18 Bayer Ag METHOD FOR PRODUCING 0-SILYLATED HYDROXYL COMPOUNDS AND THE USE THEREOF FOR PRODUCING ISOCYANATES HAVING ESTER GROUPS

Also Published As

Publication number Publication date
HUP9903016A3 (en) 2000-04-28
EA199800096A1 (en) 1998-08-27
SK176597A3 (en) 1998-07-08
CZ419097A3 (en) 1998-07-15
BR9609338A (en) 1999-05-11
CN1193322A (en) 1998-09-16
WO1997001564A1 (en) 1997-01-16
AU6392196A (en) 1997-01-30
AR002507A1 (en) 1998-03-25
JPH11513979A (en) 1999-11-30
MX9800041A (en) 1998-08-30
KR19990028406A (en) 1999-04-15
AU696543B2 (en) 1998-09-10
EP0836607A1 (en) 1998-04-22
CA2224439A1 (en) 1997-01-16

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