HUP9902678A2 - Halo-substituted bis-indolemaleimid protein kinase c inhibitors and pharmaceutical compositions containing them - Google Patents
Halo-substituted bis-indolemaleimid protein kinase c inhibitors and pharmaceutical compositions containing themInfo
- Publication number
- HUP9902678A2 HUP9902678A2 HU9902678A HUP9902678A HUP9902678A2 HU P9902678 A2 HUP9902678 A2 HU P9902678A2 HU 9902678 A HU9902678 A HU 9902678A HU P9902678 A HUP9902678 A HU P9902678A HU P9902678 A2 HUP9902678 A2 HU P9902678A2
- Authority
- HU
- Hungary
- Prior art keywords
- halo
- indolemaleimid
- inhibitors
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 229940123924 Protein kinase C inhibitor Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003881 protein kinase C inhibitor Substances 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 10
- 125000001589 carboacyl group Chemical group 0.000 abstract 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Indole derivatives of formula (I) are new. R' = H, halo, OH, Q, QO, NR3R4 or NHCOQ; V = O, NH or NQ; T = 1-4C alkylene (optionally substituted by halo or Q); W = 1-2C alkylene (optionally substituted by halo or Q); J = X-C(Y)(S') or, when, T and W are both methylene, a group of formula -(CH2)nCH2C(CH2NR3R4)=C(halo)- (i), -(CH2)nC(halo)=C(CH2NR3R4)(CH2)m- (ii) or -C(halo)=CHCH(CH2NR3R4)(CH2)n- (iii); n, m = 1 or 2; X = O, S or a bond; Y = halo, Q or H; S' = CHO or C(Z)(R2)(M); M = H, CH2OR5, CH2NR3R4 or NR3R4; R2 = H or halo; Z = H or OR6; R3, R4 = H, Q, halo-Q, 1-4C alkanoyl or halo(1-4C alkanoyl); or NR3R4 = a 5-6 membered ring; R5, R6 = H, Q, halo-Q, 1-4C alkanoyl or halo(1-4C alkanoyl); or R5+R6 = a divalent group of formula CR7R8; R7, R8 = H, Q or halo-Q; or CR7R8 = a 5-6 membered ring; Q = 1-4C alkyl; provided that at least one of Y, S', T and W = halo or a halo-substituted group, or T and W are both methylene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902678A HUP9902678A3 (en) | 1997-04-30 | 1997-04-30 | Halo-substituted bis-indolemaleimid protein kinase c inhibitors and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902678A HUP9902678A3 (en) | 1997-04-30 | 1997-04-30 | Halo-substituted bis-indolemaleimid protein kinase c inhibitors and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9902678A2 true HUP9902678A2 (en) | 1999-12-28 |
| HUP9902678A3 HUP9902678A3 (en) | 2000-02-28 |
Family
ID=90001706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902678A HUP9902678A3 (en) | 1997-04-30 | 1997-04-30 | Halo-substituted bis-indolemaleimid protein kinase c inhibitors and pharmaceutical compositions containing them |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9902678A3 (en) |
-
1997
- 1997-04-30 HU HU9902678A patent/HUP9902678A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9902678A3 (en) | 2000-02-28 |
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