HUP9902452A1 - Probe for analysis of nucleic acids - Google Patents

Probe for analysis of nucleic acids

Info

Publication number
HUP9902452A1
HUP9902452A1 HU9902452A HUP9902452A HUP9902452A1 HU P9902452 A1 HUP9902452 A1 HU P9902452A1 HU 9902452 A HU9902452 A HU 9902452A HU P9902452 A HUP9902452 A HU P9902452A HU P9902452 A1 HUP9902452 A1 HU P9902452A1
Authority
HU
Hungary
Prior art keywords
probe
sre
binding
nucleic acid
analysis
Prior art date
Application number
HU9902452A
Other languages
Hungarian (hu)
Inventor
Mikael Kubista
Nicke Svanvik
Original Assignee
Mikael Kubista
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mikael Kubista filed Critical Mikael Kubista
Priority to HU9902452A priority Critical patent/HUP9902452A3/en
Publication of HUP9902452A1 publication Critical patent/HUP9902452A1/en
Publication of HUP9902452A3 publication Critical patent/HUP9902452A3/en

Links

Abstract

A probe for target nucleic acid sequences comprises a sequence recognising element (SRE) covalently bound to a reporter group (RG) whose signal properties are considerably altered when it binds to nucleic acid (NA). The probe (i) at least in its part nearest to the RG, has a structure such that any intramolecular interaction between the SRE and RG is suppressed, or such that this intramolecular interaction minimally affects the signal properties, and/or (ii) upon binding to target sequences, creates a structure that increases the signal alteration caused by the binding of the RG to NA. Also claimed are three specific groups of asymmetric cyanine compounds which can be used as reporter groups in the above probe.
HU9902452A 1997-05-30 1997-05-30 Probe for analysis of nucleic acids HUP9902452A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9902452A HUP9902452A3 (en) 1997-05-30 1997-05-30 Probe for analysis of nucleic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902452A HUP9902452A3 (en) 1997-05-30 1997-05-30 Probe for analysis of nucleic acids

Publications (2)

Publication Number Publication Date
HUP9902452A1 true HUP9902452A1 (en) 2000-02-28
HUP9902452A3 HUP9902452A3 (en) 2001-04-28

Family

ID=89998807

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902452A HUP9902452A3 (en) 1997-05-30 1997-05-30 Probe for analysis of nucleic acids

Country Status (1)

Country Link
HU (1) HUP9902452A3 (en)

Also Published As

Publication number Publication date
HUP9902452A3 (en) 2001-04-28

Similar Documents

Publication Publication Date Title
RU2223966C2 (en) Probe for analysis of nucleic acids
DE69432419D1 (en) AN ELECTROCHEMILUMINESCENT DETECTION OF NUCLEIC ACIDS BASED ON THE SELF-SUPPORTING SEQUENCE REPLICATION
ATE425175T1 (en) METHODS AND COMPOSITIONS FOR DETERMINING SEQUENCES OF NUCLEIC ACID MOLECULES
CA2252817A1 (en) Improved probing of specific nucleic acids
FI935208A0 (en) Evaluation of nucleic acid analogues and diagnostic and analytical procedures
WO2001088197A3 (en) Methods and compositions for interaction trap assays
CA2020958A1 (en) Nucleic acid sequence amplification methods
WO1998002582A3 (en) Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
DE69431485D1 (en) DOUBLE-STRANDED PEPTIDE NUCLEIC ACIDS
DE69836885D1 (en) Detection of nucleic acids by fluorescence quenching
ATE146530T1 (en) SIGNAL AMPLIFICATION OF A DNS PROBE
WO1999064592A3 (en) Green fluorescent proteins for measuring the ph of a biological sample
WO1996017955A3 (en) Discontinuous probe design using hybritope mapping
CA2111853A1 (en) Substantially pure receptor like tgf-.beta.1 binding molecules and uses thereof
WO2002090987A3 (en) Universal fluorescent sensors
ES2150103T3 (en) NUCLEIC ACID AMPLIFICATION OLIGONUCLEOTIDES AND BORRELIA PROBES ASSOCIATED WITH LYME DISEASE.
EP0579771A4 (en) Single-stranded circular oligonucleotides
DE60039772D1 (en) METHOD FOR AMPLIFYING SIGNAL FLANKING
DE69821376D1 (en) PROCESS FOLD-BACK PROCESS USING LOW MOLECULAR WEIGHT INTERMEDIATE ACTIVE SUBSTANCES
DK1238284T3 (en) Diagnostic determination of stroke
WO1998011226A3 (en) Mammalian chemokines, related reagents
DE69815370D1 (en) FLUORESCEND CONJUGATES OF NUCLEOSIDES AND NUCLEOTIDES, THEIR METHOD FOR THE PRODUCTION AND THEIR USE
EP1106621A3 (en) Fluorescent substances
DE69619410D1 (en) COMPOSITIONS FOR NUCLEIC ACID TARGET DIRECTION
DE59812184D1 (en) METHOD FOR IDENTIFYING NUCLEIC ACIDS BY ELECTROSPRAY MASS SPECTROMETRY

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees