HUP9901892A2 - Eljárás aril- és vinil-nitril vegyületek előállítására - Google Patents

Eljárás aril- és vinil-nitril vegyületek előállítására

Info

Publication number
HUP9901892A2
HUP9901892A2 HU9901892A HUP9901892A HUP9901892A2 HU P9901892 A2 HUP9901892 A2 HU P9901892A2 HU 9901892 A HU9901892 A HU 9901892A HU P9901892 A HUP9901892 A HU P9901892A HU P9901892 A2 HUP9901892 A2 HU P9901892A2
Authority
HU
Hungary
Prior art keywords
atom
ion
carbon atom
aryl
preparation
Prior art date
Application number
HU9901892A
Other languages
English (en)
Inventor
Benjamin A. Anderson
Lisa M. Becke
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9901892A2 publication Critical patent/HUP9901892A2/hu
Publication of HUP9901892A3 publication Critical patent/HUP9901892A3/hu
Publication of HU222766B1 publication Critical patent/HU222766B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

A találmány tárgya eljárás aril- és vinil-nitril-vegyületekelőállítására. A találmány szerinti úgy járnak el, hőgy az R-X R-CNreakciót hajtják végre, amelynek sőrán a szűbsztrátőt, amely az R-Xáltalánős képletű vegyület, valamely cianidiőn-főrrással, valamelypalládiűm(0)-katalizátőrral és katalitikűs mennyiségű valamely fémiőn-főrrással reagáltatják, amely fémiőnfőrrás réz(I)iőn, réz(II)iőn vagycink(II)iőn, alkalmas őldószerben, az általánős képletben R jelentéseőlyan csőpőrt, ahől egy első sp2-hibridizált szénatőm található, majdez kettős kötéssel kapcsőlódik egy másődik sp2-hibridizált atőmmal,amely lehet szénatőm vagy nitrőgénatőm, és az első sp2-hibridizáltszénatőm X szűbsztitűenst tartalmaz, amely lehet jódatőm, brómatőmvagy triflűőr-metánszűlfőnil-őxi-csőpőrt. A találmány szerinti eljárásőlyan anyagők előállítására alkalmazható, amelyek gyógyszerészetbenközbenső termékként felhasznál- hatók. ŕ
HU9901892A 1995-10-31 1996-10-21 Eljárás aril- és vinil-nitril vegyületek előállítására HU222766B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US817995P 1995-10-31 1995-10-31
PCT/US1996/016802 WO1997016414A1 (en) 1995-10-31 1996-10-21 Preparation of aryl and vinyl nitriles

Publications (3)

Publication Number Publication Date
HUP9901892A2 true HUP9901892A2 (hu) 1999-09-28
HUP9901892A3 HUP9901892A3 (en) 2001-07-30
HU222766B1 HU222766B1 (hu) 2003-10-28

Family

ID=21730185

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901892A HU222766B1 (hu) 1995-10-31 1996-10-21 Eljárás aril- és vinil-nitril vegyületek előállítására

Country Status (15)

Country Link
EP (1) EP0771786B1 (hu)
JP (1) JPH11514647A (hu)
KR (1) KR19990067145A (hu)
AT (1) ATE189808T1 (hu)
AU (1) AU7459396A (hu)
BR (1) BR9611341A (hu)
CA (1) CA2235989C (hu)
DE (1) DE69606679T2 (hu)
DK (1) DK0771786T3 (hu)
ES (1) ES2142028T3 (hu)
GR (1) GR3033366T3 (hu)
HU (1) HU222766B1 (hu)
IL (1) IL124241A (hu)
PT (1) PT771786E (hu)
WO (1) WO1997016414A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG74666A1 (en) 1997-10-21 2000-08-22 Givaudan Roure Int Beta-ketoester
WO2007089193A1 (en) * 2006-02-02 2007-08-09 Astrazeneca Ab A process for preparing 2-hydroxy-3- [5- (morpholin-4-ylmethyl)pyridin-2-yl] lh-indole-5-carbonitrile as a free base or salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211721A (en) * 1978-12-04 1980-07-08 Hooker Chemicals & Plastics Corp. Process for the preparation of aromatic nitriles
JPS55120549A (en) * 1979-03-09 1980-09-17 Nippon Kayaku Co Ltd Preparation of 2-chloro-6-nitrobenzonitrile
EP0097357B1 (en) * 1982-06-23 1986-01-08 Daikin Kogyo Co., Ltd. Process for preparing trifluoromethylbenzene derivatives
US4886936A (en) * 1988-08-15 1989-12-12 Ici Americas Inc. Process for the production of ortho-nitrobenzonitriles

Also Published As

Publication number Publication date
IL124241A (en) 2003-05-29
JPH11514647A (ja) 1999-12-14
MX9803383A (es) 1998-09-30
WO1997016414A1 (en) 1997-05-09
DE69606679D1 (de) 2000-03-23
DE69606679T2 (de) 2000-06-29
KR19990067145A (ko) 1999-08-16
GR3033366T3 (en) 2000-09-29
AU7459396A (en) 1997-05-22
EP0771786A1 (en) 1997-05-07
ES2142028T3 (es) 2000-04-01
EP0771786B1 (en) 2000-02-16
CA2235989A1 (en) 1997-05-09
BR9611341A (pt) 1999-07-13
PT771786E (pt) 2000-07-31
CA2235989C (en) 2004-08-03
DK0771786T3 (da) 2000-06-05
HUP9901892A3 (en) 2001-07-30
HU222766B1 (hu) 2003-10-28
ATE189808T1 (de) 2000-03-15

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030901

MM4A Lapse of definitive patent protection due to non-payment of fees