HUP9901672A2 - Method for treatment of cancer and infectious diseases and compositions useful in same - Google Patents
Method for treatment of cancer and infectious diseases and compositions useful in sameInfo
- Publication number
- HUP9901672A2 HUP9901672A2 HU9901672A HUP9901672A HUP9901672A2 HU P9901672 A2 HUP9901672 A2 HU P9901672A2 HU 9901672 A HU9901672 A HU 9901672A HU P9901672 A HUP9901672 A HU P9901672A HU P9901672 A2 HUP9901672 A2 HU P9901672A2
- Authority
- HU
- Hungary
- Prior art keywords
- subject
- hsp
- target
- cells
- stimulating
- Prior art date
Links
- 208000035473 Communicable disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 6
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 6
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 3
- 230000004936 stimulating effect Effects 0.000 abstract 3
- 230000001086 cytosolic effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A method for stimulating a therapeutic immune response in a subject comprising introducing to the subject or to a target gp. of cells from the subject, an expressible polynucleotide encoding a eukaryotic heat shock protein (HSP) is claimed. Also claimed are: (1) a method for stimulating a prophylactic immune response against recurrence of a disease from which a subject is suffering,comprising administering to the subject or to a target gp. of cells from the subject harbouring an antigen associated with the disease, an expressible polynucleotide encoding a eukaryotic HSP; (2) a recombinant vector comprising: (a) a promoter system effective to promote expression of the vector in mammalian cells; and (b) a region encoding a cytosolic HSP to which an amino terminal signal sequence effective to promote uptake of the expressed cytosolic HSP by the endoplasmic reticulum has been added; (3) a method for stimulating an immune response to an antigen present in a target gp. of mammalian cells, comprising administering to the target gp. an expressible polynucleotide, where expression of the polynucleotide is effective to increase the amt. of antigen-associated HSP present in the cells.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US247995P | 1995-08-18 | 1995-08-18 | |
| US248095P | 1995-08-18 | 1995-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901672A2 true HUP9901672A2 (en) | 1999-09-28 |
| HUP9901672A3 HUP9901672A3 (en) | 2000-10-30 |
Family
ID=26670442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901672A HUP9901672A3 (en) | 1995-08-18 | 1996-08-16 | Method for treatment of cancer and infectious diseases and compositions useful in same |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9901672A3 (en) |
-
1996
- 1996-08-16 HU HU9901672A patent/HUP9901672A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901672A3 (en) | 2000-10-30 |
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