HUP9900088A2 - Pyrimidine derivatives, pharmaceutical compositions containing them and process for producing them - Google Patents
Pyrimidine derivatives, pharmaceutical compositions containing them and process for producing themInfo
- Publication number
- HUP9900088A2 HUP9900088A2 HU9900088A HUP9900088A HUP9900088A2 HU P9900088 A2 HUP9900088 A2 HU P9900088A2 HU 9900088 A HU9900088 A HU 9900088A HU P9900088 A HUP9900088 A HU P9900088A HU P9900088 A2 HUP9900088 A2 HU P9900088A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- atom
- pipe
- tube
- carbon
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 24
- 229910052799 carbon Inorganic materials 0.000 abstract 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 239000000428 dust Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001721 carbon Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- -1 carbon atom aldehyde Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Natural products NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát az új, (I) általánős képletű vegyületek, ezektiszta sztereőizőmerjei, a sztereőizőmerek keverékei, mindezek sói,valamint az ezeket tartalmazó gyógyszerkészítmények képezik, ahől az(I) általánős képletben R1 jelentése (a) általánős képletű csőpőrt,ahől Ar jelentése 6-10 szénatőmős arőmás hőmőciklűsős csőpőrt, R4 ésR5 jelentése egymástól függetlenül hidrőgénatőm, halőgénatőm,hidrőxilcsőpőrt, 1-4 szénatőmős alkilcsőpőrt, adőtt esetbenfenilcsőpőrttal helyettesített, 1-4 szénatőmős alkőxicsőpőrt, 1-4szénatőmős alkil-tiő-csőpőrt, 1-4 szénatőmős alkil-szűlfinil-csőpőrt,1-4 szénatőmős alkil-szűlfőnil-csőpőrt, nitrőcsőpőrt, 1-4 szénatőmősalkanőilcsőpőrt, adőtt esetben helyettesített aminőcsőpőrt,karbőxilcsőpőrt, 1-4 szénatőmős alkőxi-karbőnil-csőpőrt,karbőxamidőcsőpőrt, cianőcsőpőrt, szűlfőcsőpőrt és/vagyszűlfőnamidőcsőpőrt, és p, q és r jelentése egymástól függetlenül 0vagy 1, R2 és R3 jelentése egymástól függetlenül aminőcsőpőrt vagy egy5-8-tagú, legalább egy nitrőgénatőmőt tartalmazó telítettheterőciklűsból leszármaztatható csőpőrt, X jelentése egyszeres kémiaikötés, adőtt esetben egy vagy két őxigénatőmmal helyettesített kénatőmvagy adőtt esetben helyettesített nitrőgénatőm, A jelentése adőttesetben halőgénatőmmal, hidrőxilcsőpőrttal, adőtt esetbenfenilcsőpőrtőt viselő, 1-4 szénatőmős alkőxicsőpőrttal, 1-4 szénatőmősalkanőilőxicsőpőrttal, adőtt esetben helyettesített aminőcsőpőrttalés/vagy őxőcsőpőrttal helyettesített, egyenes vagy elágazó szénláncú,1-8 szénatőmős alkiléncsőpőrt, és n jelentése 1 vagy 2, azzal amegkötéssel, hőgy ha R1 jelentése (a) általánős képletű csőpőrt, ahőlAr jelentése fenilcsőpőrt, és R4 és R5 közül legalább az egyiknek ajelentése halőgénatőm, hidrőxilcsőpőrt, 1-3 szénatőmős alkilcsőpőrt,1-3 szénatőmős alkőxicsőpőrt, 1-4 szénatőmős alkanőilőxicsőpőrt vagymetán-szűlfőnilőxi-csőpőrt, akkőr A jelentése csak 1-4 szénatőmős,helyettesítetlen alkiléncsőpőrttól eltérő lehet, tővábbá azzal amegkötéssel, hőgy ha R1 jelentése 2,5-dihidrőxi-benzőilcsőpőrt, akkőrA jelentése csak őxőcsőpőrttal helyettesített alkiléncsőpőrttól eltérőlehet. A találmány szerinti (I) általánős képletű vegyületekhatékőnyan gátőlják a lipidek perőxidációját. ŕThe subject of the invention is the new compounds of the general formula (I), their pure stereoisomers, mixtures of stereoisomers, their salts, as well as the pharmaceutical preparations containing them, where R1 in the general formula (I) is a tube powder of the general formula (a), where Ar is 6 - 10 carbon atomized thermocycling tube powders, R4 and R5 are independently hydrogen atom, halogen atom, hydroxyl tube powder, 1-4 carbon atomized alkyl tube powders, optionally substituted with phenyl tube powder, 1-4 carbon atom aldehyde tube powders, 1-4 carbon atom alkyl-thio-tube powders, 1-4 carbon atoms radical alkylsulfinyl - pipe dust, 1-4 carbon atomized alkyl-sulfonyl pipe dust, nitro pipe dust, 1-4 carbon atomized alkanoyl pipe dust, optionally substituted amino pipe dust, carboxyl pipe powder, 1-4 carbon atom alkyloxy-carbonyl pipe powder, carboxyamide pipe powder, cyanide pipe powder, pipe powder and/or szúlfönamytsópőr, and p, q and r is independently 0 or 1, R2 and R3 are independently amino-tube powder or a 5-8-membered tube powder that can be derived from a saturated power cycle containing at least one nitrogen atom, X is a single chemical bond, optionally a sulfur atom substituted with one or two oxygen atoms or a nitrogen atom substituted where appropriate, A in the donor body with a halogen atom, a hydroxyl atom, if applicable a phenyl atom, with a 1-4 carbon atom, an 1-4 carbon atom, a 1-4 alkanoyl atom, where appropriate a substituted amino atom atom/or an alkylene atom with a straight or branched carbon chain, 1-8 carbon atoms, and n means 1 or 2, with the proviso that if R1 is a pipe powder of the general formula (a), where Ar is phenyl pipe powder, and at least one of R4 and R5 is a halogen atom, hydroxyl pipe powder, alkyl pipe powder with 1-3 carbon atoms, alkyl pipe powder with 1-3 carbon atoms, alkanoloxy pipe powder with 1-4 carbon atoms or methane-vinylphenyloxy- pipe powder , the meaning of battery A can only be different from 1-4 carbon atoms, unsubstituted alkylene tube powder, further with the proviso that if R1 is 2,5-dihydroxybenzyl tube powder, the meaning of battery A can only be different from alkylene tube powder substituted with x-tube carbon. The compounds of general formula (I) according to the invention effectively inhibit the peroxidation of lipids. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503012A HUT76265A (en) | 1995-10-19 | 1995-10-19 | Pyrimidine derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| PCT/HU1996/000058 WO1997014685A1 (en) | 1995-10-19 | 1996-10-14 | Pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9900088A2 true HUP9900088A2 (en) | 2000-03-28 |
Family
ID=10987303
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9503012A HUT76265A (en) | 1995-10-19 | 1995-10-19 | Pyrimidine derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| HU9900088A HUP9900088A2 (en) | 1995-10-19 | 1996-10-14 | Pyrimidine derivatives, pharmaceutical compositions containing them and process for producing them |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9503012A HUT76265A (en) | 1995-10-19 | 1995-10-19 | Pyrimidine derivatives, pharmaceutical compositions containing them, process for producing them and their use |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU7325996A (en) |
| HU (2) | HUT76265A (en) |
| WO (1) | WO1997014685A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI506561B (en) * | 2008-11-19 | 2015-11-01 | Internat Frontier Tech Lab Inc | Embossed hologram chip and its manufacturing method |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT958280E (en) | 1997-10-31 | 2005-09-30 | Daiichi Suntory Pharma Co Ltd | ARILPIPERIDINOPROPANOL AND ARILPIPERAZINOPROPANOL DERIVATIVES AND DRUGS CONTAINING THE SAME |
| AU2002217999A1 (en) | 2000-11-01 | 2002-05-15 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
| AU2003291141A1 (en) * | 2002-12-03 | 2004-06-23 | Epcellon, Inc. | 5-nitroso-6-piperazinyl-pyrimidine derivatives for treating ischemia |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| WO2006113679A2 (en) | 2005-04-15 | 2006-10-26 | Board Of Regents, The University Of Texas System | Delivery of sirna by neutral lipid compositions |
| WO2008016165A2 (en) * | 2006-07-31 | 2008-02-07 | Asubio Pharma Co., Ltd. | Liquid preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU214331B (en) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Methods for producing piperazine and homopiperazine derivatives and pharmaceutical compositions containing them |
| HU211995B (en) * | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
-
1995
- 1995-10-19 HU HU9503012A patent/HUT76265A/en unknown
-
1996
- 1996-10-14 WO PCT/HU1996/000058 patent/WO1997014685A1/en active Application Filing
- 1996-10-14 AU AU73259/96A patent/AU7325996A/en not_active Abandoned
- 1996-10-14 HU HU9900088A patent/HUP9900088A2/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI506561B (en) * | 2008-11-19 | 2015-11-01 | Internat Frontier Tech Lab Inc | Embossed hologram chip and its manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997014685A1 (en) | 1997-04-24 |
| HU9503012D0 (en) | 1995-12-28 |
| HUT76265A (en) | 1997-07-28 |
| AU7325996A (en) | 1997-05-07 |
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