HUP9801919A2 - Szénhidrátokhoz kötött bioaktív vegyületek - Google Patents

Szénhidrátokhoz kötött bioaktív vegyületek

Info

Publication number
HUP9801919A2
HUP9801919A2 HU9801919A HUP9801919A HUP9801919A2 HU P9801919 A2 HUP9801919 A2 HU P9801919A2 HU 9801919 A HU9801919 A HU 9801919A HU P9801919 A HUP9801919 A HU P9801919A HU P9801919 A2 HUP9801919 A2 HU P9801919A2
Authority
HU
Hungary
Prior art keywords
link
active compounds
bam
stands
carbohydrate conjugated
Prior art date
Application number
HU9801919A
Other languages
English (en)
Inventor
Esmir Gunic
Dusan Miljkovic
Zbigniew Pietrzkowski
Wilfried Seifert
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of HUP9801919A2 publication Critical patent/HUP9801919A2/hu
Publication of HUP9801919A3 publication Critical patent/HUP9801919A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Silicon Polymers (AREA)

Abstract

A találmány szerinti vegyületek MS-LINK-BAM általánős képletében MSjelentése mőnőszacharid, LINK jelentése linker, BAM jelentése biőaktívanyag, ahől MS kővalens kötéssel, de az MS C1 helyzetű szénatőmtóleltérő szénatőmőn keresztül kapcsőlódik LINK-hez, és LINK kővalenskötéssel kapcsőlódik BAM-hőz. A találmány kiterjed a fenti vegyületekelőállítására és alkalmazására. ŕ
HU9801919A 1995-12-21 1996-12-12 Carbohydrate conjugated bio-active compounds HUP9801919A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/576,817 US5723589A (en) 1995-12-21 1995-12-21 Carbohydrate conjugated bio-active compounds

Publications (2)

Publication Number Publication Date
HUP9801919A2 true HUP9801919A2 (hu) 1998-12-28
HUP9801919A3 HUP9801919A3 (en) 1999-11-29

Family

ID=24306125

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801919A HUP9801919A3 (en) 1995-12-21 1996-12-12 Carbohydrate conjugated bio-active compounds

Country Status (15)

Country Link
US (1) US5723589A (hu)
EP (1) EP0811011B1 (hu)
JP (1) JP3516959B2 (hu)
KR (1) KR19980702383A (hu)
CN (1) CN1182430A (hu)
AT (1) ATE245656T1 (hu)
AU (1) AU705363B2 (hu)
CA (1) CA2213489A1 (hu)
CZ (1) CZ264497A3 (hu)
DE (1) DE69629177T2 (hu)
HU (1) HUP9801919A3 (hu)
PL (1) PL321901A1 (hu)
RU (1) RU2141963C1 (hu)
SK (1) SK113797A3 (hu)
WO (1) WO1997023494A1 (hu)

Families Citing this family (36)

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WO1998036777A1 (en) * 1997-02-20 1998-08-27 Dime David S Site-specific drug delivery
US7033765B1 (en) 1997-02-20 2006-04-25 Toronto Research Chemicals, Inc. Site-specific drug delivery
CA2301725C (en) * 1997-08-28 2008-11-18 University Of Washington Specific saccharide compositions and methods for treating alzheimer's disease and other amyloidoses
JP2001526234A (ja) * 1997-12-22 2001-12-18 シェーリング コーポレイション 経口投与が可能な固形リバビリン投薬の形態およびそれらの製造プロセス
US6767898B2 (en) * 1998-08-28 2004-07-27 University Of Washington Methods for using specific saccharides for treating alzheimer's disease and other amyloidoses
DE19916108C1 (de) * 1999-04-09 2001-01-11 Aventis Pharma Gmbh Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
RU2197499C2 (ru) * 2001-08-23 2003-01-27 Бокованов Владимир Евгеньевич Металлоценовые производные сахаров и содержащее их средство для активации киллинга микроорганизмов, локализованных внутриклеточно
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
KR101174510B1 (ko) * 2002-09-11 2012-08-16 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬전분화 폴리펩티드, 특히 하이드록시알킬전분화 에리트로포이에틴
DE60323756D1 (de) * 2002-10-08 2008-11-06 Fresenius Kabi De Gmbh Pharmazeutisch aktive oligosaccharid-conjugate
EP1462116A1 (en) * 2003-03-29 2004-09-29 Villitech SARL Composition for treating the gastrointestinal tract
WO2005014024A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of a polymer and a protein linked by an oxime linking group
SG145746A1 (en) * 2003-08-08 2008-09-29 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and g-csf
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
EP1689439A2 (en) * 2003-09-22 2006-08-16 Acidophil LLC Small molecule compositions and methods for increasing drug efficiency using compositions thereof
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
EP2336192A1 (en) * 2004-03-11 2011-06-22 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
AU2006222187A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
GB0614034D0 (en) * 2006-07-14 2006-08-23 Iqur Ltd Antiviral compounds
EP2070951A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Method for producing a hydroxyalkyl starch derivatives with two linkers
EP2070950A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
ES2791683T3 (es) 2009-01-28 2020-11-05 Smartcells Inc Sistemas a base de conjugados para la administración controlada de fármacos
CA2750252A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
JP2012516339A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 外因的刺激型制御放出物質体およびその使用
KR20110110253A (ko) 2009-01-28 2011-10-06 스마트쎌스, 인크. 결정질 인슐린-접합체
EP2408808A4 (en) 2009-03-20 2015-05-06 Smartcells Inc TERMINAL-FUNCTIONALIZED CONJUGATES AND THEIR USE
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
EP2598527A4 (en) 2010-07-28 2014-01-08 Smartcells Inc RECOMBINANT EXPRESSED INSULIN POLYPEPTIDES AND APPLICATIONS THEREOF
CA2805902A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
CA2924743A1 (en) 2013-10-04 2015-04-09 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
RU2575925C1 (ru) * 2014-11-06 2016-02-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Тетравалентные неогликоконъюгаты с углеводным разветвляющим ядром и способ их получения

Family Cites Families (3)

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US3965262A (en) * 1973-03-01 1976-06-22 Strategic Medical Research Corporation Method of enhancing learning and/or memory in warm blooded animals
US4016261A (en) * 1973-03-01 1977-04-05 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US5154951A (en) * 1990-03-26 1992-10-13 Eastman Kodak Company Method and apparatus for use in bead coating a web with liquid composition

Also Published As

Publication number Publication date
EP0811011B1 (en) 2003-07-23
KR19980702383A (ko) 1998-07-15
EP0811011A4 (en) 1998-11-04
AU1417697A (en) 1997-07-17
CZ264497A3 (en) 1997-12-17
US5723589A (en) 1998-03-03
JP3516959B2 (ja) 2004-04-05
DE69629177T2 (de) 2004-04-15
EP0811011A1 (en) 1997-12-10
CN1182430A (zh) 1998-05-20
AU705363B2 (en) 1999-05-20
JPH10506413A (ja) 1998-06-23
HUP9801919A3 (en) 1999-11-29
PL321901A1 (en) 1998-01-05
DE69629177D1 (de) 2003-08-28
ATE245656T1 (de) 2003-08-15
RU2141963C1 (ru) 1999-11-27
WO1997023494A1 (en) 1997-07-03
SK113797A3 (en) 1998-02-04
CA2213489A1 (en) 1997-07-03

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