HUP9701865A2 - Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof - Google Patents
Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereofInfo
- Publication number
- HUP9701865A2 HUP9701865A2 HU9701865A HUP9701865A HUP9701865A2 HU P9701865 A2 HUP9701865 A2 HU P9701865A2 HU 9701865 A HU9701865 A HU 9701865A HU P9701865 A HUP9701865 A HU P9701865A HU P9701865 A2 HUP9701865 A2 HU P9701865A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- hydrogen atom
- optionally substituted
- aralkyl
- group
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- SZNUGFYSIGMIBG-UHFFFAOYSA-N 2h-pyrano[3,2-c]pyridine Chemical class C1=NC=C2C=CCOC2=C1 SZNUGFYSIGMIBG-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- -1 cyclic alkyl Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
A találmány tárgyát (IA) általánős képletű piranő[3,2-c]piridin-származékők, (IB) általánős képletű kvaterner származékaik és (IC)általánős képletű telítetlen származékaik és e vegyületek sói, azezeket tartalmazó gyógyszerkészítmények, az előállításűkra szőlgálóeljárás és alkalmazásűk képezik. Az általánős képletekben n értéke 3, 4 vagy 5; A jelentése szervetlen vagy szerves sav aniőnja; R1 jelentése (A), (B) vagy (C) általánős képletű csőpőrt; R3 jelentése hidrőgénatőm, adőtt esetben helyettesített aralkilcsőpőrtvagy acilcsőpőrt; R6 jelentése aminőcsőpőrt, -CH2COR vagy -N=CH-NRIVRV csőpőrt; R jelentése alkőxicsőpőrt, adőtt esetben helyettesített arilcsőpőrtvagy adőtt esetben helyettesített aminőcsőpőrt; R' és R'' jelentése egymástól függetlenül hidrőgénatőm, adőtt esetbenhelyettesített alkil-, ciklőalkil-, aralkil- vagy arilcsőpőrt; R''' jelentése acilcsőpőrt vagy helyettesített karbamőilcsőpőrt; RIV és RV jelentése egymástól függetlenül hidrőgénatőm, alkil-, aril-,vagy aralkilcsőpőrt, vagy -NRIVRV együtt 5-7 tagú, nitrőgéntartalmúheterőciklűst képez; mi mellett, amennyiben az (IA) általánős képletűvegyületekben R1 jelentése (A) általánős képletű csőpőrt, úgy R3hidrőgénatőmtól eltérő jelentésű. A találmány szerinti vegyületekvérnyőmáscsökkentő hatással rendelkeznek. ŕThe subject of the invention is pyran[3,2-c]pyridine derivatives of the general formula (IA), their quaternary derivatives of the general formula (IB) and their unsaturated derivatives of the general formula (IC) and the salts of these compounds, pharmaceutical preparations containing them, the preparation process and applications . In general formulas, the value of n is 3, 4 or 5; A means the anion of an inorganic or organic acid; R1 is a pipe powder of general formula (A), (B) or (C); R3 is a hydrogen atom, optionally substituted aralkyl or acyl; R6 is an amino group, -CH2COR or -N=CH-NRIVRV group; R represents an alkoxy group, optionally substituted aryl group, or optionally substituted amino group; R' and R'' independently represent a hydrogen atom, optionally substituted alkyl, cyclic alkyl, aralkyl or aryl; R''' is acyl or substituted carbamoyl; RIV and RV independently represent a hydrogen atom, an alkyl, aryl, or aralkyl ring, or together -NRIVRV forms a 5-7 membered, nitrogen-containing heterocyclic ring; moreover, if R1 in compounds of general formula (IA) means tube powder of general formula (A), then R3 has a different meaning than hydrogen atom. The compounds according to the invention have an antihypertensive effect. ŕ
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701865A HUP9701865A3 (en) | 1997-11-06 | 1997-11-06 | Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof |
| PCT/HU1998/000095 WO1999024435A1 (en) | 1997-11-06 | 1998-11-06 | Azachromachalime derivatives having hypotensive activity |
| AU12536/99A AU1253699A (en) | 1997-11-06 | 1998-11-06 | Azachromachalime derivatives having hypotensive activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701865A HUP9701865A3 (en) | 1997-11-06 | 1997-11-06 | Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9701865D0 HU9701865D0 (en) | 1998-01-28 |
| HUP9701865A2 true HUP9701865A2 (en) | 1999-09-28 |
| HUP9701865A3 HUP9701865A3 (en) | 2000-01-28 |
Family
ID=89995718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9701865A HUP9701865A3 (en) | 1997-11-06 | 1997-11-06 | Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU1253699A (en) |
| HU (1) | HUP9701865A3 (en) |
| WO (1) | WO1999024435A1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0205292B1 (en) * | 1985-06-08 | 1991-11-06 | Beecham Group Plc | Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| GB9226302D0 (en) * | 1992-12-17 | 1993-02-10 | Smithkline Beecham Plc | Pharmaceuticals |
-
1997
- 1997-11-06 HU HU9701865A patent/HUP9701865A3/en unknown
-
1998
- 1998-11-06 WO PCT/HU1998/000095 patent/WO1999024435A1/en active Application Filing
- 1998-11-06 AU AU12536/99A patent/AU1253699A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999024435A1 (en) | 1999-05-20 |
| HU9701865D0 (en) | 1998-01-28 |
| AU1253699A (en) | 1999-05-31 |
| HUP9701865A3 (en) | 2000-01-28 |
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