HUP9600476A2 - Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them - Google Patents

Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them

Info

Publication number
HUP9600476A2
HUP9600476A2 HU9600476A HUP9600476A HUP9600476A2 HU P9600476 A2 HUP9600476 A2 HU P9600476A2 HU 9600476 A HU9600476 A HU 9600476A HU P9600476 A HUP9600476 A HU P9600476A HU P9600476 A2 HUP9600476 A2 HU P9600476A2
Authority
HU
Hungary
Prior art keywords
carbon
atom
alkyl
pyrrolidinyl
general formula
Prior art date
Application number
HU9600476A
Other languages
Hungarian (hu)
Inventor
Alan David Palkowitz
Kenneth Jeff Thrasher
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/396,401 external-priority patent/US5510357A/en
Priority claimed from US08/552,679 external-priority patent/US5856339A/en
Priority claimed from US08/554,223 external-priority patent/US5856340A/en
Priority claimed from US08/552,564 external-priority patent/US5998441A/en
Priority claimed from US08/552,890 external-priority patent/US5919800A/en
Priority claimed from US08/552,565 external-priority patent/US5977093A/en
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HU9600476D0 publication Critical patent/HU9600476D0/en
Publication of HUP9600476A2 publication Critical patent/HUP9600476A2/en
Publication of HUP9600476A3 publication Critical patent/HUP9600476A3/en
Publication of HU226326B1 publication Critical patent/HU226326B1/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyület vagy gyógyászatiszempőntból alkalmas sója, ahől az (I) általánős képletben R1jelentése hidrőgénatőm, hidrőxilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt,-OCOC6H5, -OCO-(1-6 szénatőmős alkil) vagy -OSO2-(2-6 szénatőmősalkil) képletű csőpőrt; R2 jelentése hidrőgénatőm, hidrőxilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt, -OCOC6H5, -OCO-(1-6 szénatőmős alkil), -OSO2-(2-6 szénatőmős -alkil) képletű csőpőrt vagy halőgénatőm; R3jelentése 1-piperidinil-, 1-pirrőlidinil-, metil-1-pirőlidinil,dimetil-1-pirrőlidinil-, 4-mőrfőlinő-, dimetil-aminő-, dietil-aminő-,diizőprőpil-aminő- vagy 1-hexametilén-iminő-csőpőrt; n jelentése 2vagy 3; és Z jelentése őxigén- vagy kénatőm. Az (I) általánős képletűvegyületek alkalmasak a pősztmenőpaűzás szindrómaként összefőglaltbetegségek kezelésére. A találmány tárgyát képezik a vegyületekelőállítása sőrán felhasznált új intermedierek is. ŕThe subject of the invention is the compound of the general formula (I) or its salt suitable from a medical point of view, where R1 in the general formula (I) is a hydrogen atom, a hydroxyl group, a 1-4 carbon-alkoxy group, -OCOC6H5, -OCO-(1-6 carbon-alkyl) or -OSO2- pipe powder of the formula (C2-C6 alkyl); R2 represents a hydrogen atom, a hydroxyl atom, an 1-4 carbon-alkoxy atom, -OCOC6H5, -OCO-(1-6 carbon-alkyl), -OSO2-(2-6 carbon-alkyl) or a halo atom; R3 is 1-piperidinyl-, 1-pyrrolidinyl-, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl-, 4-methylamino-, dimethylamino-, diethylamino-, diisopropylamino- or 1-hexamethyleneimino- group; n is 2 or 3; and Z is an oxygen or sulfur atom. The compounds of the general formula (I) are suitable for the treatment of diseases classified as post-starvation syndrome. The subject of the invention is also the new intermediates often used in the production of compounds. ŕ

HU9600476A 1995-02-28 1996-02-27 Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them HU226326B1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/396,401 US5510357A (en) 1995-02-28 1995-02-28 Benzothiophene compounds as anti-estrogenic agents
US55276095A 1995-11-03 1995-11-03
US08/552,679 US5856339A (en) 1995-02-28 1995-11-03 Benzothiophene compounds, intermediates, compositions, and methods
US08/554,223 US5856340A (en) 1995-02-28 1995-11-03 Method of treating estrogen dependent cancers
US08/552,564 US5998441A (en) 1995-02-28 1995-11-03 Benzothiophene compounds, intermediates, compositions, and methods
US08/552,890 US5919800A (en) 1995-02-28 1995-11-03 Benzothiophene compounds, intermediates, compositions, and methods
US08/552,636 US5723474A (en) 1995-02-28 1995-11-03 Benzothiophene compounds, intermediates, compositions, and methods
US08/552,565 US5977093A (en) 1995-02-28 1995-11-03 Benzothiophene compounds, intermediates, compositions, and methods

Publications (4)

Publication Number Publication Date
HU9600476D0 HU9600476D0 (en) 1996-04-29
HUP9600476A2 true HUP9600476A2 (en) 1999-06-28
HUP9600476A3 HUP9600476A3 (en) 1999-07-28
HU226326B1 HU226326B1 (en) 2008-08-28

Family

ID=27575428

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9600476A HU226326B1 (en) 1995-02-28 1996-02-27 Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them

Country Status (8)

Country Link
CN (1) CN1086700C (en)
BR (1) BR9600829A (en)
CA (1) CA2170479C (en)
CZ (1) CZ290200B6 (en)
FI (1) FI120345B (en)
HU (1) HU226326B1 (en)
NO (1) NO314229B1 (en)
TR (1) TR199600127A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE535691C2 (en) * 2011-03-08 2012-11-13 Kat2Biz Ab Reduction of C-O bonds via catalytic transfer hydrogenolysis
CN102746290B (en) * 2012-06-21 2014-08-27 成都苑东药业有限公司 Thiazole compound and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (en) * 1991-05-25 1992-11-26 Schering Ag 2-PHENYLBENZO (B) FURANES AND THIOPHENES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Also Published As

Publication number Publication date
AU4579796A (en) 1996-09-05
FI960909A (en) 1996-08-29
NO960796D0 (en) 1996-02-27
FI120345B (en) 2009-09-30
CA2170479A1 (en) 1996-08-29
HU9600476D0 (en) 1996-04-29
AU699753B2 (en) 1998-12-17
FI960909A0 (en) 1996-02-27
CZ290200B6 (en) 2002-06-12
CN1086700C (en) 2002-06-26
CN1159448A (en) 1997-09-17
NO314229B1 (en) 2003-02-17
HUP9600476A3 (en) 1999-07-28
TR199600127A2 (en) 1996-10-21
CA2170479C (en) 2009-04-14
CZ58896A3 (en) 1996-09-11
BR9600829A (en) 1997-12-30
NO960796L (en) 1996-08-29
HU226326B1 (en) 2008-08-28

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees