HUP1600582A2 - 2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents - Google Patents

2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents

Info

Publication number
HUP1600582A2
HUP1600582A2 HU1600582A HUP1600582A HUP1600582A2 HU P1600582 A2 HUP1600582 A2 HU P1600582A2 HU 1600582 A HU1600582 A HU 1600582A HU P1600582 A HUP1600582 A HU P1600582A HU P1600582 A2 HUP1600582 A2 HU P1600582A2
Authority
HU
Hungary
Prior art keywords
pyridinophane
diaza
ligands
derivatives
metal ion
Prior art date
Application number
HU1600582A
Other languages
Hungarian (hu)
Inventor
Richard Botar
Zoltan Garda
Tamas Fodor
Kalman Ferenc Krisztian Dr
Viktoria Nagy
Tircso Gyula Dr
Toth Imre Dr
Original Assignee
Debreceni Egyetem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debreceni Egyetem filed Critical Debreceni Egyetem
Priority to HU1600582A priority Critical patent/HUP1600582A2/en
Priority to PCT/HU2016/000074 priority patent/WO2017089848A1/en
Priority to US15/778,489 priority patent/US10968224B2/en
Priority to EP16819646.7A priority patent/EP3380473A1/en
Publication of HUP1600582A2 publication Critical patent/HUP1600582A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
HU1600582A 2015-11-26 2016-10-18 2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents HUP1600582A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HU1600582A HUP1600582A2 (en) 2016-10-18 2016-10-18 2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents
PCT/HU2016/000074 WO2017089848A1 (en) 2015-11-26 2016-11-25 New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents
US15/778,489 US10968224B2 (en) 2015-11-26 2016-11-25 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
EP16819646.7A EP3380473A1 (en) 2015-11-26 2016-11-25 New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1600582A HUP1600582A2 (en) 2016-10-18 2016-10-18 2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents

Publications (1)

Publication Number Publication Date
HUP1600582A2 true HUP1600582A2 (en) 2018-05-02

Family

ID=89992279

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1600582A HUP1600582A2 (en) 2015-11-26 2016-10-18 2,11-diaza[3.3](2,6)-pyridinophane derivatives and their use as ligands in essential metal ion-based mri contrast agents

Country Status (1)

Country Link
HU (1) HUP1600582A2 (en)

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished