HUP1400378A2 - Process for the preparation of apixaban - Google Patents

Process for the preparation of apixaban

Info

Publication number
HUP1400378A2
HUP1400378A2 HU1400378A HUP1400378A HUP1400378A2 HU P1400378 A2 HUP1400378 A2 HU P1400378A2 HU 1400378 A HU1400378 A HU 1400378A HU P1400378 A HUP1400378 A HU P1400378A HU P1400378 A2 HUP1400378 A2 HU P1400378A2
Authority
HU
Hungary
Prior art keywords
apixaban
preparation
Prior art date
Application number
HU1400378A
Other languages
Hungarian (hu)
Inventor
Andras Mravik
Tamas Nagy
Janos Farago
Balazs Volk
Gyula Lukacs
Gabor Nemeth
Hatvari Ilona Czoborne
Peter Slegel
Gyoezoe Csonka-Kis
Robert Kormany
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HU1400378A priority Critical patent/HU231122B1/en
Priority to PCT/HU2015/050004 priority patent/WO2016020711A1/en
Publication of HUP1400378A2 publication Critical patent/HUP1400378A2/en
Publication of HU231122B1 publication Critical patent/HU231122B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
HU1400378A 2014-08-06 2014-08-06 Process for the preparation of apixaban HU231122B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU1400378A HU231122B1 (en) 2014-08-06 2014-08-06 Process for the preparation of apixaban
PCT/HU2015/050004 WO2016020711A1 (en) 2014-08-06 2015-08-03 Process for the preparation of apixaban

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1400378A HU231122B1 (en) 2014-08-06 2014-08-06 Process for the preparation of apixaban

Publications (2)

Publication Number Publication Date
HUP1400378A2 true HUP1400378A2 (en) 2016-02-29
HU231122B1 HU231122B1 (en) 2020-11-30

Family

ID=89991558

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1400378A HU231122B1 (en) 2014-08-06 2014-08-06 Process for the preparation of apixaban

Country Status (2)

Country Link
HU (1) HU231122B1 (en)
WO (1) WO2016020711A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2827459T3 (en) * 2016-04-04 2021-05-21 Zakl Farmaceutyczne Polpharma Sa Procedure for the preparation of apixaban
CN107434806A (en) * 2016-12-09 2017-12-05 陕西科技大学 γ crystal formation solid matters of a kind of Eliquis carboxylic acid derivates and preparation method thereof and purposes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744461A (en) 2001-09-21 2015-07-01 百时美施贵宝公司 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
TW200303201A (en) 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
US7396932B2 (en) 2004-09-28 2008-07-08 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
WO2012168364A1 (en) 2011-06-10 2012-12-13 Dipharma Francis S.R.L. Apixaban preparation process
EP2945946B1 (en) * 2013-01-17 2017-07-12 Glenmark Pharmaceuticals Limited Process for the preparation and purification of apixaban
CN103694237B (en) * 2014-01-07 2016-03-23 上海现代制药股份有限公司 A kind of preparation method of anticoagulant apixaban and key intermediate

Also Published As

Publication number Publication date
WO2016020711A1 (en) 2016-02-11
HU231122B1 (en) 2020-11-30

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