HUP1400025A1 - New dhydro-oxazinobenzodiazepine compounds a process for their preparation and pharmaceutical compositions containing them - Google Patents

New dhydro-oxazinobenzodiazepine compounds a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
HUP1400025A1
HUP1400025A1 HUP1400025A HUP1400025A1 HU P1400025 A1 HUP1400025 A1 HU P1400025A1 HU P1400025 A HUP1400025 A HU P1400025A HU P1400025 A1 HUP1400025 A1 HU P1400025A1
Authority
HU
Hungary
Prior art keywords
oxazinobenzodiazepine
dhydro
compounds
preparation
new
Prior art date
Application number
Other languages
English (en)
Original Assignee
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Priority to HU1400025A priority Critical patent/HU230684B1/hu
Priority to BR112016016892A priority patent/BR112016016892A2/pt
Priority to EA201691437A priority patent/EA030371B1/ru
Priority to JP2016547525A priority patent/JP2017503817A/ja
Priority to PCT/HU2015/000003 priority patent/WO2015110848A1/en
Priority to CN201580010667.2A priority patent/CN106211772A/zh
Priority to CA2937300A priority patent/CA2937300A1/en
Priority to US15/113,083 priority patent/US9926332B2/en
Priority to EP15709984.7A priority patent/EP3097110A1/en
Publication of HUP1400025A1 publication Critical patent/HUP1400025A1/hu
Publication of HU230684B1 publication Critical patent/HU230684B1/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU1400025A 2014-01-21 2014-01-21 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them HU230684B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HU1400025A HU230684B1 (en) 2014-01-21 2014-01-21 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
BR112016016892A BR112016016892A2 (pt) 2014-01-21 2015-01-20 Novos compostos de di-hidro-oxazinobenzodiazepina, um processo para sua preparação e composições farmacêuticas que os contêm
EA201691437A EA030371B1 (ru) 2014-01-21 2015-01-20 Дигидрооксазинобензодиазепиновые соединения, способ их получения и содержащие их фармацевтические композиции
JP2016547525A JP2017503817A (ja) 2014-01-21 2015-01-20 新しいジヒドロ−オキサジノベンゾジアゼピン化合物、その製法及び前記化合物を含有する医薬組成物
PCT/HU2015/000003 WO2015110848A1 (en) 2014-01-21 2015-01-20 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
CN201580010667.2A CN106211772A (zh) 2014-01-21 2015-01-20 新的二氢‑噁嗪并苯并二氮*化合物、它们的制备方法以及含有它们的药物组合物
CA2937300A CA2937300A1 (en) 2014-01-21 2015-01-20 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
US15/113,083 US9926332B2 (en) 2014-01-21 2015-01-20 Dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
EP15709984.7A EP3097110A1 (en) 2014-01-21 2015-01-20 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1400025A HU230684B1 (en) 2014-01-21 2014-01-21 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
HUP1400025A1 true HUP1400025A1 (en) 2015-07-28
HU230684B1 HU230684B1 (en) 2017-08-28

Family

ID=89991380

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1400025A HU230684B1 (en) 2014-01-21 2014-01-21 New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (9)

Country Link
US (1) US9926332B2 (hu)
EP (1) EP3097110A1 (hu)
JP (1) JP2017503817A (hu)
CN (1) CN106211772A (hu)
BR (1) BR112016016892A2 (hu)
CA (1) CA2937300A1 (hu)
EA (1) EA030371B1 (hu)
HU (1) HU230684B1 (hu)
WO (1) WO2015110848A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110811B (zh) * 2019-06-20 2024-08-13 北京万全德众医药生物技术有限公司 一种比拉斯汀中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419797D0 (en) 1984-08-03 1984-09-05 Beecham Group Plc Compounds
ATE255112T1 (de) * 1997-08-12 2003-12-15 Egyt Gyogyszervegyeszeti Gyar 1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmer
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
HU230760B1 (hu) * 2005-12-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Dihidro-2,3-benzodiazepin-származékok optikai izomerjei, eljárás ezek sztereoszelektív szintézisére, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és az eljárás közbenső termékei
FR2972454B1 (fr) 2011-03-08 2013-03-01 Servier Lab Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
US9926332B2 (en) 2018-03-27
WO2015110848A1 (en) 2015-07-30
US20170002020A1 (en) 2017-01-05
JP2017503817A (ja) 2017-02-02
HU230684B1 (en) 2017-08-28
EP3097110A1 (en) 2016-11-30
EA030371B1 (ru) 2018-07-31
BR112016016892A2 (pt) 2022-08-30
EA201691437A1 (ru) 2017-02-28
CA2937300A1 (en) 2015-07-30
CN106211772A (zh) 2016-12-07

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